A novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to <i>Candida albicans</i> and <i>Staphylococcus aureus</i> biofilms.

TitleA novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms.
Publication TypeJournal Article
Year of Publication2016
JournalMetabolomics : Official journal of the Metabolomic Society
Volume12
Issue12
Pagination189
Date Published2016
ISSN1573-3882
AbstractCombined infections from Candida albicans and Staphylococcus aureus are a leading cause of death in the developed world. Evidence suggests that Candida enhances the virulence of Staphylococcus-hyphae penetrate through tissue barriers, while S. aureus tightly associates with the hyphae to obtain entry to the host organism. Indeed, in a biofilm state, C. albicans enhances the antimicrobial resistance characteristics of S. aureus. The association of these microorganisms is also associated with significantly increased morbidity and mortality. Due to this tight association we hypothesised that metabolic effects were also in evidence.
DOI10.1007/s11306-016-1134-2
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/28003796?dopt=Abstract
Short TitleMetabolomics