Guoying Bing | College of Medicine

Guoying Bing

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gbing@uky.edu

Position(s):

Professor

Regular Faculty

Affiliation(s):

Neuroscience

Research Description:

Neuroinflammation Mediated Dopaminergic Cell Death

Parkinson’s Disease (PD) is a neurodegenerative disease characterized by loss of the dopamine-containing neurons in the substantia nigra pars compacta (SNpc). Although the cause of neuronal death remains unclear, increasing evidence points to the role of chronic inflammatory processes. In order to explore the possibility that microglial activation causes dopaminergic cell death in the SNpc, lipopolysaccharide (LPS), a bacterial endotoxin that activate microglia, was into the substantia nigra (SN). The LPS injection not only caused the activation of microglia, but also resulted in a dose-dependent, selective loss of dopaminergic neurons by apoptosis in the SNpc. We therefore hypothesize that LPS activates microglia in the SN resulting in the release of cytotoxic agents. These agents, in turn, activate signal transduction pathways that cause neuronal degeneration of dopaminergic neurons in the SN. The long-term goal of this study is to validate LPS injection as a new animal model of PD that can be used to elucidate the etiology and molecular mechanisms underlying PD and to develop novel therapeutic treatments for this and other neurodegenerative diseases.

Influence of Xenobiotic Metabolites on the Neuronal Cell Death
Dr. Bing’s laboratory has recently found that a high level of microsomal epoxide hydrolase (mEH) expression in the brain of patients with Alzheimer’s disease as well as the rat brain following exposure to neurodegenerative agents such as kainic acid and trimethyl-tin. Relatively little is known about the expression and function of mEH in the CNS. However, the dual function of mEH in the activation as well as the inactivation of various reactive compounds from xenobiotic metabolites has important implications regarding its role in brain toxicity. The hypothesize is that mEH plays a crucial role in the biotransformation of endogenous xenobiotics and/or environmental chemicals into more toxic metabolites which may cause neuronal degeneration in specific neuronal populations. The identifying the exact role of mEH as well as the role of xenobiotic metabolites in the brain will be critical in understanding the neurodegeneration induced by exposure to toxic chemicals.

Selected Publications:

1. Choi DY, Zhang J, Bing G. Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats. Neurobiol Aging. 2010, 31(9):1649-53. PMID: 18986737

2. Xing B, Xin T, Zhao L, Hunter RL, Chen Y, Bing G. Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity. J Neuroimmunol. 2010, 25;225(1-2):43-51. PMCID: PMC2924924.PMID: 20471698

3. Liu M, Choi DY, Hunter RL, Pandya JD, Cass WA, Sullivan PG, Kim HC, Gash DM, Bing G. Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats. J Neurochem. 2010, 112(3):773-83. PMID: 19922440

4. Nguyen XV, Liu M, Kim HC, Bing G. Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP. Exp Neurol. 2009, 219(1):228-38. Epub 2009 Jun 3. PMID: 19500577

5. Hunter RL, Cheng B, Choi DY, Liu M, Liu S, Cass WA, Bing G. Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice. J Neurosci Res. 2009, 87(8):1913-21. PMCID: PMC2692550, PMID: 19224579

6. Choi DY, Liu M, Hunter RL, Cass WA, Pandya JD, Sullivan PG, Shin EJ, Kim HC, Gash DM, Bing G. Striatal neuroinflammation promotes Parkinsonism in rats. PLoS One. 2009, 4(5):e5482. Epub 2009 May 8. PMCID: PMC2674956, PMID: 19424495

7. Liu M, Hunter R, Nguyen XV, Kim HC, Bing G. Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment. J Neurosci Res. 2008, 86(12):2792-801. PMID: 18500758

8. Hunter RL, Liu M, Choi DY, Cass WA, Bing G. Inflammation and age-related iron accumulation in F344 rats. Curr Aging Sci. 2008, 1(2):112-21. PMID: 20021380

9. Hunter RL, Choi DY, Ross SA, Bing G. Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. Neurosci Lett. 2008, 432(3):198-201. PMCID: PMC2699576, PMID: 18207323

