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Hollie Swanson, Ph.D.
hswan's picture
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hollie.swanson@uky.edu
8593231463
MN 322
PDF icon Swanson CV 2020.pdf
Position(s): 
Professor
Director, Women's Executive Leadership Development Program
Director, Summer Undergraduate Research Fellowship Programs in Pharmacology and Environmental Health Sciences
Graduate Faculty in Nutritional Sciences
Affiliation(s): 
Pharmacology & Nutritional Sciences
ODEI
Other Affiliation(s): 
Nutritional Sciences Graduate Faculty
Pharmacology and Nutritional Sciences Primary Faculty
Toxicology - Joint Faculty
Pillar Work Group
Interests / Specialties: 
Cancer & Education
Bio / Education: 

Ph.D., 1991, Purdue University, West Lafayette, IN
Food Science/Toxicology

M.S., 1988, Oregon State University, Corvallis, OR
Food Science/Food Toxicology

B.S., 1985, South Dakota State University,
Brookings, SD, Chemistry

Research Description: 

My research interests in the past 20 years have focused on environmental toxicology, drug metabolism and nuclear receptors-particularly, the aryl hydrocarbon receptor. On-going projects in my laboratory include study of the potential adverse effects of e-cigarettes. In addition, we are interested in perfluorinated chemicals which are a group of manufactured compounds and are thought to activate or inhibit a number of nuclear receptors. Finally, we are collaborating with Dr. Kevin Pearson as part of the University of Kentucky Superfund project to understand how polychorinated biphenyls may interfere with endocrine signaling and thereby alter muscle and body fat composition.

My educational activities are primarily centered around pharmacology, but I have also taught a course on endocrine disruptors in the Honor's College for several years. I teach pharmacology to medical, dental, graduate and undergraduate students. In the fall, I teach a course to undergraduate student and graduate students (PHA 422G) that is designed to cover the fundamentals of pharmacology using lectures and case based studies. My course in the spring (PHA 423, The Dark Side of Medicine) focuses on "what could possibly go wrong" with respect to drug therapy. It is my hope that this course can help pre-professional students better prepare for their future careers. I enjoy exploring avenues for combining both my research and educational activities to enhance student learning and help prepare students for successful science-related careers. Towards this end, several of my current presentations and publications have focused on the scholarship of teaching and learning.

