Cervical Cancer is Preventable, but Still Leading Cancer in Kentucky

Posted: 1/10/2017 - Tags: Markey Cancer Center
At the beginning of the year, many women (and men) set resolutions around health and fitness, often focusing on weight loss. But one of the most important habits women can form revolves around regular health checks, particularly for preventable cancers. January is cervical cancer awareness month. Unfortunately, Kentucky ranks in the top 10 in the country for cervical cancer incidence and death rates – a dire statistic considering cervical cancer is largely preventable through vaccination and screening. The human papillomavirus (HPV) causes virtually all cases of cervical carcinomas. The majority of sexually active women will be exposed to HPV at some point in their... FULL STORY

New Study Shows Promise for Repurposing Anti-Malarial Drug for Cancer

Posted: 1/10/2017 - Tags: Markey Cancer Center, Research
A new study by University of Kentucky Markey Cancer Center researchers shows that chloroquine – a drug currently used to treat malaria – may be useful in treating patients with metastatic cancers. Published in Cell Reports, the study showed that chloroquine induced the secretion of the tumor suppressor protein Par-4 in both mouse models and in cancer patients in a clinical trial. Secreted Par-4 is essential for tumor cell death and the inhibition of tumor metastasis. Chloroquine induces Par-4 secretion via the classical secretory pathway that requires activation of p53 (a mutation of the p53 protein, or disturbances in the pathways that signal to p53, is common in... FULL STORY

Tindall-Staton Finds Passion in Research Close to Her Heart

Posted: 1/9/2017 - Tags: Research, Behavioral Science, Faculty
Michele Staton-Tindall grew up in rural Appalachia during a time when people felt so safe they didn’t even lock their doors at night. The ensuing drug epidemic that now ravages her former home has dramatically impacted the lives of the Appalachian people and broken that sense of security.Staton-Tindall, an associate professor in the  Department of Behavioral Science at the University of Kentucky's College of Medicine, and a faculty associate at the Center on Drug and Alcohol Research, has made it her mission to make a positive difference in the Appalachian area, particularly for women in the criminal justice population who have fallen prey to... FULL STORY

UK Multidisciplinary Team Presents First of its Kind Protocol for

Posted: 1/7/2017
Equestrian sports contributes to the highest percentage of traumatic brain injuries (TBI) in sports, based on findings in the National Trauma Databank. Multiple concussions and head trauma can have long-term consequences, including acute injuries and neurodegenerative diseases. Health providers, researchers and other professionals from the University of Kentucky who work in the area of traumatic brain injury developed and presented the Saddle Up Safely Concussion Assessment Tool and Return to Riding Protocol for Concussions in Equine Sports at the 5th International Consensus Conference on Concussion in Sports in Berlin, Germany, this past fall. The conference was... FULL STORY

Experimental Treatment for Parkinson's Symptoms Shows Early Promise

Posted: 1/6/2017 - Tags: Neurosurgery
 Laura Dawahare | UKnow | Jan. 6, 2017 "About 14 years ago, Bill Crawford noticed a persistent twitching in one of his fingers that was interfering with his rehearsal time as the music pastor at Porter Memorial Church. "It was driving me crazy," said the 57-year-old Lexingtonian.He'd noticed a few other things too, like weakness. He had mentioned it to his primary care physician, who ordered heart and lung function tests, but both were negative. Finally, however, he was so weak that he could no longer ride his bike. "I just couldn't seem to go," he said.  So he made an appointment with a neurologist.After a few minutes with Crawford, the... FULL STORY

Daugherty is Editor-in-Chief of American Heart Association Journal for

Posted: 1/4/2017 - Tags: Faculty, Research, Cardiovascular, Publications
Alan Daugherty, senior associate dean for research at the University of Kentucky College of Medicine, was recently approved to renew his contract as editor-in-chief of Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association (ATVB) for a second five-year term. ATVB is one of the five core journals of the American Heart Association. As editor of ATVB, Daugherty’s primary focus is on publishing the most important new research studies related to a spectrum of vascular diseases. “We’re also committed to presenting fair and balanced reviews of critical issues in the subject areas we cover,” he said. Daugherty also serves as director... FULL STORY

