James W Geddes, PhD

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Publications

Primary Contact: Jennifer Steinman
(859) 218-4093
MN 144 Willard Med Sci Bldg

Position(s):

Vice Dean for Research, College of Medicine

Professor, Dept. Neuroscience

Faculty, Spinal Cord and Brain Injury Research Center (SCoBIRC)

Affiliation(s):

Spinal Cord and Brain Injury Research Center

Neuroscience

Other Affiliation(s):

SCOBIRC - Core Faculty

Admin Personnel

PubMed Publications:

Ghoshal, S.;Bondada, V.;Saatman, K.E.;Guttmann, R.P.;Geddes, J.W. "Phage display for identification of serum biomarkers of traumatic brain injury." Journal of neuroscience methods 272, (2016): 33-37. [PubMed Link] | [ Full text ]
Schaefer, K.A.;Toral, M.A.;Velez, G.;Cox, A.J.;Baker, S.A.;Borcherding, N.C.;Colgan, D.F.;Bondada, V.;Mashburn, C.B.;Yu, C.G.;Geddes, J.W.;Tsang, S.H.;Bassuk, A.G.;Mahajan, V.B. "Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses." Investigative ophthalmology & visual science 57, 6 (2016): 2509-21. [PubMed Link] | [ Full text ]
Kulbe, J.R.;Geddes, J.W. "Current status of fluid biomarkers in mild traumatic brain injury." Experimental neurology 275 Pt 3, (2016): 334-352. [PubMed Link] | [ Full text ]
Meyer, C.A.;Singh, R.;Jones, M.T.;Yu, C.G.;Power, R.F.;Geddes, J.W. "Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression, but Does Not Improve Locomotor Function, following Spinal Cord Injury." PloS one 11, 1 (2016): e0147716. [PubMed Link] | [ Full text ]
Kim, D.Y.;Simeone, K.A.;Simeone, T.A.;Pandya, J.D.;Wilke, J.C.;Ahn, Y.;Geddes, J.W.;Sullivan, P.G.;Rho, J.M. "Ketone bodies mediate antiseizure effects through mitochondrial permeability transition." Annals of neurology 78, 1 (2015): 77-87. [PubMed Link] | [ Full text ]
Chotibut, T.;Davis, R.W.;Arnold, J.C.;Frenchek, Z.;Gurwara, S.;Bondada, V.;Geddes, J.W.;Salvatore, M.F. "Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model." Molecular neurobiology 49, 3 (2014): 1282-92. [PubMed Link] | [ Full text ]
Singh, R.;Brewer, M.K.;Mashburn, C.B.;Lou, D.;Bondada, V.;Graham, B.;Geddes, J.W. "Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies." The Journal of biological chemistry 289, 28 (2014): 19383-94. [PubMed Link] | [ Full text ]
Yu, C.G.;Singh, R.;Crowdus, C.;Raza, K.;Kincer, J.;Geddes, J.W. "Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury." Neuroscience 256, (2014): 163-9. [PubMed Link] | [ Full text ]
Yu, C.G.;Li, Y.;Raza, K.;Yu, X.X.;Ghoshal, S.;Geddes, J.W. "Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats." Journal of neurotrauma 30, 6 (2013): 427-33. [PubMed Link] | [ Full text ]
Bains, M.;Cebak, J.E.;Gilmer, L.K.;Barnes, C.C.;Thompson, S.N.;Geddes, J.W.;Hall, E.D. "Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model." Journal of neurochemistry 125, 1 (2013): 125-32. [PubMed Link] | [ Full text ]
Avery, M.A.;Rooney, T.M.;Pandya, J.D.;Wishart, T.M.;Gillingwater, T.H.;Geddes, J.W.;Sullivan, P.G.;Freeman, M.R. "WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering." Current biology : CB 22, 7 (2012): 596-600. [PubMed Link] | [ Full text ]
Blalock, E.M.;Buechel, H.M.;Popovic, J.;Geddes, J.W.;Landfield, P.W. "Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease." Journal of chemical neuroanatomy 42, 2 (2011): 118-26. [PubMed Link] | [ Full text ]
