Craig G. van Horne

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craigvanhorne@uky.edu

859-323-1334

800 Rose St. MS 103B

Brain Restoration Center

Position(s):

Vice Chairman, Department of Neurosurgery

Professor of Neurosurgery

Co-Director, Brain Restoration Center

Virginia T. Barrow Endowed Chair

Affiliation(s):

Neurosurgery

Other Affiliation(s):

Neuroscience - Joint Faculty

Bio / Education:

Dr. van Horne is a Professor in the Department of Neurosurgery at the University of Kentucky. He graduated from the University of Colorado School of Medicine with an MD as well as a PhD in treatment strategies for Parkinson's disease. He completed his residency training in Neurosurgery at Brigham and Women's Hospital in Boston, Massachusetts. Dr. van Horne is Board Certified by the American Board of Neurological Surgery and is nationally and internationally recognized as an expert in Neurosurgery.

Dr. van Horne has extensive experience in the diagnosis and treatment of movement disorders. He specialized in Deep Brain Stimulation for Parkinson's disease and other movement disorders. His current research focuses on innovative and novel surgical treatment strategies for Parkinson's disease.

PubMed Publications:

Welleford, AS ; Quintero, JE ; Seblani, NE ; Blalock, E.; Gunewardena, S ; Shapiro, SM ; Riordan, SM ; Huettl, P.; Guduru, Z ; Stanford, JA ; van Horne, CG ; Gerhardt, GA "RNA Sequencing of Human Peripheral Nerve in Response to Injury: Distinctive Analysis of the Nerve Repair Pathways." Cell transplantation 29, (2020): 963689720926157. [PubMed Link] | [ Full text ]
Seblani, El ; Welleford, AS ; Quintero, JE ; van Horne, CG ; Gerhardt, GA "Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS." Journal of neuroscience methods 335, (2020): 108623. [PubMed Link] | [ Full text ]
Dillen, WL ; van Horne, CG ; Fraser, JF "Novel approach to the treatment of a cerebral abscess using the Apollo vibration/suction device." Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 55, (2018): 93-96. [PubMed Link] | [ Full text ]
van Horne, CG ; Quintero, JE ; Slevin, JT ; Anderson-Mooney, A.; Gurwell, JA ; Welleford, AS ; Lamm, JR ; Wagner, RP ; Gerhardt, GA "Peripheral nerve grafts implanted into the substantia nigra in patients with Parkinson's disease during deep brain stimulation surgery: 1-year follow-up study of safety, feasibility, and clinical outcome." Journal of neurosurgery 129, 6 (2018): 1550-1561. [PubMed Link] | [ Full text ]
Combs, HL ; Garcia-Willingham, NE ; Berry, DTR ; van Horne, CG ; Segerstrom, SC "Psychological functioning in Parkinson's disease post-deep brain stimulation: Self-regulation and executive functioning." Journal of psychosomatic research 111, (2018): 42-49. [PubMed Link] | [ Full text ]
van Horne, CG ; Quintero, JE ; Gurwell, JA ; Wagner, RP ; Slevin, JT ; Gerhardt, GA "Implantation of autologous peripheral nerve grafts into the substantia nigra of subjects with idiopathic Parkinson's disease treated with bilateral STN DBS: a report of safety and feasibility." Journal of neurosurgery 126, 4 (2017): 1140-1147. [PubMed Link] | [ Full text ]
Cunningham, MG ; Yadollahikhales, G ; Vitaliano, G ; Van Horne, C "Administration of electroconvulsive therapy for depression associated with deep brain stimulation in a patient with post-traumatic Parkinson's Disease: a case study." BMC psychiatry 16, 1 (2016): 399. [PubMed Link] | [ Full text ]
