Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity.

TitleMechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity.
Publication TypeJournal Article
Year of Publication2001
JournalStroke
Volume32
Issue12
Pagination2932-8
Date Published2001 Dec 1
ISSN0039-2499
AbstractRed blood cell (RBC) lysis contributes to brain edema formation after intracerebral hemorrhage (ICH), and RBC hemolysate (oxyhemoglobin) has been implicated to be a spasminogen in subarachnoid hemorrhage. Whether cerebral ischemia contributes to brain edema formation after ICH remains unclear, however. The aims of this study were to test whether extravasation of RBCs induces cerebral ischemia and/or blood-brain barrier disruption in a rat ICH model characterized by perihematomal brain edema.
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/11739998?dopt=Abstract
Short TitleStroke