Intraparenchymal and intratumoral interstitial infusion of anti-glioma monoclonal antibody 8H9.

TitleIntraparenchymal and intratumoral interstitial infusion of anti-glioma monoclonal antibody 8H9.
Publication TypeJournal Article
Year of Publication2008
JournalNeurosurgery
Volume63
Issue6
Pagination1166-74; discussion 1174
Date Published2008 Dec
ISSN0148-396X
AbstractInterstitial infusion, a form of local delivery that bypasses the blood-brain barrier, has been shown to afford high regional concentrations of a therapeutic molecule while avoiding systemic exposure. The distribution of monoclonal antibodies administered via interstitial infusion has not been characterized, and this is salient in light of the potential sequestration by epitopes expressed by targeted tissue. Interstitial delivery of murine immunoglobulin G1 monoclonal antibody (MAb) 8H9 was investigated in a rodent model for the potential treatment of infiltrative gliomas.
URLhttps://academic.oup.com/neurosurgery/article-lookup/doi/10.1227/01.NEU.0000334052.60634.84
DOI10.1227/01.NEU.0000334052.60634.84
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/19057330?dopt=Abstract
Short TitleNeurosurgery