UK Researcher Traces Molecular Pathways to Obesity and Cardiovascular

Posted: 12/22/2016 - Tags: Pharmacology, Research, Pharmacology and Nutritional Sciences, BPA Exposure, CVD
An array of scientific evidence demonstrates a correlation between diets high in fat and cholesterol content and blockages in the arteries, which lead to cardiovascular disease (CVD). But a lesser-known risk factor for CVD is exposure to the chemical compound biphenyl A, or BPA, a base component of consumer plastic products such as water bottles. A fundamental and ubiquitous commodity in modern life, plastics are inexpensive to produce, with more than 300 million tons processed in 2010. The World Economic Forum warns the amount of plastic in the world’s oceans will exceed the amount of fish, in terms of weight, by 2050 at the current rate of production. As a base... FULL STORY

Treatment Took His Sense of Taste – But Life is Now Sweeter for Markey

Posted: 12/20/2016 - Tags: Markey Cancer Center
It wasn't until he could no longer open his mouth to take a bite of a cheeseburger that Winchester resident Barry Warner knew something was seriously wrong.In fall 2009, Warner had just returned from a golf trip where he'd begun experiencing some mildly annoying symptoms: a little discomfort while eating; a reduced appetite. But he pushed on, assuming the issue would clear up on its own."I have a high threshold for pain," Warner said. "I don't always go to the doctor for everything. I usually let it run its course."But once the pain escalated — leading to the aforementioned jaw mobility issue -- Warner sought the opinion of a friend with expertise in the area: the oral... FULL STORY

Al-Siraj’s Sex Chromosome Study Published in Circulation

Posted: 12/15/2016
Yasir Al-Siraj, a Ph.D. candidate in the University of Kentucky College of Medicine Department of Pharmacology and Nutritional Sciences, is the lead author of a paper published in Circulation, a leading journal on cardiovascular medicine. The article, “Female Mice with an XY Sex Chromosome Complement Develop Severe Angiotensin II-Induced Abdominal Aortic Aneurysms,” was co-authored by UK colleagues Sean E. Thatcher, Richard Charnigo, Kuey Chen, Eric Blalock, Alan Daugherty and Lisa Cassis.Al-Siraj said about Circulation, “It is very respected in the scientific community, and this journal has only an 8 percent acceptance rate, with a bias towards clinical studies. So... FULL STORY

What Does the 1812 Overture TASTE Like?

Posted: 12/14/2016
LEXINGTON, Ky. (Dec. 14, 2016) —"also.... just becauseI am working out the flavor for the 1812 OvertureI will most likely put it into a lolli this is an incredible challengeas it is making me cry while I listen…"Taria Camerino's poetic email sums up her passion for helping people explore how flavor perception is influenced by more than the tongue.  Her emotion is genuine: as a gastral synesthete, she experiences ALL senses as taste."I can't tell you what the color blue tastes like unless I'm looking at something blue," she explains.  But she has a distinct taste for every shade of blue: the oceans on a world map, for example, have a metallic... FULL STORY

Longtime UK Clinical Lab Employee Leaves Estate to Kentucky Children'

Posted: 12/13/2016
She was known for her kind disposition, being an avid Elvis fan and her trademark long black hair always pinned in bun on top of her head with a bow matching the outfit she was wearing that day. Maquies Bentley was a dedicated, loyal and exemplary employee at the University of Kentucky College of Medicine for 27 years. When she passed away in 2015, she continued to give back to UK by leaving her entire estate to the Kentucky Children’s Hospital. A former staff support associate in the Pathology/Clinical Lab department, Bentley is remembered by co-workers as being soft-spoken and well-liked by all who knew her. On Tuesday, the UK Board of Trustees is slated to... FULL STORY

Alzheimer's Association Awards $1 Million Grant to UK Sanders-Brown

Posted: 12/9/2016 - Tags: Alzheimer's research, Research
Linda Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, was awarded a "Part the Cloud" translational research grant from the Alzheimer's Association. This two-year, $997,738 grant will fund early clinical trials for a promising new treatment for Alzheimer's disease. Currently, Van Eldik’s team is exploring brain inflammation's role in nerve cell damage as a first step in identifying opportunities to suppress detrimental inflammatory molecules. "Brain inflammation is now recognized as an important driver of neurodegenerative disease progression and we desperately need new selective anti-inflammatory drugs to be tested in humans," said... FULL STORY