10. Gash DM, Rutland K, Hudson NL, Sullivan PG, Bing G, Cass WA, Pandya JD, Liu M, Choi DY, Hunter RL, Gerhardt GA, Smith CD, Slevin JT, Prince TS. Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity. Ann Neurol. 2008, 63(2):184-92. PMID:18157908

11. Xing B, Xin T, Hunter RL, Bing G. Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. J Neuroinflammation. 2008, 5:4. PMCID: PMC2254610, PMID:18205920

12. Hunter RL, Bing, G. Agonism of peroxisome proliferator receptor-gamma may have therapeutic potential for neuroinflammation and Parkinson's disease. Current Neuropharmacology. 2007, 5(1): 35-46.

13. Xing B, Liu M, Bing G. Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity. J Neuroimmunol. 2007, 192(1-2):89-98. PMID: 17976742

14. Hunter RL, Dragicevic N, Seifert K, Choi DY, Liu M, Kim HC, Cass WA, Sullivan PG, Bing G. Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem. 2007, 100(5):1375-86. PMID: 17254027

15. Arimoto T, Choi DY, Lu X, Liu M, Nguyen XV, Zheng N, Stewart CA, Kim HC, Bing G. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 2007, 28 (6): 894-906. PMID: 16769155.

2006, Jun 10; [Epub ahead of print] PMID: 16769155

16. Bing G, Nguyen XV, Liu M, Markesbery WR, Sun A. Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles. Neurobiol Aging. 2006. PMID: 15946772

17. Liu M, Sun A, Shin EJ, Liu X, Kim SG, Runyons CR, Markesbery W, Kim HC, Bing G. Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. Eur J Neurosci. 2006, 23(8):2027-34. PMID: 16630050

18. Vijitruth R, Liu M, Choi DY, Nguyen XV, Hunter RL, Bing G. Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease. J Neuroinflammation. 2006, 3:6. PMCID: PMC1440849, PMID: 16566823

19. Nguyen XV, Masse J, Kumar A, Vijitruth R, Kulik C, Liu M, Choi DY, Foster TC, Usynin I, Bakalkin G, Bing G. Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance. Behav Brain Res. 2005, 161(2):254-62. PMID: 15922052

20. Zhang J, Stanton DM, Nguyen XV, Liu M, Zhang Z, Gash D, Bing G. Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits. Neuroscience. 2005, 135(3):829-38. PMID: 16165292

21. Sun A, Liu M, Nguyen XV, Bing G. P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp Neurol. 2003, 183(2):394-405. PMID: 14552880

22. Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 2003, 424(6948):556-61. PMID: 12891359

23. Arimoto T, Bing G. Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiol Dis. 2003, 12(1):35-45. PMID: 12609487

24. Sun A, Koelsch G, Tang J, Bing G. Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls. Exp Neurol. 2002, 175(1):10-22. PMID: 12009756

25. Kim HC, Bing G, Jhoo WK, Kim WK, Shin EJ, Park ES, Choi YS, Lee DW, Shin CY, Ryu JR, Ko KH. Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment. Behav Brain Res. 2002, 131(1-2):211-20. PMID: 11844588

26. Sun A, Nguyen XV, Bing G. Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections. J Histochem Cytochem. 2002, 50(4):463-72. PMID: 11897799

27. Sun A, Nguyen XV, Bing G. A novel fluorescent method for direct visualization of neurofibrillary pathology in Alzheimer's disease. J Neurosci Methods. 2001, 111(1):17-27. PMID:

11574116

28. Feng Z, Hong J, Qi Q, Han Y, Wilson B, Iadarola M, Tiao N, Bing G. Cloning and expression of MP13 gene from rat hippocampus, a new factor related to guanosine triphosphate regulation. Neurosci Lett. 2000, 296(2-3):129-32. PMID: 11108998

29. Kim H, Jhoo W, Shin E, Bing G. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain Res. 2000, 862(1-2):247-52. PMID:

10799693

30. Floyd RA, Hensley K, Bing G. Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics. J Neural Transm Suppl. 2000, (60):387-414. Review. PMID: 11205157

31. Lu X, Bing G, Hagg T. Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats. Neuroscience. 2000;97(2):285-91. PMID: 10799760