Deeb, W.; Giordano, JJ ; Rossi, PJ ; Mogilner, AY ; Gunduz, A.; Judy, JW ; Klassen, BT ; Butson, CR ; Van Horne, C ; Deny, D.; Dougherty, DD ; Rowell, D.; Gerhardt, GA ; Smith, GS ; Ponce, FA ; Walker, HC ; Bronte-Stewart, HM ; Mayberg, HS ; Chizeck, HJ ; Langevin, JP ; Volkmann, J.; Ostrem, JL ; Shute, JB ; Jimenez-Shahed, J.; Foote, KD ; Wagle Shukla, A.; Rossi, MA ; Oh, M.; Pourfar, M.; Rosenberg, PB ; Silburn, PA ; Hemptine, C.; Starr, PA ; Denison, T.; Akbar, U.; Grill, WM ; Okun, MS "Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies." Frontiers in integrative neuroscience 10, (2016): 38. [PubMed Link] | [ Full text ]
Rossi, PJ ; Gunduz, A.; Judy, J.; Wilson, L.; Machado, A.; Giordano, JJ ; Elias, WJ ; Rossi, MA ; Butson, CL ; Fox, MD ; McIntyre, CC ; Pouratian, N.; Swann, NC ; Hemptinne, C.; Gross, RE ; Chizeck, HJ ; Tagliati, M.; Lozano, AM ; Goodman, W.; Langevin, JP ; Alterman, RL ; Akbar, U.; Gerhardt, GA ; Grill, WM ; Hallett, M.; Herrington, T.; Herron, J.; Van Horne, C ; Kopell, BH ; Lang, AE ; Lungu, C.; Martinez-Ramirez, D.; Mogilner, AY ; Molina, R.; Opri, E.; Otto, KJ ; Oweiss, KG ; Pathak, Y.; Shukla, A.; Shute, J.; Sheth, SA ; Shih, LC ; Steinke, GK ; Trőster, AI ; Vanegas, N.; Zaghloul, KA ; Cendejas-Zaragoza, L.; Verhagen, L.; Foote, KD ; Okun, MS "Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies." Frontiers in neuroscience 10, (2016): 119. [PubMed Link] | [ Full text ]
van Horne, CG ; Vaughan, SW ; Massari, C.; Bennett, M.; Asfahani, WS ; Quintero, JE ; Gerhardt, GA "Streamlining deep brain stimulation surgery by reversing the staging order." Journal of neurosurgery 122, 5 (2015): 1042-7. [PubMed Link] | [ Full text ]
Combs, HL ; Folley, BS ; Berry, DT ; Segerstrom, SC ; Han, DY ; Anderson-Mooney, AJ ; Walls, BD ; Van Horne, C "Cognition and Depression Following Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus Pars Internus in Parkinson's Disease: A Meta-Analysis." Neuropsychology review 25, 4 (2015): 439-54. [PubMed Link] | [ Full text ]
Querfurth, HW ; Lieberman, P ; Arms, S ; Mundell, S ; Bennett, M.; Van Horne, C "Ophthalmodynamometry for ICP prediction and pilot test on Mt. Everest." BMC neurology 10, (2010): 106. [PubMed Link] | [ Full text ]
Santagata, S.; Van Horne, C ; Sallan, SE ; McLaughlin, ME ; Ramakrishna, NR "Post-irradiation meningioma with sarcoidosis." Journal of neuro-oncology 82, 3 (2007): 271-2. [PubMed Link] | [ Full text ]
Cicchetti, F ; Fodor, W ; Deacon, TW ; Van Horne, C ; Rollins, S ; Burton, W ; Costantini, LC ; Isacson, O "Immune parameters relevant to neural xenograft survival in the primate brain." Xenotransplantation 10, 1 (2003): 41-9. [PubMed Link] | [ Full text ]
Palmer, MR ; Granholm, AC ; van Horne, CG ; Giardina, KE ; Freund, RK ; Moorhead, JW ; Gerhardt, GA "Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats." Brain research 890, 1 (2001): 86-99. [PubMed Link] | [ Full text ]
Isacson, O ; Van Horne, C ; Schumacher, JM ; Brownell, AL "Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology." Advances in neurology 86, (2001): 447-54. [PubMed Link] |
Starr, PA ; Wichmann, T ; Van Horne, C ; Bakay, RA "Intranigral transplantation of fetal substantia nigra allograft in the hemiparkinsonian rhesus monkey." Cell transplantation 8, 1 (1999): 37-45. [PubMed Link] | [ Full text ]
Granholm, AC ; Henry, S.; Herbert, MA ; Eken, S.; Gerhardt, GA ; Van Horne, C "Kidney cografts enhance fiber outgrowth from ventral mesencephalic grafts to the 6-OHDA-lesioned striatum, and improve behavioral recovery." Cell transplantation 7, 2 (1998): 197-212. [PubMed Link] | [ Full text ]
