James W Geddes, PhD

Connect
About
Publications

Primary Contact: Jennifer Steinman
(859) 218-4093
MN 144 Willard Med Sci Bldg

Position(s):

Vice Dean for Research, College of Medicine

Professor, Dept. Neuroscience

Faculty, Spinal Cord and Brain Injury Research Center (SCoBIRC)

Affiliation(s):

Spinal Cord and Brain Injury Research Center

Neuroscience

Other Affiliation(s):

SCOBIRC - Core Faculty

Admin Personnel

PubMed Publications:

Ghoshal, S.; Bondada, V.; Saatman, KE ; Guttmann, RP ; Geddes, JW "Phage display for identification of serum biomarkers of traumatic brain injury." Journal of neuroscience methods 272, (2016): 33-37. [PubMed Link] | [ Full text ]
Schaefer, KA ; Toral, MA ; Velez, G.; Cox, AJ ; Baker, SA ; Borcherding, NC ; Colgan, DF ; Bondada, V.; Mashburn, CB ; Yu, CG ; Geddes, JW ; Tsang, SH ; Bassuk, AG ; Mahajan, VB "Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses." Investigative ophthalmology & visual science 57, 6 (2016): 2509-21. [PubMed Link] | [ Full text ]
Kulbe, JR ; Geddes, JW "Current status of fluid biomarkers in mild traumatic brain injury." Experimental neurology 275 Pt 3, (2016): 334-352. [PubMed Link] | [ Full text ]
Meyer, CA ; Singh, R.; Jones, MT ; Yu, CG ; Power, RF ; Geddes, JW "Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression, but Does Not Improve Locomotor Function, following Spinal Cord Injury." PloS one 11, 1 (2016): e0147716. [PubMed Link] | [ Full text ]
Kim, DY ; Simeone, KA ; Simeone, TA ; Pandya, JD ; Wilke, JC ; Ahn, Y.; Geddes, JW ; Sullivan, PG ; Rho, JM "Ketone bodies mediate antiseizure effects through mitochondrial permeability transition." Annals of neurology 78, 1 (2015): 77-87. [PubMed Link] | [ Full text ]
Chotibut, T.; Davis, RW ; Arnold, JC ; Frenchek, Z.; Gurwara, S.; Bondada, V.; Geddes, JW ; Salvatore, MF "Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model." Molecular neurobiology 49, 3 (2014): 1282-92. [PubMed Link] | [ Full text ]
Singh, R.; Brewer, MK ; Mashburn, CB ; Lou, D.; Bondada, V.; Graham, B.; Geddes, JW "Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies." The Journal of biological chemistry 289, 28 (2014): 19383-94. [PubMed Link] | [ Full text ]
Yu, CG ; Singh, R.; Crowdus, C.; Raza, K.; Kincer, J.; Geddes, JW "Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury." Neuroscience 256, (2014): 163-9. [PubMed Link] | [ Full text ]
Yu, CG ; Li, Y.; Raza, K.; Yu, XX ; Ghoshal, S.; Geddes, JW "Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats." Journal of neurotrauma 30, 6 (2013): 427-33. [PubMed Link] | [ Full text ]
Bains, M.; Cebak, JE ; Gilmer, LK ; Barnes, CC ; Thompson, SN ; Geddes, JW ; Hall, ED "Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model." Journal of neurochemistry 125, 1 (2013): 125-32. [PubMed Link] | [ Full text ]
Avery, MA ; Rooney, TM ; Pandya, JD ; Wishart, TM ; Gillingwater, TH ; Geddes, JW ; Sullivan, PG ; Freeman, MR "WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering." Current biology : CB 22, 7 (2012): 596-600. [PubMed Link] | [ Full text ]
Blalock, EM ; Buechel, HM ; Popovic, J.; Geddes, JW ; Landfield, PW "Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease." Journal of chemical neuroanatomy 42, 2 (2011): 118-26. [PubMed Link] | [ Full text ]
Naga, KK ; Geddes, JW "Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release." Neuromolecular medicine 13, 1 (2011): 31-6. [PubMed Link] | [ Full text ]
Reneer, DV ; Hisel, RD ; Hoffman, JM ; Kryscio, RJ ; Lusk, BT ; Geddes, JW "A multi-mode shock tube for investigation of blast-induced traumatic brain injury." Journal of neurotrauma 28, 1 (2011): 95-104. [PubMed Link] | [ Full text ]
Cullen, DK ; Xu, Y.; Reneer, DV ; Browne, KD ; Geddes, JW ; Yang, S.; Smith, DH "Color changing photonic crystals detect blast exposure." NeuroImage 54 Suppl 1, (2011): S37-44. [PubMed Link] | [ Full text ]
