The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity.

TitleThe role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity.
Publication TypeJournal Article
Year of Publication2015
JournalActa biomaterialia
Volume25
Pagination284-90
Date Published2015 Oct
ISSN1742-7061
AbstractMonosaccharide coated iron oxide nanoparticles were developed to selectively target colon cancer cell lines for magnetically mediated energy delivery therapy. The nanoparticles were prepared using a coupling reaction to attach the glucose functional group to the iron oxide core, and functionality was confirmed with physicochemical characterization techniques. The targeted nanoparticles were internalized into CT26 cells at a greater extent than non-targeted nanoparticles, and the nanoparticles were shown to be localized within lysosomes. Cells with internalized nanoparticles were exposed to an AMF to determine the potential to delivery therapy. Cellular ROS generation and apoptotic cell death was enhanced with field exposure. The nanoparticle coatings inhibit the Fenton-like surface generation of ROS suggesting a thermal or mechanical effect is more likely the source of the intracellular effect, unless the nanoparticle coating is unstable in the cellular environment.
URLhttps://linkinghub.elsevier.com/retrieve/pii/S1742-7061(15)30008-8
DOI10.1016/j.actbio.2015.06.037
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/26143604?dopt=Abstract
Short TitleActa Biomater