AAA+ proteins: have engine, will work.

TitleAAA+ proteins: have engine, will work.
Publication TypeJournal Article
Year of Publication2005
JournalNature reviews. Molecular cell biology
Date Published2005 Jul
AbstractThe AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.
PubMed Link
Short TitleNat Rev Mol Cell Biol