The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.

TitleThe renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
Publication TypeJournal Article
Year of Publication2014
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume20
Issue22
Pagination5848-5859
Date Published2014 Nov 15
ISSN1078-0432
AbstractWe previously showed that EGF receptor (EGFR) promotes tumorigenesis in the azoxymethane/dextran sulfate sodium (AOM/DSS) model, whereas vitamin D suppresses tumorigenesis. EGFR-vitamin D receptor (VDR) interactions, however, are incompletely understood. Vitamin D inhibits the renin-angiotensin system (RAS), whereas RAS can activate EGFR. We aimed to elucidate EGFR-VDR cross-talk in colorectal carcinogenesis.
URLhttp://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=25212605
DOI10.1158/1078-0432.CCR-14-0209
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/25212605?dopt=Abstract
Short TitleClin Cancer Res