Geddes, JW ; Saatman, KE "Targeting individual calpain isoforms for neuroprotection." Experimental neurology 226, 1 (2010): 6-7. [PubMed Link] | [ Full text ]
Yu, CG ; Yezierski, RP ; Joshi, A.; Raza, K.; Li, Y.; Geddes, JW "Involvement of ERK2 in traumatic spinal cord injury." Journal of neurochemistry 113, 1 (2010): 131-42. [PubMed Link] | [ Full text ]
Nasr, P.; Carbery, T.; Geddes, JW "N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity." Neurochemical research 34, 3 (2009): 490-8. [PubMed Link] | [ Full text ]
Li, Y.; Bondada, V.; Joshi, A.; Geddes, JW "Calpain 1 and Calpastatin expression is developmentally regulated in rat brain." Experimental neurology 220, 2 (2009): 316-9. [PubMed Link] | [ Full text ]
Geddes, JW ; Sullivan, PG "Special Issue: Mitochondria and neurodegeneration." Experimental neurology 218, 2 (2009): 169-70. [PubMed Link] | [ Full text ]
Joshi, A.; Bondada, V.; Geddes, JW "Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor." Experimental neurology 218, 2 (2009): 221-7. [PubMed Link] | [ Full text ]
Yu, CG ; Joshi, A.; Geddes, JW "Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury." Journal of neurotrauma 25, 7 (2008): 833-40. [PubMed Link] | [ Full text ]
Badugu, R.; Garcia, M.; Bondada, V.; Joshi, A.; Geddes, JW "N terminus of calpain 1 is a mitochondrial targeting sequence." The Journal of biological chemistry 283, 6 (2008): 3409-17. [PubMed Link] | [ Full text ]
Zhang, SX ; Holmberg, EG ; Geddes, JW "Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde." Journal of neuroscience methods 163, 1 (2007): 38-43. [PubMed Link] | [ Full text ]
Naga, KK ; Sullivan, PG ; Geddes, JW "High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 28 (2007): 7469-75. [PubMed Link] | [ Full text ]
Yu, CG ; Geddes, JW "Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury." Neurochemical research 32, 12 (2007): 2046-53. [PubMed Link] | [ Full text ]
Brown, MR ; Sullivan, PG ; Geddes, JW "Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria." The Journal of biological chemistry 281, 17 (2006): 11658-68. [PubMed Link] | [ Full text ]
Brown, MR ; Bondada, V.; Keller, JN ; Thorpe, J.; Geddes, JW "Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons." Journal of Alzheimer's disease : JAD 7, 1 (2005): 15-24. [PubMed Link] | [ Full text ]
Ravikumar, R.; Fugaccia, I.; Scheff, SW ; Geddes, JW ; Srinivasan, C.; Toborek, M. "Nicotine attenuates morphological deficits in a contusion model of spinal cord injury." Journal of neurotrauma 22, 2 (2005): 240-51. [PubMed Link] | [ Full text ]
Garcia, M.; Bondada, V.; Geddes, JW "Mitochondrial localization of mu-calpain." Biochemical and biophysical research communications 338, 2 (2005): 1241-7. [PubMed Link] | [ Full text ]
Geddes, JW "alpha-Synuclein: a potent inducer of tau pathology." Experimental neurology 192, 2 (2005): 244-50. [PubMed Link] | [ Full text ]
Zhang, SX ; Geddes, JW ; Owens, JL ; Holmberg, EG "X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord." Histology and histopathology 20, 2 (2005): 519-30. [PubMed Link] | [ Full text ]
Ravikumar, R.; Flora, G.; Geddes, JW ; Hennig, B.; Toborek, M. "Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma." Brain research. Molecular brain research 124, 2 (2004): 188-98. [PubMed Link] | [ Full text ]
Sengoku, T.; Bondada, V.; Hassane, D.; Dubal, S.; Geddes, JW "Tat-calpastatin fusion proteins transduce primary rat cortical neurons but do not inhibit cellular calpain activity." Experimental neurology 188, 1 (2004): 161-70. [PubMed Link] | [ Full text ]
Blalock, EM ; Geddes, JW ; Chen, KC ; Porter, NM ; Markesbery, WR ; Landfield, PW "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses." Proceedings of the National Academy of Sciences of the United States of America 101, 7 (2004): 2173-8. [PubMed Link] | [ Full text ]
