Prototype anionic detergent technique used to decellularize allograft valve conduits evaluated in the right ventricular outflow tract in sheep.

TitlePrototype anionic detergent technique used to decellularize allograft valve conduits evaluated in the right ventricular outflow tract in sheep.
Publication TypeJournal Article
Year of Publication2004
JournalThe Journal of heart valve disease
Volume13
Issue5
Pagination831-40
Date Published2004 Sep
ISSN0966-8519
AbstractBiodegradable polymeric materials or extracellular matrix scaffolds are used in tissue-engineered heart valve designs, with the expectation of replicating the anatomic, histological and biomechanical characteristics of semi-lunar valves. The study aim was to evaluate the extent of in-vivo recellularization and the explant pathology findings of a prototype anionic, non-denaturing detergent and endonuclease technique used to decellularize allograft (homograft) valve conduits implanted in the right ventricular outflow tract (RVOT) of sheep, and to identify possible risks associated with tissue-engineered heart valve conduits based on decellularized allograft semilunar valve scaffolds.
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/15473487?dopt=Abstract
Short TitleJ Heart Valve Dis