Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist.

TitleAttenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist.
Publication TypeJournal Article
Year of Publication2001
JournalJournal of neurosurgery
Volume95
Issue4
Pagination680-6
Date Published2001 Oct
ISSN0022-3085
AbstractAdenovirus-mediated overexpression of interleukin-1 receptor antagonist (IL-1ra) attenuates the inflammatory reaction and brain injury that follows focal cerebral ischemia. Recently, an inflammatory reaction after intracerebral hemorrhage (ICH) was identified. In this study the authors examine the hypothesis that overexpression of IL-1ra reduces brain injury (specifically edema formation) after ICH.
URLhttps://thejns.org/doi/10.3171/jns.2001.95.4.0680
DOI10.3171/jns.2001.95.4.0680
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/11596963?dopt=Abstract
Short TitleJ Neurosurg