Naga, K.K.;Geddes, J.W. "Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release." Neuromolecular medicine 13, 1 (2011): 31-6. [PubMed Link] | [ Full text ]
Reneer, D.V.;Hisel, R.D.;Hoffman, J.M.;Kryscio, R.J.;Lusk, B.T.;Geddes, J.W. "A multi-mode shock tube for investigation of blast-induced traumatic brain injury." Journal of neurotrauma 28, 1 (2011): 95-104. [PubMed Link] | [ Full text ]
Cullen, D.K.;Xu, Y.;Reneer, D.V.;Browne, K.D.;Geddes, J.W.;Yang, S.;Smith, D.H. "Color changing photonic crystals detect blast exposure." NeuroImage 54 Suppl 1, (2011): S37-44. [PubMed Link] | [ Full text ]
Geddes, J.W.;Saatman, K.E. "Targeting individual calpain isoforms for neuroprotection." Experimental neurology 226, 1 (2010): 6-7. [PubMed Link] | [ Full text ]
Yu, C.G.;Yezierski, R.P.;Joshi, A.;Raza, K.;Li, Y.;Geddes, J.W. "Involvement of ERK2 in traumatic spinal cord injury." Journal of neurochemistry 113, 1 (2010): 131-42. [PubMed Link] | [ Full text ]
Nasr, P.;Carbery, T.;Geddes, J.W. "N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity." Neurochemical research 34, 3 (2009): 490-8. [PubMed Link] | [ Full text ]
Li, Y.;Bondada, V.;Joshi, A.;Geddes, J.W. "Calpain 1 and Calpastatin expression is developmentally regulated in rat brain." Experimental neurology 220, 2 (2009): 316-9. [PubMed Link] | [ Full text ]
Geddes, J.W.;Sullivan, P.G. "Special Issue: Mitochondria and neurodegeneration." Experimental neurology 218, 2 (2009): 169-70. [PubMed Link] | [ Full text ]
Joshi, A.;Bondada, V.;Geddes, J.W. "Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor." Experimental neurology 218, 2 (2009): 221-7. [PubMed Link] | [ Full text ]
Yu, C.G.;Joshi, A.;Geddes, J.W. "Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury." Journal of neurotrauma 25, 7 (2008): 833-40. [PubMed Link] | [ Full text ]
Badugu, R.;Garcia, M.;Bondada, V.;Joshi, A.;Geddes, J.W. "N terminus of calpain 1 is a mitochondrial targeting sequence." The Journal of biological chemistry 283, 6 (2008): 3409-17. [PubMed Link] | [ Full text ]
Zhang, S.X.;Holmberg, E.G.;Geddes, J.W. "Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde." Journal of neuroscience methods 163, 1 (2007): 38-43. [PubMed Link] | [ Full text ]
Naga, K.K.;Sullivan, P.G.;Geddes, J.W. "High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 28 (2007): 7469-75. [PubMed Link] | [ Full text ]
Yu, C.G.;Geddes, J.W. "Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury." Neurochemical research 32, 12 (2007): 2046-53. [PubMed Link] | [ Full text ]
Brown, M.R.;Sullivan, P.G.;Geddes, J.W. "Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria." The Journal of biological chemistry 281, 17 (2006): 11658-68. [PubMed Link] | [ Full text ]
Brown, M.R.;Bondada, V.;Keller, J.N.;Thorpe, J.;Geddes, J.W. "Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons." Journal of Alzheimer's disease : JAD 7, 1 (2005): 15-24. [PubMed Link] | [ Full text ]
Ravikumar, R.;Fugaccia, I.;Scheff, S.W.;Geddes, J.W.;Srinivasan, C.;Toborek, M. "Nicotine attenuates morphological deficits in a contusion model of spinal cord injury." Journal of neurotrauma 22, 2 (2005): 240-51. [PubMed Link] | [ Full text ]