Hoffman, AF ; van Horne, CG ; Eken, S.; Hoffer, BJ ; Gerhardt, GA "In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF." Experimental neurology 147, 1 (1997): 130-41. [PubMed Link] | [ Full text ]
Granholm, AC ; Mott, JL ; Bowenkamp, K.; Eken, S.; Henry, S.; Hoffer, BJ ; Lapchak, PA ; Palmer, MR ; Van Horne, C ; Gerhardt, GA "Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum." Experimental brain research 116, 1 (1997): 29-38. [PubMed Link] | [ Full text ]
Hebert, MA ; van Horne, CG ; Hoffer, BJ ; Gerhardt, GA "Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis." The Journal of pharmacology and experimental therapeutics 279, 3 (1996): 1181-90. [PubMed Link] | [ Full text ]
Hoffer, BJ ; Van Horne, C "Survival of dopaminergic neurons in fetal-tissue grafts." The New England journal of medicine 332, 17 (1995): 1163-4. [PubMed Link] | [ Full text ]
Hudson, JL ; van Horne, CG ; Strömberg, I.; Brock, S.; Clayton, J.; Masserano, J.; Hoffer, BJ ; Gerhardt, GA "Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats." Brain research 626, 1-2 (1993): 167-74. [PubMed Link] | [ Full text ]
Freund, RK ; van Horne, CG ; Harlan, T ; Palmer, MR "Electrophysiological interactions of ethanol with GABAergic mechanisms in the rat cerebellum in vivo." Alcoholism, clinical and experimental research 17, 2 (1993): 321-8. [PubMed Link] | [ Full text ]
Van Horne, C ; Hoffer, BJ ; Strömberg, I.; Gerhardt, GA "Clearance and diffusion of locally applied dopamine in normal and 6-hydroxydopamine-lesioned rat striatum." The Journal of pharmacology and experimental therapeutics 263, 3 (1992): 1285-92. [PubMed Link] | [ Full text ]
Strömberg, I.; Van Horne, C ; Bygdeman, M.; Weiner, N.; Gerhardt, GA "Function of intraventricular human mesencephalic xenografts in immunosuppressed rats: an electrophysiological and neurochemical analysis." Experimental neurology 112, 2 (1991): 140-52. [PubMed Link] | [ Full text ]
van Horne, CG ; Strömberg, I.; Young, D.; Olson, L.; Hoffer, B. "Functional enhancement of intrastriatal dopamine-containing grafts by the co-transplantation of sciatic nerve tissue in 6-hydroxydopamine-lesioned rats." Experimental neurology 113, 2 (1991): 143-54. [PubMed Link] | [ Full text ]
van Horne, CG ; Bement, S.; Hoffer, BJ ; Gerhardt, GA "Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS." Neuroscience letters 120, 2 (1990): 249-52. [PubMed Link] | [ Full text ]
van Horne, CG ; Mahalik, T ; Hoffer, B.; Bygdeman, M.; Almqvist, P ; Stieg, P ; Seiger, A.; Olson, L.; Strömberg, I. "Behavioral and electrophysiological correlates of human mesencephalic dopaminergic xenograft function in the rat striatum." Brain research bulletin 25, 2 (1990): 325-34. [PubMed Link] | [ Full text ]
Palmer, MR ; van Horne, CG ; Harlan, JT ; Moore, EA "Antagonism of ethanol effects on cerebellar Purkinje neurons by the benzodiazepine inverse agonists Ro 15-4513 and FG 7142: electrophysiological studies." The Journal of pharmacology and experimental therapeutics 247, 3 (1988): 1018-24. [PubMed Link] | [ Full text ]
Zottoli, SJ ; Van Horne, C "Posterior lateral line afferent and efferent pathways within the central nervous system of the goldfish with special reference to the Mauthner cell." The Journal of comparative neurology 219, 1 (1983): 100-11. [PubMed Link] | [ Full text ]