Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Patients.

TitlePersistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Patients.
Publication TypeJournal Article
Year of Publication2017
JournalJournal of the International Association of Providers of AIDS Care
Volume16
Issue5
Pagination512-515
Date Published2017 Sep/Oct
ISSN2325-9574
AbstractThe duration of macrocytosis after stopping zidovudine (ZDV) is unknown. Among 104 HIV-infected patients treated with ZDV for more than 1 year, 84 patients had macrocytosis at ZDV discontinuation. The median mean corpuscular volume (MCV) was 114.6 fL (range 100-128 fL). Patients were divided into 2 groups: those who did (resolved macrocytosis, n = 36) and did not (persistent macrocytosis, n = 48) normalize MCV at 3 to 6 months after ZDV discontinuation. Alcohol use ( P = .02), smoking ( P = .03), and lower (but within normal range) folic acid levels ( P = .05) were related to the persistence of macrocytosis. A persistence of macrocytosis was observed in 57% at 3 to 6 months, 38% at 1 year and 37% at 2 years after ZDV therapy had stopped. Duration of ZDV therapy did not have an effect on the persistence of macrocytosis ( P = .73). The median time for the MCV to normalize after stopping ZDV was 12.5 months.
URLhttp://journals.sagepub.com/doi/full/10.1177/2325957417702486?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI10.1177/2325957417702486
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/28393661?dopt=Abstract
Short TitleJ Int Assoc Provid AIDS Care