Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system.

TitleModeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system.
Publication TypeJournal Article
Year of Publication2018
JournalNeuro-oncology
Volume20
Issue9
Pagination1197-1206
Date Published2018 Aug 2
ISSN1522-8517
AbstractAmong diffusely infiltrative gliomas in adults, 20%-30% contain a point mutation in isocitrate dehydrogenase 1 (IDH1mut), which increases production of D-2-hydroxyglutarate (D2HG). This is so efficient that D2HG often reaches 30 mM within IDH1mut gliomas. Yet, while up to 100 ┬ÁM D2HG can be detected in the circulating cerebrospinal fluid of IDH1mut glioma patients, the exposure of nonneoplastic cells within and surrounding an IDH1mut glioma to D2HG is unknown and difficult to measure directly.
URLhttps://academic.oup.com/neuro-oncology/article-lookup/doi/10.1093/neuonc/noy051
DOI10.1093/neuonc/noy051
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/29660019?dopt=Abstract
Short TitleNeuro Oncol