32. Kim HC, Jhoo WK, Choi DY, Im DH, Shin EJ, Suh JH, Floyd RA, Bing G. Protection of methamphetamine nigrostriatal toxicity by dietary selenium. Brain Res. 1999, 851(1-2):76-86. PMID: 10642830

33. Hensley K, Floyd RA, Zheng NY, Nael R, Robinson KA, Nguyen X, Pye QN, Stewart CA, Geddes J, Markesbery WR, Patel E, Johnson GV, Bing G. p38 kinase is activated in the Alzheimer's disease brain. J Neurochem. 1999, 72(5):2053-8. PMID: 10217284

34. Gupta RP, Bing G, Hong JS, Abou-Donia MB. cDNA cloning and sequencing of Ca2+/calmodulin-dependent protein kinase IIalpha subunit and its mRNA expression in diisopropyl phosphorofluoridate (DFP)-treated hen central nervous system. Mol Cell Biochem. 1998, 181(1-2):29-39. PMID: 9562239

35. Bing G, Wilson B, Hudson P, Jin L, Feng Z, Zhang W, Bing R, Hong JS. A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year. Proc Natl Acad Sci USA 1997, 94(17):9422-7. PMCID: PMC23206, PMID: 9256498

36. Bing G, Wang W, Qi Q, Feng Z, Hudson P, Jin L, Zhang W, Bing R, Hong JS. Long-term expression of Fos-related antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum. J Neurochem. 1997, 68(1):272-9. PMID: 8978735

37. Bing G, Wilson B, McMillian M, Feng Z, Qi Q, Kim H, Wang W, Jensen K, Hong JS. Long-term expression of Proenkephalin and prodynorphin in the rat brain after systemic administration of kainic acid, an in situ hybridization study. In Neurodegenerative Disease, ed. by G. Flskum, Plenum Press, 1996, pp 8-18.

38. Bing G, McMillian M, Kim H, Pennypacker K, Feng Z, Qi Q, Kong LY, Iadarola M, Hong JS. Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment. Neuroscience. 1996, 73(4):1159-74. PMID: 8809832

39. McMillian M, Kong LY, Sawin SM, Wilson B, Das K, Hudson P, Hong JS, Bing G. Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures. Biochem Biophys Res Commun. 1995, 215(2):572-7. PMID: 7487994

40. Bing G, Zhang Y, Watanabe Y, McEwen BS, Stone EA. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain Res. 1994, 668(1-2):261-5. PMID: 7704612

41. Stone EA, Manavalan JS, Basham DA, Bing G. Effect of yohimbine on nerve growth factor mRNA and protein levels in rat hippocampus. Neurosci Lett. 1994, 167(1-2):11-3. PMID: 8177507

42. Stone EA, Zhang Y, John S, Filer D, Bing G. Effect of locus coeruleus lesion on c-fos expression in the cerebral cortex caused by yohimbine injection or stress. Brain Res. 1993, 603(2):181-5. PMID: 8461977

43. Bing G, Stone EA, Zhang Y, Filer D. Immunohistochemical studies of noradrenergic-induced expression of c-fos in the rat CNS. Brain Res. 1992, 592(1-2):57-62. PMID: 1360316

44. Bing G, Chen S, Zhang Y, Hillman D, Stone EA. Noradrenergic-induced expression of c-fos in rat cortex: neuronal localization. Neurosci Lett. 1992, 140(2):260-4. PMID: 1501788

45. Stone EA, Zhang Y, John SM, Bing G. c-Fos response to administration of catecholamines into brain by microdialysis. Neurosci Lett. 1991, 133(1):33-5. PMID: 1791995

46. Bing GY, Filer D, Miller JC, Stone EA. Noradrenergic activation of immediate early genes in rat cerebral cortex. Brain Res Mol Brain Res. 1991, 11(1):43-6. PMID: 1662744

47. Bing G, Notter MF, Hansen JT, Kellogg C, Kordower JH, Gash DM. Cografts of adrenal medulla with C6 glioma cells in rats with 6-hydroxydopamine-induced lesions. Neuroscience. 1990, 34(3):687-97. PMID: 1972269

