Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.

TitleCompetition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.
Publication TypeJournal Article
Year of Publication2006
JournalBMC molecular biology
Volume7
Pagination1
Date Published2006 Jan 13
AbstractThe premature aging and cancer-prone Werner and Bloom syndromes are caused by defects in the RecQ helicase enzymes WRN and BLM, respectively. Recently, both WRN and BLM (as well as several other RecQ members) have been shown to possess a strand annealing activity in addition to the requisite DNA unwinding activity. Since an annealing function would appear to directly oppose the action of a helicase, we have examined in this study the dynamic equilibrium between unwinding and annealing mediated by either WRN or BLM.
URLhttps://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-2199-7-1
DOI10.1186/1471-2199-7-1
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/16412221?dopt=Abstract
Short TitleBMC Mol Biol