Improvement in Diagnosis of Histoplasma Meningitis by Combined Testing for Histoplasma Antigen and Immunoglobulin G and Immunoglobulin M Anti-Histoplasma Antibody in Cerebrospinal Fluid.

TitleImprovement in Diagnosis of Histoplasma Meningitis by Combined Testing for Histoplasma Antigen and Immunoglobulin G and Immunoglobulin M Anti-Histoplasma Antibody in Cerebrospinal Fluid.
Publication TypeJournal Article
Year of Publication2018
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume66
Issue1
Pagination89-94
Date Published2018 Jan 6
ISSN1058-4838
AbstractCentral nervous system (CNS) histoplasmosis is a life-threatening condition and represents a diagnostic and therapeutic challenge. Isolation of Histoplasma capsulatum from cerebrospinal fluid (CSF) or brain tissue is diagnostic; however, culture is insensitive and slow growth may result in significant treatment delay. We performed a retrospective multicenter study to evaluate the sensitivity and specificity of a new anti-Histoplasma antibody enzyme immunoassay (EIA) for the detection of IgG and IgM antibody in the CSF for diagnosis of CNS histoplasmosis, the primary objective of the study. The secondary objective was to determine the effect of improvements in the Histoplasma galactomannan antigen detection EIA on the diagnosis of Histoplasma meningitis.
URLhttps://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cix706
DOI10.1093/cid/cix706
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/29020213?dopt=Abstract
Short TitleClin Infect Dis