Garcia, M.;Bondada, V.;Geddes, J.W. "Mitochondrial localization of mu-calpain." Biochemical and biophysical research communications 338, 2 (2005): 1241-7. [PubMed Link] | [ Full text ]
Geddes, J.W. "alpha-Synuclein: a potent inducer of tau pathology." Experimental neurology 192, 2 (2005): 244-50. [PubMed Link] | [ Full text ]
Zhang, S.X.;Geddes, J.W.;Owens, J.L.;Holmberg, E.G. "X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord." Histology and histopathology 20, 2 (2005): 519-30. [PubMed Link] | [ Full text ]
Ravikumar, R.;Flora, G.;Geddes, J.W.;Hennig, B.;Toborek, M. "Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma." Brain research. Molecular brain research 124, 2 (2004): 188-98. [PubMed Link] | [ Full text ]
Sengoku, T.;Bondada, V.;Hassane, D.;Dubal, S.;Geddes, J.W. "Tat-calpastatin fusion proteins transduce primary rat cortical neurons but do not inhibit cellular calpain activity." Experimental neurology 188, 1 (2004): 161-70. [PubMed Link] | [ Full text ]
Blalock, E.M.;Geddes, J.W.;Chen, K.C.;Porter, N.M.;Markesbery, W.R.;Landfield, P.W. "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses." Proceedings of the National Academy of Sciences of the United States of America 101, 7 (2004): 2173-8. [PubMed Link] | [ Full text ]
Brown, M.R.;Sullivan, P.G.;Dorenbos, K.A.;Modafferi, E.A.;Geddes, J.W.;Steward, O. "Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria." Journal of neuroscience methods 137, 2 (2004): 299-303. [PubMed Link] | [ Full text ]
Brown, M.R.;Geddes, J.W.;Sullivan, P.G. "Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium." Journal of bioenergetics and biomembranes 36, 4 (2004): 401-6. [PubMed Link] |
Pang, Z.;Bondada, V.;Sengoku, T.;Siman, R.;Geddes, J.W. "Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology." Journal of neuropathology and experimental neurology 62, 6 (2003): 633-43. [PubMed Link] |
Nasr, P.;Gursahani, H.I.;Pang, Z.;Bondada, V.;Lee, J.;Hadley, R.W.;Geddes, J.W. "Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid." Neurochemistry international 43, 2 (2003): 89-99. [PubMed Link] | [ Full text ]
Zhang, S.X.;Bondada, V.;Geddes, J.W. "Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection." Journal of neurotrauma 20, 1 (2003): 59-67. [PubMed Link] | [ Full text ]
Bu, J.;Bruckner, S.R.;Sengoku, T.;Geddes, J.W.;Estus, S. "Glutamate regulates caveolin expression in rat hippocampal neurons." Journal of neuroscience research 72, 2 (2003): 185-90. [PubMed Link] | [ Full text ]
LaFontaine, M.A.;Geddes, J.W.;Butterfield, D.A. "3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease." Neurochemical research 27, 6 (2002): 507-11. [PubMed Link] |
Aksenova, M.;Butterfield, D.A.;Zhang, S.X.;Underwood, M.;Geddes, J.W. "Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury." Journal of neurotrauma 19, 4 (2002): 491-502. [PubMed Link] | [ Full text ]
Aksenov, M.Y.;Aksenova, M.V.;Butterfield, D.A.;Geddes, J.W.;Markesbery, W.R. "Protein oxidation in the brain in Alzheimer's disease." Neuroscience 103, 2 (2001): 373-83. [PubMed Link] | [ Full text ]
Fontaine, M.A.;Geddes, J.W.;Banks, A.;Butterfield, D.A. "Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease." Journal of neurochemistry 75, 4 (2000): 1709-15. [PubMed Link] | [ Full text ]
LaFontaine, M.A.;Geddes, J.W.;Banks, A.;Butterfield, D.A. "3-nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease." Brain research 858, 2 (2000): 356-62. [PubMed Link] | [ Full text ]