Brown, MR ; Sullivan, PG ; Dorenbos, KA ; Modafferi, EA ; Geddes, JW ; Steward, O. "Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria." Journal of neuroscience methods 137, 2 (2004): 299-303. [PubMed Link] | [ Full text ]
Brown, MR ; Geddes, JW ; Sullivan, PG "Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium." Journal of bioenergetics and biomembranes 36, 4 (2004): 401-6. [PubMed Link] |
Pang, Z.; Bondada, V.; Sengoku, T.; Siman, R.; Geddes, JW "Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology." Journal of neuropathology and experimental neurology 62, 6 (2003): 633-43. [PubMed Link] |
Nasr, P.; Gursahani, HI ; Pang, Z.; Bondada, V.; Lee, J.; Hadley, RW ; Geddes, JW "Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid." Neurochemistry international 43, 2 (2003): 89-99. [PubMed Link] | [ Full text ]
Zhang, SX ; Bondada, V.; Geddes, JW "Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection." Journal of neurotrauma 20, 1 (2003): 59-67. [PubMed Link] | [ Full text ]
Bu, J.; Bruckner, SR ; Sengoku, T.; Geddes, JW ; Estus, S. "Glutamate regulates caveolin expression in rat hippocampal neurons." Journal of neuroscience research 72, 2 (2003): 185-90. [PubMed Link] | [ Full text ]
LaFontaine, MA ; Geddes, JW ; Butterfield, DA "3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease." Neurochemical research 27, 6 (2002): 507-11. [PubMed Link] |
Aksenova, M.; Butterfield, DA ; Zhang, SX ; Underwood, M.; Geddes, JW "Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury." Journal of neurotrauma 19, 4 (2002): 491-502. [PubMed Link] | [ Full text ]
Aksenov, MY ; Aksenova, MV ; Butterfield, DA ; Geddes, JW ; Markesbery, WR "Protein oxidation in the brain in Alzheimer's disease." Neuroscience 103, 2 (2001): 373-83. [PubMed Link] | [ Full text ]
Fontaine, MA ; Geddes, JW ; Banks, A.; Butterfield, DA "Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease." Journal of neurochemistry 75, 4 (2000): 1709-15. [PubMed Link] | [ Full text ]
La Fontaine, MA ; Geddes, JW ; Banks, A.; Butterfield, DA "3-nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease." Brain research 858, 2 (2000): 356-62. [PubMed Link] | [ Full text ]
Zhang, SX ; Underwood, M.; Landfield, A.; Huang, FF ; Gison, S.; Geddes, JW "Cytoskeletal disruption following contusion injury to the rat spinal cord." Journal of neuropathology and experimental neurology 59, 4 (2000): 287-96. [PubMed Link] |
Tekirian, TL ; Yang, AY ; Glabe, C.; Geddes, JW "Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42." Journal of neurochemistry 73, 4 (1999): 1584-9. [PubMed Link] | [ Full text ]
Geddes, JW ; Chang, NG ; Ackley, DC ; Soultanian, NS ; McGillis, JP ; Yokel, RA "Postmortem elevation in extracellular glutamate in the rat hippocampus when brain temperature is maintained at physiological levels: implications for the use of human brain autopsy tissues." Brain research 831, 1-2 (1999): 104-12. [PubMed Link] | [ Full text ]
Geddes, JW ; Tekirian, TL ; Mattson, MP "N-terminus truncated beta-amyloid peptides and C-terminus truncated secreted forms of amyloid precursor protein: distinct roles in the pathogenesis of Alzheimer's disease." Neurobiology of aging 20, 1 (1999): 75-9; discussion 87. [PubMed Link] | [ Full text ]
Bruce-Keller, AJ ; Geddes, JW ; Knapp, PE ; McFall, RW ; Keller, JN ; Holtsberg, FW ; Parthasarathy, S.; Steiner, SM ; Mattson, MP "Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD." Journal of neuroimmunology 93, 1-2 (1999): 53-71. [PubMed Link] | [ Full text ]
Endres, M.; Fink, K.; Zhu, J.; Stagliano, NE ; Bondada, V.; Geddes, JW ; Azuma, T.; Mattson, MP ; Kwiatkowski, DJ ; Moskowitz, MA "Neuroprotective effects of gelsolin during murine stroke." The Journal of clinical investigation 103, 3 (1999): 347-54. [PubMed Link] | [ Full text ]