48. Bing GY, Notter MF, Hansen JT, Gash DM. Comparison of adrenal medullary, carotid body and PC12 cell grafts in 6-OHDA lesioned rats. Brain Res Bull. 1988, 20(3):399-406. PMID: 2896533

PubMed Publications:

Shin, EJ ; Jeong, JH ; Sharma, G.; Sharma, N.; Kim, DJ ; Pham, DT ; Trinh, QD ; Dang, DK ; Nah, SY ; Bing, G.; Kim, HC "Protein kinase Cδ mediates methamphetamine-induced dopaminergic neurotoxicity in mice via activation of microsomal epoxide hydrolase." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 133, (2019): 110761. [PubMed Link] | [ Full text ]
Mai, HN ; Sharma, N.; Jeong, JH ; Shin, EJ ; Pham, DT ; Trinh, QD ; Lee, YJ ; Jang, CG ; Nah, SY ; Bing, G.; Kim, HC "P53 knockout mice are protected from cocaine-induced kindling behaviors via inhibiting mitochondrial oxidative burdens, mitochondrial dysfunction, and proapoptotic changes." Neurochemistry international 124, (2019): 68-81. [PubMed Link] | [ Full text ]
Liu, M.; Shin, EJ ; Dang, DK ; Jin, CH ; Lee, PH ; Jeong, JH ; Park, SJ ; Kim, YS ; Xing, B.; Xin, T.; Bing, G.; Kim, HC "Trichloroethylene and Parkinson's Disease: Risk Assessment." Molecular neurobiology 55, 7 (2018): 6201-6214. [PubMed Link] | [ Full text ]
Dang, DK ; Shin, EJ ; Kim, DJ ; Tran, HQ ; Jeong, JH ; Jang, CG ; Nah, SY ; Jeong, JH ; Byun, JK ; Ko, SK ; Bing, G.; Hong, JS ; Kim, HC "Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor." Journal of neuroinflammation 15, 1 (2018): 52. [PubMed Link] | [ Full text ]
Wang, P.; Dai, H.; Zhang, C.; Tian, J.; Deng, Y.; Zhao, M.; Zhao, M.; Bing, G.; Zhao, L. "Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats." Toxicology 410, (2018): 106-115. [PubMed Link] | [ Full text ]
Liu, M.; Bachstetter, AD ; Cass, WA ; Lifshitz, J.; Bing, G. "Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury." Journal of neurotrauma 34, 2 (2017): 414-422. [PubMed Link] | [ Full text ]
Hunter, R.; Ojha, U.; Bhurtel, S.; Bing, G.; Choi, DY "Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway." Neuroscience research 114, (2017): 62-69. [PubMed Link] | [ Full text ]
Zhang, C.; Deng, Y.; Dai, H.; Zhou, W.; Tian, J.; Bing, G.; Zhao, L. "Effects of dimethyl sulfoxide on the morphology and viability of primary cultured neurons and astrocytes." Brain research bulletin 128, (2017): 34-39. [PubMed Link] | [ Full text ]
Zhang, J.; Dai, H.; Deng, Y.; Tian, J.; Zhang, C.; Hu, Z.; Bing, G.; Zhao, L. "Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats." Toxicology 336, (2015): 17-25. [PubMed Link] | [ Full text ]
Tian, J.; Dai, H.; Deng, Y.; Zhang, J.; Li, Y.; Zhou, J.; Zhao, M.; Zhao, M.; Zhang, C.; Zhang, Y.; Wang, P.; Bing, G.; Zhao, L. "The effect of HMGB1 on sub-toxic chlorpyrifos exposure-induced neuroinflammation in amygdala of neonatal rats." Toxicology 338, (2015): 95-103. [PubMed Link] | [ Full text ]
Dai, H.; Deng, Y.; Zhang, J.; Han, H.; Zhao, M.; Li, Y.; Zhang, C.; Tian, J.; Bing, G.; Zhao, L. "PINK1/Parkin-mediated mitophagy alleviates chlorpyrifos-induced apoptosis in SH-SY5Y cells." Toxicology 334, (2015): 72-80. [PubMed Link] | [ Full text ]
Sauerbeck, A.; Hunter, R.; Bing, G.; Sullivan, PG "Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits." Experimental neurology 234, 1 (2012): 85-94. [PubMed Link] | [ Full text ]