Zhang, S.X.;Underwood, M.;Landfield, A.;Huang, F.F.;Gison, S.;Geddes, J.W. "Cytoskeletal disruption following contusion injury to the rat spinal cord." Journal of neuropathology and experimental neurology 59, 4 (2000): 287-96. [PubMed Link] |
Tekirian, T.L.;Yang, A.Y.;Glabe, C.;Geddes, J.W. "Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42." Journal of neurochemistry 73, 4 (1999): 1584-9. [PubMed Link] | [ Full text ]
Geddes, J.W.;Chang, N.G.;Ackley, D.C.;Soultanian, N.S.;McGillis, J.P.;Yokel, R.A. "Postmortem elevation in extracellular glutamate in the rat hippocampus when brain temperature is maintained at physiological levels: implications for the use of human brain autopsy tissues." Brain research 831, 1-2 (1999): 104-12. [PubMed Link] | [ Full text ]
Geddes, J.W.;Tekirian, T.L.;Mattson, M.P. "N-terminus truncated beta-amyloid peptides and C-terminus truncated secreted forms of amyloid precursor protein: distinct roles in the pathogenesis of Alzheimer's disease." Neurobiology of aging 20, 1 (1999): 75-9; discussion 87. [PubMed Link] | [ Full text ]
Bruce-Keller, A.J.;Geddes, J.W.;Knapp, P.E.;McFall, R.W.;Keller, J.N.;Holtsberg, F.W.;Parthasarathy, S.;Steiner, S.M.;Mattson, M.P. "Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD." Journal of neuroimmunology 93, 1-2 (1999): 53-71. [PubMed Link] | [ Full text ]
Endres, M.;Fink, K.;Zhu, J.;Stagliano, N.E.;Bondada, V.;Geddes, J.W.;Azuma, T.;Mattson, M.P.;Kwiatkowski, D.J.;Moskowitz, M.A. "Neuroprotective effects of gelsolin during murine stroke." The Journal of clinical investigation 103, 3 (1999): 347-54. [PubMed Link] | [ Full text ]
Maragos, W.F.;Jakel, R.J.;Chesnut, M.D.;Geddes, J.W.;Dwoskin, L.P. "Does dopamine contribute to striatal damage caused by impaired mitochondrial function?" Annals of the New York Academy of Sciences 893, (1999): 345-9. [PubMed Link] | [ Full text ]
Carman, H.M.;Dhillon, H.S.;Zhang, D.;Geddes, J.W.;Prasad, R.M. "Regional levels of phospholipase Cgamma after fluid percussion brain injury in the rat." Brain research 808, 1 (1998): 116-9. [PubMed Link] | [ Full text ]
Ashford, J.W.;Soultanian, N.S.;Zhang, S.X.;Geddes, J.W. "Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain." Journal of neuropathology and experimental neurology 57, 10 (1998): 972-8. [PubMed Link] |
Minger, S.L.;Geddes, J.W.;Holtz, M.L.;Craddock, S.D.;Whiteheart, S.W.;Siman, R.G.;Pettigrew, L.C. "Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia." Brain research 810, 1-2 (1998): 181-99. [PubMed Link] | [ Full text ]
Tekirian, T.L.;Saido, T.C.;Markesbery, W.R.;Russell, M.J.;Wekstein, D.R.;Patel, E.;Geddes, J.W. "N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits." Journal of neuropathology and experimental neurology 57, 1 (1998): 76-94. [PubMed Link] |
Maragos, W.F.;Jakel, R.J.;Pang, Z.;Geddes, J.W. "6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions." Experimental neurology 154, 2 (1998): 637-44. [PubMed Link] | [ Full text ]
Guo, Q.;Fu, W.;Xie, J.;Luo, H.;Sells, S.F.;Geddes, J.W.;Bondada, V.;Rangnekar, V.M.;Mattson, M.P. "Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease." Nature medicine 4, 8 (1998): 957-62. [PubMed Link] |