Maragos, WF ; Jakel, RJ ; Chesnut, MD ; Geddes, JW ; Dwoskin, LP "Does dopamine contribute to striatal damage caused by impaired mitochondrial function?" Annals of the New York Academy of Sciences 893, (1999): 345-9. [PubMed Link] | [ Full text ]
Carman, HM ; Dhillon, HS ; Zhang, D.; Geddes, JW ; Prasad, RM "Regional levels of phospholipase Cgamma after fluid percussion brain injury in the rat." Brain research 808, 1 (1998): 116-9. [PubMed Link] | [ Full text ]
Ashford, JW ; Soultanian, NS ; Zhang, SX ; Geddes, JW "Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain." Journal of neuropathology and experimental neurology 57, 10 (1998): 972-8. [PubMed Link] |
Minger, SL ; Geddes, JW ; Holtz, ML ; Craddock, SD ; Whiteheart, SW ; Siman, RG ; Pettigrew, LC "Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia." Brain research 810, 1-2 (1998): 181-99. [PubMed Link] | [ Full text ]
Tekirian, TL ; Saido, TC ; Markesbery, WR ; Russell, MJ ; Wekstein, DR ; Patel, E.; Geddes, JW "N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits." Journal of neuropathology and experimental neurology 57, 1 (1998): 76-94. [PubMed Link] |
Maragos, WF ; Jakel, RJ ; Pang, Z.; Geddes, JW "6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions." Experimental neurology 154, 2 (1998): 637-44. [PubMed Link] | [ Full text ]
Guo, Q.; Fu, W.; Xie, J.; Luo, H.; Sells, SF ; Geddes, JW ; Bondada, V.; Rangnekar, VM ; Mattson, MP "Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease." Nature medicine 4, 8 (1998): 957-62. [PubMed Link] |
Springer, JE ; Azbill, RD ; Kennedy, SE ; George, J.; Geddes, JW "Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment." Journal of neurochemistry 69, 4 (1997): 1592-600. [PubMed Link] | [ Full text ]
Geddes, JW ; Panchalingam, K.; Keller, JN ; Pettegrew, JW "Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions." Neurobiology of aging 18, 3 (1997): 305-8. [PubMed Link] | [ Full text ]
Pang, Z.; Geddes, JW "Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 9 (1997): 3064-73. [PubMed Link] | [ Full text ]
Geddes, JW ; Tekirian, TL ; Soultanian, NS ; Ashford, JW ; Davis, DG ; Markesbery, WR "Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease." Neurobiology of aging 18, 4 Suppl (1997): S99-105. [PubMed Link] | [ Full text ]
Keller, JN ; Pang, Z.; Geddes, JW ; Begley, JG ; Germeyer, A.; Waeg, G.; Mattson, MP "Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal." Journal of neurochemistry 69, 1 (1997): 273-84. [PubMed Link] | [ Full text ]
Mark, RJ ; Pang, Z.; Geddes, JW ; Uchida, K.; Mattson, MP "Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 3 (1997): 1046-54. [PubMed Link] | [ Full text ]
Pettigrew, LC ; Holtz, ML ; Craddock, SD ; Minger, SL ; Hall, N.; Geddes, JW "Microtubular proteolysis in focal cerebral ischemia." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 16, 6 (1996): 1189-202. [PubMed Link] | [ Full text ]
Geddes, JW ; Pang, Z.; Wiley, DH "Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease." Molecular and chemical neuropathology 28, 1-3 (1996): 65-74. [PubMed Link] |
Russell, MJ ; Bobik, M.; White, RG ; Hou, Y.; Benjamin, SA ; Geddes, JW "Age-specific onset of beta-amyloid in beagle brains." Neurobiology of aging 17, 2 (1996): 269-73. [PubMed Link] | [ Full text ]
Tekirian, TL ; Cole, GM ; Russell, MJ ; Yang, F.; Wekstein, DR ; Patel, E.; Snowdon, DA ; Markesbery, WR ; Geddes, JW "Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains." Neurobiology of aging 17, 2 (1996): 249-57. [PubMed Link] | [ Full text ]
Geddes, JW ; Pettigrew, LC ; Holtz, ML ; Craddock, SD ; Maines, MD "Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain." Neuroscience letters 210, 3 (1996): 205-8. [PubMed Link] | [ Full text ]
