The effect of pregnancy on the metabolism of 14C phenytoin in the isolated perfused rat liver.

TitleThe effect of pregnancy on the metabolism of 14C phenytoin in the isolated perfused rat liver.
Publication TypeJournal Article
Year of Publication1978
JournalThe Journal of pharmacology and experimental therapeutics
Volume206
Issue2
Pagination439-47
Date Published1978 Aug
ISSN0022-3565
AbstractThe metabolism of [14C]phenytoin (DPH) was measured in isolated perfused livers from non-pregnant female rats and rats at 13, 15, 17, 19 and 21 days of gestation. The half-life of [14C]phenytoin in the perfusate was not significantly altered by pregnancy in livers perfused with 20% blood at 2 ml/min/g of liver but was increased from 38 min in control livers to 158 min in livers from rats at 21 days of gestation when livers were perfused with 10% blood at 1 ml/min/g of liver. Secretion of the glucuronide conjugate of 5-[14C]phenyl-5-parahydroxy-phenylhydantoin into the bile was markedly inhibited during the latter stages of pregnancy such that a 4-fold decrease in the cumulative secretion into the bile was present at 21 days of gestation. The bile/perfusate concentration ratio of the glucuronide after 30 min was 148 in control livers but decreased to 6 in livers from rats at 21 days gestation.
URLhttp://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=682124
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/682124?dopt=Abstract
Short TitleJ Pharmacol Exp Ther