PubMed Publications: 
  • Jackson, EN ; Thatcher, SE ; Larian, N.; English, V.; Soman, S.; Morris, AJ ; Weng, J.; Stromberg, A.; Swanson, HI ; Pearson, K.; Cassis, LA "Effects of Aryl Hydrocarbon Receptor Deficiency on PCB-77-Induced Impairment of Glucose Homeostasis during Weight Loss in Male and Female Obese Mice." Environmental health perspectives 127, 7 (2019): 77004. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Sarge, OP ; Rodrigo-Peiris, T.; Xiang, L.; Cassone, VM "Development of a Course-Based Undergraduate Research Experience to Introduce Drug-Receptor Concepts." Journal of medical education and curricular development 3, (2016): [PubMed Link] | [ Full text ]
  • Davies, JT ; Delfino, SF ; Feinberg, CE ; Johnson, MF ; Nappi, VL ; Olinger, JT ; Schwab, AP ; Swanson, HI "Current and Emerging Uses of Statins in Clinical Therapeutics: A Review." Lipid insights 9, (2016): 13-29. [PubMed Link] | [ Full text ]
  • Swanson, HI "Drug Metabolism by the Host and Gut Microbiota: A Partnership or Rivalry?" Drug metabolism and disposition: the biological fate of chemicals 43, 10 (2015): 1499-504. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Choi, EY ; Helton, WB ; Gairola, CG ; Valentino, J. "Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma." Oral surgery, oral medicine, oral pathology and oral radiology 117, 2 (2014): 214-20. [PubMed Link] | [ Full text ]
  • Baker, NA ; Karounos, M.; English, V.; Fang, J.; Wei, Y.; Stromberg, A.; Sunkara, M.; Morris, AJ ; Swanson, HI ; Cassis, LA "Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice." Environmental health perspectives 121, 1 (2013): 105-10. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Wada, T.; Xie, W.; Renga, B.; Zampella, A.; Distrutti, E.; Fiorucci, S.; Kong, B.; Thomas, AM ; Guo, GL ; Narayanan, R.; Yepuru, M.; Dalton, JT ; Chiang, JY "Role of nuclear receptors in lipid dysfunction and obesity-related diseases." Drug metabolism and disposition: the biological fate of chemicals 41, 1 (2013): 1-11. [PubMed Link] | [ Full text ]
  • Moirangthem, V.; Katz, WS ; Su, W.; Choi, EY ; Dingle, RW ; Zeigler, GM ; Everson, WV ; Jennings, CD ; Gong, M.; Swanson, HI "Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing." Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 65, 1-2 (2013): 61-7. [PubMed Link] | [ Full text ]
  • Choi, EY ; Lee, H.; Dingle, RW ; Kim, KB ; Swanson, HI "Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor." Molecular pharmacology 81, 1 (2012): 3-11. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Njar, VC ; Yu, Z.; Castro, DJ ; Gonzalez, FJ ; Williams, DE ; Huang, Y.; Kong, AN ; Doloff, JC ; Ma, J.; Waxman, DJ ; Scott, EE "Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy." Drug metabolism and disposition: the biological fate of chemicals 38, 4 (2010): 539-44. [PubMed Link] | [ Full text ]
  • Ray, S.; Swanson, HI "Activation of the aryl hydrocarbon receptor by TCDD inhibits senescence: a tumor promoting event?" Biochemical pharmacology 77, 4 (2009): 681-8. [PubMed Link] | [ Full text ]
  • Puppala, D.; Lee, H.; Kim, KB ; Swanson, HI "Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention." Molecular pharmacology 73, 4 (2008): 1064-71. [PubMed Link] | [ Full text ]
  • Puppala, D.; Gairola, CG ; Swanson, HI "Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation." Carcinogenesis 28, 3 (2007): 639-47. [PubMed Link] | [ Full text ]
  • Wu, R.; Zhang, L.; Hoagland, MS ; Swanson, HI "Lack of the aryl hydrocarbon receptor leads to impaired activation of AKT/protein kinase B and enhanced sensitivity to apoptosis induced via the intrinsic pathway." The Journal of pharmacology and experimental therapeutics 320, 1 (2007): 448-57. [PubMed Link] | [ Full text ]
  • Zhang, L.; Wu, R.; Dingle, RW ; Gairola, CG ; Valentino, J.; Swanson, HI "Cigarette smoke condensate and dioxin suppress culture shock induced senescence in normal human oral keratinocytes." Oral oncology 43, 7 (2007): 693-700. [PubMed Link] | [ Full text ]
  • Hoagland, MS ; Hoagland, EM ; Swanson, HI "The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor." The Journal of pharmacology and experimental therapeutics 314, 2 (2005): 603-10. [PubMed Link] | [ Full text ]
  • Wache, SC ; Hoagland, EM ; Zeigler, G.; Swanson, HI "Role of arginine residues 14 and 15 in dictating DNA binding stability and transactivation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator heterodimer." Gene expression 12, 4-6 (2005): 231-43. [PubMed Link] |
  • Swanson, HI "Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective." Chemico-biological interactions 149, 2-3 (2004): 69-79. [PubMed Link] | [ Full text ]
  • Ray, SS ; Swanson, HI "Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a." The Journal of biological chemistry 279, 26 (2004): 27187-93. [PubMed Link] | [ Full text ]
  • Ray, SS ; Swanson, HI "Alteration of keratinocyte differentiation and senescence by the tumor promoter dioxin." Toxicology and applied pharmacology 192, 2 (2003): 131-45. [PubMed Link] | [ Full text ]
  • Swanson, HI "DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation." Chemico-biological interactions 141, 1-2 (2002): 63-76. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Whitelaw, ML ; Petrulis, JR ; Perdew, GH "Use of 125I 4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior." Journal of biochemical and molecular toxicology 16, 6 (2002): 298-310. [PubMed Link] | [ Full text ]
  • Heid, SE ; Walker, MK ; Swanson, HI "Correlation of cardiotoxicity mediated by halogenated aromatic hydrocarbons to aryl hydrocarbon receptor activation." Toxicological sciences : an official journal of the Society of Toxicology 61, 1 (2001): 187-96. [PubMed Link] | [ Full text ]
  • Walker, MK ; Heid, SE ; Smith, SM ; Swanson, HI "Molecular characterization and developmental expression of the aryl hydrocarbon receptor from the chick embryo." Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 126, 3 (2000): 305-19. [PubMed Link] |
  • Klinge, CM ; Kaur, K.; Swanson, HI "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1." Archives of biochemistry and biophysics 373, 1 (2000): 163-74. [PubMed Link] | [ Full text ]
  • Heid, SE ; Pollenz, RS ; Swanson, HI "Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor." Molecular pharmacology 57, 1 (2000): 82-92. [PubMed Link] | [ Full text ]
  • Klinge, CM ; Bowers, JL ; Kulakosky, PC ; Kamboj, KK ; Swanson, HI "The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements." Molecular and cellular endocrinology 157, 1-2 (1999): 105-19. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Yang, JH "Specificity of DNA binding of the c-Myc/Max and ARNT/ARNT dimers at the CACGTG recognition site." Nucleic acids research 27, 15 (1999): 3205-12. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Yang, JH "The aryl hydrocarbon receptor interacts with transcription factor IIB." Molecular pharmacology 54, 4 (1998): 671-7. [PubMed Link] | [ Full text ]
  • Byrd DM, 3rd ; Allen, DO ; Beamer, RL ; Besch HR, Jr ; Bylund, DB ; Doull, J.; Fleming, WW ; Fries, A.; Guengerich, FP ; Hornbrook, R.; Lasagna, L.; Lum, BK ; Michaelis, EK ; Morgan, ET ; Poland, A.; Rozman, KK ; Smith, JB ; Swanson, HI ; Waddell, W.; Wilson, JD "The dose-response model for dioxin." Risk analysis : an official publication of the Society for Risk Analysis 18, 1 (1998): 1-2. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Yang, JH "Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator." The Journal of biological chemistry 271, 49 (1996): 31657-65. [PubMed Link] |
  • Swanson, HI ; Chan, WK ; Bradfield, CA "DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins." The Journal of biological chemistry 270, 44 (1995): 26292-302. [PubMed Link] |
  • Bank, PA ; Yao, EF ; Swanson, HI ; Tullis, K.; Denison, MS "DNA binding of the transformed guinea pig hepatic Ah receptor complex: identification and partial characterization of two high-affinity DNA-binding forms." Archives of biochemistry and biophysics 317, 2 (1995): 439-48. [PubMed Link] | [ Full text ]
  • Dolwick, KM ; Swanson, HI ; Bradfield, CA "In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition." Proceedings of the National Academy of Sciences of the United States of America 90, 18 (1993): 8566-70. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Bradfield, CA "The AH-receptor: genetics, structure and function." Pharmacogenetics 3, 5 (1993): 213-30. [PubMed Link] |
  • Swanson, HI ; Tullis, K.; Denison, MS "Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: evidence for two distinct heteromeric DNA-binding forms." Biochemistry 32, 47 (1993): 12841-9. [PubMed Link] |
  • Dolwick, KM ; Schmidt, JV ; Carver, LA ; Swanson, HI ; Bradfield, CA "Cloning and expression of a human Ah receptor cDNA." Molecular pharmacology 44, 5 (1993): 911-7. [PubMed Link] | [ Full text ]
  • Schafer, MW ; Madhukar, BV ; Swanson, HI ; Tullis, K.; Denison, MS "Protein kinase C is not involved in Ah receptor transformation and DNA binding." Archives of biochemistry and biophysics 307, 2 (1993): 267-71. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Perdew, GH "Half-life of aryl hydrocarbon receptor in Hepa 1 cells: evidence for ligand-dependent alterations in cytosolic receptor levels." Archives of biochemistry and biophysics 302, 1 (1993): 167-74. [PubMed Link] | [ Full text ]
  • Swanson, HI ; Perdew, GH "Detection of the Ah receptor in rainbow trout: use of 2-azido-3- 125I iodo-7,8-dibromodibenzo-p-dioxin in cell culture." Toxicology letters 58, 1 (1991): 85-95. [PubMed Link] | [ Full text ]
  • Fong, AT ; Swanson, HI ; Dashwood, RH ; Williams, DE ; Hendricks, JD ; Bailey, GS "Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation." Biochemical pharmacology 39, 1 (1990): 19-26. [PubMed Link] | [ Full text ]
Trustee Statement