Pang, Z.; Umberger, GH ; Geddes, JW "Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801." Journal of neurochemistry 66, 2 (1996): 474-84. [PubMed Link] | [ Full text ]
Mattson, MP ; Cheng, B.; Baldwin, SA ; Smith-Swintosky, VL ; Keller, J.; Geddes, JW ; Scheff, SW ; Christakos, S. "Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response." Journal of neuroscience research 42, 3 (1995): 357-70. [PubMed Link] | [ Full text ]
Geddes, JW ; Bondada, V.; Tekirian, TL ; Pang, Z.; Siman, RG "Perikaryal accumulation and proteolysis of neurofilament proteins in the post-mortem rat brain." Neurobiology of aging 16, 4 (1995): 651-60. [PubMed Link] | [ Full text ]
Geddes, JW ; Schwab, C.; Craddock, S.; Wilson, JL ; Pettigrew, LC "Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 14, 4 (1994): 554-64. [PubMed Link] | [ Full text ]
Geddes, JW ; Bondada, V.; Keller, JN "Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2." Brain research 633, 1-2 (1994): 1-8. [PubMed Link] | [ Full text ]
Schwab, C.; Bondada, V.; Sparks, DL ; Cahan, LD ; Geddes, JW "Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus." Hippocampus 4, 2 (1994): 210-25. [PubMed Link] | [ Full text ]
Geddes, JW ; Ułas, J.; Brunner, LC ; Choe, W.; Cotman, CW "Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors." Neuroscience 50, 1 (1992): 23-34. [PubMed Link] | [ Full text ]
Cummings, BJ ; Su, JH ; Geddes, JW ; Van Nostrand, WE ; Wagner, SL ; Cunningham, DD ; Cotman, CW "Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease." Neuroscience 48, 4 (1992): 763-77. [PubMed Link] | [ Full text ]
Ułas, J.; Brunner, LC ; Geddes, JW ; Choe, W.; Cotman, CW "N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease." Neuroscience 49, 1 (1992): 45-61. [PubMed Link] | [ Full text ]
Geddes, JW ; Brunner, L.; Cotman, CW ; Buzsaki, G. "Alterations in 3H kainate and N-methyl-D-aspartate-sensitive L- 3H -glutamate binding in the rat hippocampal formation following fimbria-fornix lesions." Experimental neurology 115, 2 (1992): 271-81. [PubMed Link] | [ Full text ]
Russell, MJ ; White, R.; Patel, E.; Markesbery, WR ; Watson, CR ; Geddes, JW "Familial influence on plaque formation in the beagle brain." Neuroreport 3, 12 (1992): 1093-6. [PubMed Link] |
Geddes, JW ; Lundgren, K.; Kim, YK "Aberrant localization of MAP5 immunoreactivity in the hippocampal formation in Alzheimer's disease." Journal of neuroscience research 30, 1 (1991): 183-91. [PubMed Link] | [ Full text ]
Geddes, JW ; Cotman, CW "Plasticity in Alzheimer's disease: too much or not enough?" Neurobiology of aging 12, 4 (1991): 330-3; discussion 352-5. [PubMed Link] | [ Full text ]
Johnson, BA ; Shirokawa, JM ; Geddes, JW ; Choi, BH ; Kim, RC ; Aswad, DW "Protein L-isoaspartyl methyltransferase in postmortem brains of aged humans." Neurobiology of aging 12, 1 (1991): 19-24. [PubMed Link] | [ Full text ]
Vijayan, VK ; Geddes, JW ; Anderson, KJ ; Chang-Chui, H.; Ellis, WG ; Cotman, CW "Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation." Experimental neurology 112, 1 (1991): 72-8. [PubMed Link] |
Russell, MJ ; Vijayan, VK ; Gibbs, RB ; Geddes, JW ; Jacobson, CH ; Cotman, CW "Long-term survival of neural transplants to senescence in rats." Experimental neurology 108, 2 (1990): 105-8. [PubMed Link] | [ Full text ]
Geddes, JW ; Cahan, LD ; Cooper, SM ; Kim, RC ; Choi, BH ; Cotman, CW "Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy." Experimental neurology 108, 3 (1990): 214-20. [PubMed Link] |
Geddes, JW ; Wong, J.; Choi, BH ; Kim, RC ; Cotman, CW ; Miller, FD "Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease." Neuroscience letters 109, 1-2 (1990): 54-61. [PubMed Link] | [ Full text ]
Cotman, CW ; Geddes, JW ; Kahle, JS "Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?" Progress in brain research 83, (1990): 427-34. [PubMed Link] | [ Full text ]
