Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer.

TitleTargeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer.
Publication TypeJournal Article
Year of Publication2009
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume15
Issue23
Pagination7207-16
Date Published2009 Dec 1
ISSN1078-0432
AbstractThe mammalian target of rapamycin (mTOR) kinase acts downstream of phosphoinositide 3-kinase/Akt to regulate cellular growth, metabolism, and cytoskeleton. Because approximately 60% of sporadic colorectal cancers (CRC) exhibit high levels of activated Akt, we determined whether downstream mTOR signaling pathway components are overexpressed and activated in CRCs.
URLhttp://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19934294
DOI10.1158/1078-0432.CCR-09-1249
PubMed Linkhttp://www.ncbi.nlm.nih.gov/pubmed/19934294?dopt=Abstract
Short TitleClin Cancer Res