The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model.

TitleThe endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model.
Publication TypeJournal Article
Year of Publication2010
JournalBMC medicine
Volume8
Pagination69
Date Published2010 Nov 3
AbstractCancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. A new splicing variant, endogenous soluble vascular endothelial growth factor receptor-2 (esVEGFR-2) that we recently identified is an endogenous selective inhibitor of lymphangiogenesis. To evaluate the antimetastatic potential of esVEGFR-2, gene therapy with vector expressing esVEGFR-2 (pesVEGFR-2) or endostatin (pEndo) as a positive control was conducted on murine metastatic mammary cancer.
URLhttps://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-8-69
DOI10.1186/1741-7015-8-69
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/21047425?dopt=Abstract
Short TitleBMC Med