Bregt, DR ; Thomas, TC ; Hinzman, JM ; Cao, T.; Liu, M.; Bing, G.; Gerhardt, GA ; Pauly, JR ; Lifshitz, J. "Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat." Experimental neurology 234, 1 (2012): 8-19. [PubMed Link] | [ Full text ]
Shin, EJ ; Duong, CX ; Nguyen, XT ; Li, Z.; Bing, G.; Bach, JH ; Park, DH ; Nakayama, K.; Ali, SF ; Kanthasamy, AG ; Cadet, JL ; Nabeshima, T.; Kim, HC "Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ." Behavioural brain research 232, 1 (2012): 98-113. [PubMed Link] | [ Full text ]
Sauerbeck, A.; Pandya, J.; Singh, I.; Bittman, K.; Readnower, R.; Bing, G.; Sullivan, P. "Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system." Journal of neuroscience methods 198, 1 (2011): 36-43. [PubMed Link] | [ Full text ]
Sauerbeck, A.; Gao, J.; Readnower, R.; Liu, M.; Pauly, JR ; Bing, G.; Sullivan, PG "Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury." Experimental neurology 227, 1 (2011): 128-35. [PubMed Link] | [ Full text ]
Shin, EJ ; Duong, CX ; Nguyen, XT ; Bing, G.; Bach, JH ; Park, DH ; Nakayama, K.; Ali, SF ; Kanthasamy, AG ; Cadet, JL ; Nabeshima, T.; Kim, HC "PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment." Neurochemistry international 59, 1 (2011): 39-50. [PubMed Link] |
Liu, M.; Bing, G. "Lipopolysaccharide animal models for Parkinson's disease." Parkinson's disease 2011, (2011): 327089. [PubMed Link] | [ Full text ]
Choi, DY ; Zhang, J.; Bing, G. "Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats." Neurobiology of aging 31, 9 (2010): 1649-53. [PubMed Link] | [ Full text ]
Liu, M.; Choi, DY ; Hunter, RL ; Pandya, JD ; Cass, WA ; Sullivan, PG ; Kim, HC ; Gash, DM ; Bing, G. "Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats." Journal of neurochemistry 112, 3 (2010): 773-83. [PubMed Link] | [ Full text ]
Xing, B.; Xin, T.; Zhao, L.; Hunter, RL ; Chen, Y.; Bing, G. "Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity." Journal of neuroimmunology 225, 1-2 (2010): 43-51. [PubMed Link] | [ Full text ]
Nguyen, XV ; Liu, M.; Kim, HC ; Bing, G. "Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP." Experimental neurology 219, 1 (2009): 228-38. [PubMed Link] | [ Full text ]
Hunter, RL ; Cheng, B.; Choi, DY ; Liu, M.; Liu, S.; Cass, WA ; Bing, G. "Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice." Journal of neuroscience research 87, 8 (2009): 1913-21. [PubMed Link] | [ Full text ]
Choi, DY ; Liu, M.; Hunter, RL ; Cass, WA ; Pandya, JD ; Sullivan, PG ; Shin, EJ ; Kim, HC ; Gash, DM ; Bing, G. "Striatal neuroinflammation promotes Parkinsonism in rats." PloS one 4, 5 (2009): e5482. [PubMed Link] | [ Full text ]
Liu, M.; Hunter, R.; Nguyen, XV ; Kim, HC ; Bing, G. "Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment." Journal of neuroscience research 86, 12 (2008): 2792-801. [PubMed Link] | [ Full text ]
Hunter, RL ; Liu, M.; Choi, DY ; Cass, WA ; Bing, G. "Inflammation and age-related iron accumulation in F344 rats." Current aging science 1, 2 (2008): 112-21. [PubMed Link] |
Xing, B.; Xin, T.; Hunter, RL ; Bing, G. "Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt." Journal of neuroinflammation 5, (2008): 4. [PubMed Link] | [ Full text ]
Hunter, RL ; Choi, DY ; Ross, SA ; Bing, G. "Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats." Neuroscience letters 432, 3 (2008): 198-201. [PubMed Link] | [ Full text ]
