Hiroshi Saito, Ph.D.

Bio / Education: 

Graduate School (PhD)
University of Tokyo, Japan

Research Fellow 
Baylor College of Medicine, Houston, Texas

Selected Publications: 

Starr ME. Saito H. “Sepsis in old age: Review of human and animal studies”. Aging and Disease (In Press, 2014)

Mustain WC, Starr ME, Valentino JD, Cohen DA, Okamura D, Wang C, Evers BM, Saito H. Inflammatory cytokine gene expression in mesenteric adipose adipose tissue during acute experimental colitis. PLOS ONE 8: e83693 p.1-9 (2013)

Starr, M.E.; Hu, Y.; Stromberg, A.J.; Carmical, J.R.; Wood, T.G.; Evers, B.M.; Saito, H. "Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors." Aging Cell 12: 194-206 (2013)

Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. J. Gerontol. Biol. Sci. 68: 652-660 (2013)

Okamura, D.; Starr, M.E.; Lee, E.Y.; Stromberg, A.J.; Evers, B.M.; Saito, H. "Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis." Aging Cell 11: 760-769 (2012)

Starr, M.E.;Saito, H. "Age-related increase in food spilling by laboratory mice may lead to significant overestimation of actual food consumption: implications for studies on dietary restriction, metabolism, and dose calculations." J. Gerontol. Biol. Sci. 67: 1043-1048 (2012)

Takahashi, H.;Okamura, D.;Starr, M.E.;Saito, H.;Evers, B.M. "Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation." Aging Cell 11: 305-314 (2012)

Starr, M.E.;Ueda, J.;Yamamoto, S.;Evers, B.M.;Saito, H. "The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation." Free Radical Biology & Medicine 50: 371-380 (2011)

Starr, M.E.;Ueda, J.;Takahashi, H.;Weiler, H.;Esmon, C.T.;Evers, B.M.;Saito, H. "Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin." Blood 115: 4886-4893 (2010)

Starr, M.E.;Evers, B.M.;Saito, H. "Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6." J. Gerontol. Biol. Sci. 64: 723-730 (2009)

Ueda, J.;Starr, M.E.;Takahashi, H.;Du, J.;Chang, L.Y.;Crapo, J.D.;Evers, B.M.;Saito, H. "Decreased pulmonary extracellular superoxide dismutase during systemic inflammation." Free Radical Biology & Medicine 45: 897-904 (2008)