Springer, J.E.;Azbill, R.D.;Kennedy, S.E.;George, J.;Geddes, J.W. "Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment." Journal of neurochemistry 69, 4 (1997): 1592-600. [PubMed Link] | [ Full text ]
Geddes, J.W.;Panchalingam, K.;Keller, J.N.;Pettegrew, J.W. "Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions." Neurobiology of aging 18, 3 (1997): 305-8. [PubMed Link] | [ Full text ]
Pang, Z.;Geddes, J.W. "Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 9 (1997): 3064-73. [PubMed Link] | [ Full text ]
Geddes, J.W.;Tekirian, T.L.;Soultanian, N.S.;Ashford, J.W.;Davis, D.G.;Markesbery, W.R. "Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease." Neurobiology of aging 18, 4 Suppl (1997): S99-105. [PubMed Link] | [ Full text ]
Keller, J.N.;Pang, Z.;Geddes, J.W.;Begley, J.G.;Germeyer, A.;Waeg, G.;Mattson, M.P. "Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal." Journal of neurochemistry 69, 1 (1997): 273-84. [PubMed Link] | [ Full text ]
Mark, R.J.;Pang, Z.;Geddes, J.W.;Uchida, K.;Mattson, M.P. "Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 3 (1997): 1046-54. [PubMed Link] | [ Full text ]
Pettigrew, L.C.;Holtz, M.L.;Craddock, S.D.;Minger, S.L.;Hall, N.;Geddes, J.W. "Microtubular proteolysis in focal cerebral ischemia." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 16, 6 (1996): 1189-202. [PubMed Link] | [ Full text ]
Geddes, J.W.;Pang, Z.;Wiley, D.H. "Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease." Molecular and chemical neuropathology 28, 1-3 (1996): 65-74. [PubMed Link] |
Russell, M.J.;Bobik, M.;White, R.G.;Hou, Y.;Benjamin, S.A.;Geddes, J.W. "Age-specific onset of beta-amyloid in beagle brains." Neurobiology of aging 17, 2 (1996): 269-73. [PubMed Link] | [ Full text ]
Tekirian, T.L.;Cole, G.M.;Russell, M.J.;Yang, F.;Wekstein, D.R.;Patel, E.;Snowdon, D.A.;Markesbery, W.R.;Geddes, J.W. "Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains." Neurobiology of aging 17, 2 (1996): 249-57. [PubMed Link] | [ Full text ]
Geddes, J.W.;Pettigrew, L.C.;Holtz, M.L.;Craddock, S.D.;Maines, M.D. "Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain." Neuroscience letters 210, 3 (1996): 205-8. [PubMed Link] | [ Full text ]
Pang, Z.;Umberger, G.H.;Geddes, J.W. "Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801." Journal of neurochemistry 66, 2 (1996): 474-84. [PubMed Link] | [ Full text ]
Mattson, M.P.;Cheng, B.;Baldwin, S.A.;Smith-Swintosky, V.L.;Keller, J.;Geddes, J.W.;Scheff, S.W.;Christakos, S. "Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response." Journal of neuroscience research 42, 3 (1995): 357-70. [PubMed Link] | [ Full text ]
Geddes, J.W.;Bondada, V.;Tekirian, T.L.;Pang, Z.;Siman, R.G. "Perikaryal accumulation and proteolysis of neurofilament proteins in the post-mortem rat brain." Neurobiology of aging 16, 4 (1995): 651-60. [PubMed Link] | [ Full text ]
Geddes, J.W.;Schwab, C.;Craddock, S.;Wilson, J.L.;Pettigrew, L.C. "Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 14, 4 (1994): 554-64. [PubMed Link] | [ Full text ]
Geddes, J.W.;Bondada, V.;Keller, J.N. "Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2." Brain research 633, 1-2 (1994): 1-8. [PubMed Link] | [ Full text ]
Schwab, C.;Bondada, V.;Sparks, D.L.;Cahan, L.D.;Geddes, J.W. "Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus." Hippocampus 4, 2 (1994): 210-25. [PubMed Link] | [ Full text ]