My nearly 25 years as faculty member at the University of Kentucky has provided me with invaluable insights into the strengths and challenges of the commonwealth that we serve. As a researcher and educator, I have gained a good understanding of the needs of the faculty as we seek new discoveries and inspire the next generation. As a member of the University Senate and Senate Council, I have been consistently impressed by the compassion and high standards of my faculty colleagues as they represent their disciplines, departments and colleges. I have been honored to serve as the chair of both the University Senate Council and the College of Medicine Faculty Council where we have addressed the many difficult issues that challenge our institutions of higher education and academic medical centers. In addition, I have chaired several university-wide committees that have focused on key, university-wide issues. This includes the Review Committee (2011) that assessed the status of the University of Kentucky and laid the foundation for many of the positive changes that have transformed our campus. In these leadership roles, I have sought to listen carefully to those who express diverse opinions, develop consensus and practice shared leadership such that in my role as the leader, I could be confident that I truly served as the voice of the faculty. More recently, I have been privileged to lead the Women’s Executive Leadership Development program which has allowed me to interact with an impressive group of campus leaders, identify their needs and provide them with support as they prepare themselves for undertaking new challenges.
With my breadth of leadership experiences I am uniquely poised to serve as your faculty trustee. As your trustee, I promise to represent you with a strong work ethic, integrity, honesty and transparency.

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