Hiroshi Saito, Ph.D.

Bio / Education: 

Graduate School (PhD)
University of Tokyo, Japan

Research Fellow 
Baylor College of Medicine, Houston, Texas

Selected Publications: 

Starr ME, Takahashi H, Okamura D, Mrazek AA, Ueda J, Stromberg AJ, Evers BM, Esmon CT, Saito H. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal Sepsis. American Journal of Physiology -Heart and Circulatory Physiology 308: H83–H91 (2015) http://www.ncbi.nlm.nih.gov/pubmed/25380813 Full text at: http://ajpheart.physiology.org/cgi/pmidlookup?view=long&pmid=25380813


Starr ME, Saito M, Evers BM, Saito H. Age-associated increase in cytokine production during acute systemic inflammation – II: The role of IL-1β in age-dependent IL-6 production in adipose tissue.  Journal of Gerontology Biological Sciences (2014 Oct 24. pii: glu197. Epub ahead of print)http://www.ncbi.nlm.nih.gov/pubmed/25344820   Full text at: http://biomedgerontology.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=25344820


Starr ME, Steele AM, Saito M, Hacker BJ, Evers BM, Saito H. A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis.  PLOS ONE 9(12): e115705 (2014)  Full text:  http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25531402/

 Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H, Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K, Stamler JS, Kaneki M. S-nitrosylation of SIRT1 functions as a pro-inflammatory switch by increasing acetylation of p53 and p65/RelA. Science Signaling 7(351):p. ra106 (2014)


Starr ME, Saito H. Sepsis in old age: Review of human and animal studies. Aging and Disease 5(2):126-136 (2014) http://www.ncbi.nlm.nih.gov/pubmed/24729938  Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24729938/


Mustain WC, Starr ME, Valentino JD, Cohen DA, Okamura D, Wang C, Evers BM, Saito H. Inflammatory cytokine gene expression in mesenteric adipose adipose tissue during acute experimental colitis. PLOS ONE 8: e83693 p.1-9 (2013) http://www.ncbi.nlm.nih.gov/pubmed/24386254  Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386254/

Starr, M.E.; Hu, Y.; Stromberg, A.J.; Carmical, J.R.; Wood, T.G.; Evers, B.M.; Saito, H. "Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors." Aging Cell 12: 194-206 (2013)

Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. J. Gerontol. Biol. Sci. 68: 652-660 (2013)

Okamura, D.; Starr, M.E.; Lee, E.Y.; Stromberg, A.J.; Evers, B.M.; Saito, H. "Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis." Aging Cell 11: 760-769 (2012)

Starr, M.E.;Saito, H. "Age-related increase in food spilling by laboratory mice may lead to significant overestimation of actual food consumption: implications for studies on dietary restriction, metabolism, and dose calculations." J. Gerontol. Biol. Sci. 67: 1043-1048 (2012)

Takahashi, H.;Okamura, D.;Starr, M.E.;Saito, H.;Evers, B.M. "Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation." Aging Cell 11: 305-314 (2012)

Starr, M.E.;Ueda, J.;Yamamoto, S.;Evers, B.M.;Saito, H. "The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation." Free Radical Biology & Medicine 50: 371-380 (2011)

Starr, M.E.;Ueda, J.;Takahashi, H.;Weiler, H.;Esmon, C.T.;Evers, B.M.;Saito, H. "Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin." Blood 115: 4886-4893 (2010)

Starr, M.E.;Evers, B.M.;Saito, H. "Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6." J. Gerontol. Biol. Sci. 64: 723-730 (2009)

Ueda, J.;Starr, M.E.;Takahashi, H.;Du, J.;Chang, L.Y.;Crapo, J.D.;Evers, B.M.;Saito, H. "Decreased pulmonary extracellular superoxide dismutase during systemic inflammation." Free Radical Biology & Medicine 45: 897-904 (2008)