Geddes, J.W.;Ułas, J.;Brunner, L.C.;Choe, W.;Cotman, C.W. "Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors." Neuroscience 50, 1 (1992): 23-34. [PubMed Link] | [ Full text ]
Cummings, B.J.;Su, J.H.;Geddes, J.W.;Van Nostrand, W.E.;Wagner, S.L.;Cunningham, D.D.;Cotman, C.W. "Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease." Neuroscience 48, 4 (1992): 763-77. [PubMed Link] | [ Full text ]
Ułas, J.;Brunner, L.C.;Geddes, J.W.;Choe, W.;Cotman, C.W. "N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease." Neuroscience 49, 1 (1992): 45-61. [PubMed Link] | [ Full text ]
Geddes, J.W.;Brunner, L.;Cotman, C.W.;Buzsáki, G. "Alterations in 3H kainate and N-methyl-D-aspartate-sensitive L- 3H -glutamate binding in the rat hippocampal formation following fimbria-fornix lesions." Experimental neurology 115, 2 (1992): 271-81. [PubMed Link] | [ Full text ]
Russell, M.J.;White, R.;Patel, E.;Markesbery, W.R.;Watson, C.R.;Geddes, J.W. "Familial influence on plaque formation in the beagle brain." Neuroreport 3, 12 (1992): 1093-6. [PubMed Link] |
Geddes, J.W.;Lundgren, K.;Kim, Y.K. "Aberrant localization of MAP5 immunoreactivity in the hippocampal formation in Alzheimer's disease." Journal of neuroscience research 30, 1 (1991): 183-91. [PubMed Link] | [ Full text ]
Geddes, J.W.;Cotman, C.W. "Plasticity in Alzheimer's disease: too much or not enough?" Neurobiology of aging 12, 4 (1991): 330-3; discussion 352-5. [PubMed Link] | [ Full text ]
Johnson, B.A.;Shirokawa, J.M.;Geddes, J.W.;Choi, B.H.;Kim, R.C.;Aswad, D.W. "Protein L-isoaspartyl methyltransferase in postmortem brains of aged humans." Neurobiology of aging 12, 1 (1991): 19-24. [PubMed Link] | [ Full text ]
Vijayan, V.K.;Geddes, J.W.;Anderson, K.J.;Chang-Chui, H.;Ellis, W.G.;Cotman, C.W. "Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation." Experimental neurology 112, 1 (1991): 72-8. [PubMed Link] |
Russell, M.J.;Vijayan, V.K.;Gibbs, R.B.;Geddes, J.W.;Jacobson, C.H.;Cotman, C.W. "Long-term survival of neural transplants to senescence in rats." Experimental neurology 108, 2 (1990): 105-8. [PubMed Link] | [ Full text ]
Geddes, J.W.;Cahan, L.D.;Cooper, S.M.;Kim, R.C.;Choi, B.H.;Cotman, C.W. "Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy." Experimental neurology 108, 3 (1990): 214-20. [PubMed Link] |
Geddes, J.W.;Wong, J.;Choi, B.H.;Kim, R.C.;Cotman, C.W.;Miller, F.D. "Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease." Neuroscience letters 109, 1-2 (1990): 54-61. [PubMed Link] | [ Full text ]
Cotman, C.W.;Geddes, J.W.;Kahle, J.S. "Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?" Progress in brain research 83, (1990): 427-34. [PubMed Link] |
Miller, F.D.;Geddes, J.W. "Increased expression of the major embryonic alpha-tubulin mRNA, T alpha 1, during neuronal regeneration, sprouting, and in Alzheimer's disease." Progress in brain research 86, (1990): 321-30. [PubMed Link] |
Geddes, J.W.;Wilson, M.C.;Miller, F.D.;Cotman, C.W. "Molecular markers of reactive plasticity." Advances in experimental medicine and biology 268, (1990): 425-32. [PubMed Link] |
Cotman, C.W.;Geddes, J.W.;Ulas, J.;Klein, M. "Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease." Progress in brain research 86, (1990): 55-61. [PubMed Link] |
