Posttranslational modification of mammalian AP endonuclease (APE1).

TitlePosttranslational modification of mammalian AP endonuclease (APE1).
Publication TypeJournal Article
Year of Publication2010
JournalCellular and molecular life sciences : CMLS
Volume67
Issue21
Pagination3609-20
Date Published2010 Nov
ISSN1420-682X
AbstractA key issue in studying mammalian DNA base excision repair is how its component proteins respond to a plethora of cell-signaling mediators invoked by DNA damage and stress-inducing agents such as reactive oxygen species, and how the actions of individual BER proteins are attributed to cell survival or apoptotic/necrotic death. This article reviews the past and recent progress on posttranslational modification (PTM) of mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1).
URLhttps://dx.doi.org/10.1007/s00018-010-0487-3
DOI10.1007/s00018-010-0487-3
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/20711647?dopt=Abstract
Short TitleCell Mol Life Sci