Miller, FD ; Geddes, JW "Increased expression of the major embryonic alpha-tubulin mRNA, T alpha 1, during neuronal regeneration, sprouting, and in Alzheimer's disease." Progress in brain research 86, (1990): 321-30. [PubMed Link] | [ Full text ]
Geddes, JW ; Wilson, MC ; Miller, FD ; Cotman, CW "Molecular markers of reactive plasticity." Advances in experimental medicine and biology 268, (1990): 425-32. [PubMed Link] |
Cotman, CW ; Geddes, JW ; Ulas, J.; Klein, M. "Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease." Progress in brain research 86, (1990): 55-61. [PubMed Link] | [ Full text ]
Cahan, LD ; Geddes, JW ; Choi, BH ; Cotman, C. "Excitotoxic amino acid receptors in human complex partial epilepsy." Stereotactic and functional neurosurgery 54-55, (1990): 21-4. [PubMed Link] | [ Full text ]
Geddes, JW ; Hess, EJ ; Hart, RA ; Kesslak, JP ; Cotman, CW ; Wilson, MC "Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker." Neuroscience 38, 2 (1990): 515-25. [PubMed Link] | [ Full text ]
Geddes, JW ; Cotman, CW "Plasticity, pathology, and Alzheimer's disease." Neurobiology of aging 10, 5 (1989): 571-3; discussion 588-90. [PubMed Link] | [ Full text ]
Cotman, CW ; Geddes, JW ; Bridges, RJ ; Monaghan, DT "N-methyl-D-aspartate receptors and Alzheimer's disease." Neurobiology of aging 10, 5 (1989): 603-5; discussion 618-20. [PubMed Link] | [ Full text ]
Van Nostrand, WE ; Wagner, SL ; Suzuki, M.; Choi, BH ; Farrow, JS ; Geddes, JW ; Cotman, CW ; Cunningham, DD "Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor." Nature 341, 6242 (1989): 546-9. [PubMed Link] | [ Full text ]
Wagner, SL ; Geddes, JW ; Cotman, CW ; Lau, AL ; Gurwitz, D.; Isackson, PJ ; Cunningham, DD "Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease." Proceedings of the National Academy of Sciences of the United States of America 86, 21 (1989): 8284-8. [PubMed Link] | [ Full text ]
Geddes, JW ; Cooper, SM ; Cotman, CW ; Patel, S.; Meldrum, BS "N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio)." Neuroscience 32, 1 (1989): 39-47. [PubMed Link] | [ Full text ]
Monaghan, DT ; Geddes, JW ; Yao, D.; Chung, C ; Cotman, CW " 3H TCP binding sites in Alzheimer's disease." Neuroscience letters 73, 2 (1987): 197-200. [PubMed Link] | [ Full text ]
Geddes, JW ; Cotman, CW "Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease." Neuroscience research 3, 6 (1986): 672-8. [PubMed Link] | [ Full text ]
Geddes, JW ; Chang-Chui, H.; Cooper, SM ; Lott, IT ; Cotman, CW "Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease." Brain research 399, 1 (1986): 156-61. [PubMed Link] | [ Full text ]
Geddes, JW ; Anderson, KJ ; Cotman, CW "Senile plaques as aberrant sprout-stimulating structures." Experimental neurology 94, 3 (1986): 767-76. [PubMed Link] |
Wood, JD ; Kurylo, E.; Geddes, JW "Methionine-induced changes in glutamate, aspartate, glutamine, and gamma-aminobutyrate levels in brain tissue." Journal of neurochemistry 45, 3 (1985): 777-83. [PubMed Link] | [ Full text ]
Geddes, JW ; Monaghan, DT ; Cotman, CW ; Lott, IT ; Kim, RC ; Chui, HC "Plasticity of hippocampal circuitry in Alzheimer's disease." Science (New York, N.Y.) 230, 4730 (1985): 1179-81. [PubMed Link] | [ Full text ]
Geddes, JW ; Wood, JD "Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid." Journal of neurochemistry 42, 1 (1984): 16-24. [PubMed Link] | [ Full text ]
Wood, JD ; Geddes, JW ; Tsui, SK ; Kurylo, E. "Combined effects of a metabolic inhibitor (gabaculine) and an uptake inhibitor (ketamine) on the gamma-aminobutyrate system in mouse brain." Journal of neurochemistry 39, 6 (1982): 1710-5. [PubMed Link] | [ Full text ]
Geddes, JW ; Newstead, JD ; Wood, JD "Stability of the glutamate content of synaptosomes during their preparation." Neurochemical research 5, 10 (1980): 1107-16. [PubMed Link] |