Cahan, L.D.;Geddes, J.W.;Choi, B.H.;Cotman, C. "Excitotoxic amino acid receptors in human complex partial epilepsy." Stereotactic and functional neurosurgery 54-55, (1990): 21-4. [PubMed Link] | [ Full text ]
Geddes, J.W.;Hess, E.J.;Hart, R.A.;Kesslak, J.P.;Cotman, C.W.;Wilson, M.C. "Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker." Neuroscience 38, 2 (1990): 515-25. [PubMed Link] | [ Full text ]
Geddes, J.W.;Cotman, C.W. "Plasticity, pathology, and Alzheimer's disease." Neurobiology of aging 10, 5 (1989): 571-3; discussion 588-90. [PubMed Link] | [ Full text ]
Cotman, C.W.;Geddes, J.W.;Bridges, R.J.;Monaghan, D.T. "N-methyl-D-aspartate receptors and Alzheimer's disease." Neurobiology of aging 10, 5 (1989): 603-5; discussion 618-20. [PubMed Link] | [ Full text ]
Van Nostrand, W.E.;Wagner, S.L.;Suzuki, M.;Choi, B.H.;Farrow, J.S.;Geddes, J.W.;Cotman, C.W.;Cunningham, D.D. "Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor." Nature 341, 6242 (1989): 546-9. [PubMed Link] | [ Full text ]
Wagner, S.L.;Geddes, J.W.;Cotman, C.W.;Lau, A.L.;Gurwitz, D.;Isackson, P.J.;Cunningham, D.D. "Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease." Proceedings of the National Academy of Sciences of the United States of America 86, 21 (1989): 8284-8. [PubMed Link] | [ Full text ]
Geddes, J.W.;Cooper, S.M.;Cotman, C.W.;Patel, S.;Meldrum, B.S. "N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio)." Neuroscience 32, 1 (1989): 39-47. [PubMed Link] | [ Full text ]
Monaghan, D.T.;Geddes, J.W.;Yao, D.;Hung, C.C.;Cotman, C.W. " 3H TCP binding sites in Alzheimer's disease." Neuroscience letters 73, 2 (1987): 197-200. [PubMed Link] | [ Full text ]
Geddes, J.W.;Cotman, C.W. "Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease." Neuroscience research 3, 6 (1986): 672-8. [PubMed Link] | [ Full text ]
Geddes, J.W.;Chang-Chui, H.;Cooper, S.M.;Lott, I.T.;Cotman, C.W. "Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease." Brain research 399, 1 (1986): 156-61. [PubMed Link] | [ Full text ]
Geddes, J.W.;Anderson, K.J.;Cotman, C.W. "Senile plaques as aberrant sprout-stimulating structures." Experimental neurology 94, 3 (1986): 767-76. [PubMed Link] |
Wood, J.D.;Kurylo, E.;Geddes, J.W. "Methionine-induced changes in glutamate, aspartate, glutamine, and gamma-aminobutyrate levels in brain tissue." Journal of neurochemistry 45, 3 (1985): 777-83. [PubMed Link] | [ Full text ]
Geddes, J.W.;Monaghan, D.T.;Cotman, C.W.;Lott, I.T.;Kim, R.C.;Chui, H.C. "Plasticity of hippocampal circuitry in Alzheimer's disease." Science (New York, N.Y.) 230, 4730 (1985): 1179-81. [PubMed Link] | [ Full text ]
Geddes, J.W.;Wood, J.D. "Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid." Journal of neurochemistry 42, 1 (1984): 16-24. [PubMed Link] | [ Full text ]
Wood, J.D.;Geddes, J.W.;Tsui, S.K.;Kurylo, E. "Combined effects of a metabolic inhibitor (gabaculine) and an uptake inhibitor (ketamine) on the gamma-aminobutyrate system in mouse brain." Journal of neurochemistry 39, 6 (1982): 1710-5. [PubMed Link] | [ Full text ]
Geddes, J.W.;Newstead, J.D.;Wood, J.D. "Stability of the glutamate content of synaptosomes during their preparation." Neurochemical research 5, 10 (1980): 1107-16. [PubMed Link] |