Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.

TitleProlyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.
Publication TypeJournal Article
Year of Publication2014
JournalBMC cancer
Volume14
Pagination1
Date Published2014 Jan 2
AbstractIncreased collagen deposition provides physical and biochemical signals to support tumor growth and invasion during breast cancer development. Therefore, inhibition of collagen synthesis and deposition has been considered a strategy to suppress breast cancer progression. Collagen prolyl-4-hydroxylase α subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition. However, expression and function of P4HA2 in breast cancer progression are not well investigated.
URLhttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-1
DOI10.1186/1471-2407-14-1
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/24383403?dopt=Abstract
Short TitleBMC Cancer