The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy.

TitleThe Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy.
Publication TypeJournal Article
Year of Publication2018
JournalTrends in immunology
Volume39
Issue11
Pagination900-920
Date Published2018 Nov
ISSN1471-4906
AbstractThe human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome.
URLhttps://linkinghub.elsevier.com/retrieve/pii/S1471-4906(18)30172-8
DOI10.1016/j.it.2018.09.007
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/30392721?dopt=Abstract
Short TitleTrends Immunol