AAA+ proteins: have engine, will work.

TitleAAA+ proteins: have engine, will work.
Publication TypeJournal Article
Year of Publication2005
JournalNature reviews. Molecular cell biology
Volume6
Issue7
Pagination519-29
Date Published2005 Jul
ISSN1471-0072
AbstractThe AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.
URLhttp://dx.doi.org/10.1038/nrm1684
DOI10.1038/nrm1684
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/16072036?dopt=Abstract
Short TitleNat Rev Mol Cell Biol