Gash, DM ; Rutland, K.; Hudson, NL ; Sullivan, PG ; Bing, G.; Cass, WA ; Pandya, JD ; Liu, M.; Choi, DY ; Hunter, RL ; Gerhardt, GA ; Smith, CD ; Slevin, JT ; Prince, TS "Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity." Annals of neurology 63, 2 (2008): 184-92. [PubMed Link] | [ Full text ]
Hunter, RL ; Choi, DY ; Kincer, JF ; Cass, WA ; Bing, G.; Gash, DM "Fenbendazole treatment may influence lipopolysaccharide effects in rat brain." Comparative medicine 57, 5 (2007): 487-92. [PubMed Link] | [ Full text ]
Hunter, RL ; Dragicevic, N.; Seifert, K.; Choi, DY ; Liu, M.; Kim, HC ; Cass, WA ; Sullivan, PG ; Bing, G. "Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system." Journal of neurochemistry 100, 5 (2007): 1375-86. [PubMed Link] | [ Full text ]
Arimoto, T.; Choi, DY ; Lu, X.; Liu, M.; Nguyen, XV ; Zheng, N.; Stewart, CA ; Kim, HC ; Bing, G. "Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra." Neurobiology of aging 28, 6 (2007): 894-906. [PubMed Link] | [ Full text ]
Xing, B.; Liu, M.; Bing, G. "Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity." Journal of neuroimmunology 192, 1-2 (2007): 89-98. [PubMed Link] | [ Full text ]
Vijitruth, R.; Liu, M.; Choi, DY ; Nguyen, XV ; Hunter, RL ; Bing, G. "Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease." Journal of neuroinflammation 3, (2006): 6. [PubMed Link] | [ Full text ]
Bing, G.; Nguyen, XV ; Liu, M.; Markesbery, WR ; Sun, A. "Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles." Neurobiology of aging 27, 6 (2006): 823-30. [PubMed Link] | [ Full text ]
Liu, M.; Sun, A.; Shin, EJ ; Liu, X.; Kim, SG ; Runyons, CR ; Markesbery, W.; Kim, HC ; Bing, G. "Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin." The European journal of neuroscience 23, 8 (2006): 2027-34. [PubMed Link] | [ Full text ]
Nguyen, XV ; Masse, J.; Kumar, A.; Vijitruth, R.; Kulik, C.; Liu, M.; Choi, DY ; Foster, TC ; Usynin, I.; Bakalkin, G.; Bing, G. "Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance." Behavioural brain research 161, 2 (2005): 254-62. [PubMed Link] | [ Full text ]
Zhang, J.; Stanton, DM ; Nguyen, XV ; Liu, M.; Zhang, Z.; Gash, D.; Bing, G. "Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits." Neuroscience 135, 3 (2005): 829-38. [PubMed Link] | [ Full text ]
Salvatore, MF ; Zhang, JL ; Large, DM ; Wilson, PE ; Gash, CR ; Thomas, TC ; Haycock, JW ; Bing, G.; Stanford, JA ; Gash, DM ; Gerhardt, GA "Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra." Journal of neurochemistry 90, 1 (2004): 245-54. [PubMed Link] | [ Full text ]
Sun, A.; Liu, M.; Nguyen, XV ; Bing, G. "P38 MAP kinase is activated at early stages in Alzheimer's disease brain." Experimental neurology 183, 2 (2003): 394-405. [PubMed Link] | [ Full text ]
Arimoto, T.; Bing, G. "Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration." Neurobiology of disease 12, 1 (2003): 35-45. [PubMed Link] | [ Full text ]
Sun, A.; Koelsch, G.; Tang, J.; Bing, G. "Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls." Experimental neurology 175, 1 (2002): 10-22. [PubMed Link] | [ Full text ]
Sun, A.; Nguyen, XV ; Bing, G. "Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 50, 4 (2002): 463-72. [PubMed Link] | [ Full text ]
Sun, A.; Nguyen, XV ; Bing, G. "A novel fluorescent method for direct visualization of neurofibrillary pathology in Alzheimer's disease." Journal of neuroscience methods 111, 1 (2001): 17-27. [PubMed Link] | [ Full text ]