Qingding Wang, MD

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About
Education
Publications

qingding.wang@uky.edu
859-323-4282

Position(s):

Associate Professor

Affiliation(s):

Surgery

Other Affiliation(s):

Surgery/General

Research

Interests / Specialties:

Human intestinal cell differentiation

Bio / Education:

Medical School (MD)
Lanzhou Medical College, Lanzhou, China

Pharmacology Research (MS)
Lanzhou Medical College, Lanzhou, China

Biochemical Pharmacology Research (PhD)
Institute of Beijing – Pharmacology and Toxicology, Beijing, China

PubMed Publications:

Wang, Q.;Zhou, Y.;Rychahou, P.;Harris, J.W.;Zaytseva, Y.Y.;Liu, J.;Wang, C.;Weiss, H.L.;Liu, C.;Lee, E.Y.;Evers, B.M. "Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth." Cancer research 78, 12 (2018): 3163-3175. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Rychahou, P.;Fan, T.W.;Lane, A.N.;Weiss, H.L.;Evers, B.M. "Ketogenesis contributes to intestinal cell differentiation." Cell death and differentiation 24, 3 (2017): 458-468. [PubMed Link] | [ Full text ]
Zhou, Y.;Rychahou, P.;Wang, Q.;Weiss, H.L.;Evers, B.M. "TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium." Cell death & disease 6, (2015): e1631. [PubMed Link] | [ Full text ]
Zhou, Y.;Wang, Q.;Weiss, H.L.;Evers, B.M. "Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway." Molecular biology of the cell 25, 18 (2014): 2882-90. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Rychahou, P.;Liu, C.;Weiss, H.L.;Evers, B.M. "NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation." Cell death & disease 4, (2013): e671. [PubMed Link] | [ Full text ]
Guo, Z.;Zhou, Y.;Evers, B.M.;Wang, Q. "Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells." Biochemical and biophysical research communications 418, 2 (2012): 426-32. [PubMed Link] | [ Full text ]
Zhou, Y.;Wang, Q.;Guo, Z.;Weiss, H.L.;Evers, B.M. "Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells." Molecular biology of the cell 23, 15 (2012): 2963-72. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Jackson, L.N.;Johnson, S.M.;Chow, C.W.;Evers, B.M. "Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation." Molecular biology of the cell 22, 3 (2011): 412-20. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Weiss, H.L.;Chow, C.W.;Evers, B.M. "NFATc1 regulation of TRAIL expression in human intestinal cells." PloS one 6, 5 (2011): e19882. [PubMed Link] | [ Full text ]
Wang, X.;Jackson, L.N.;Johnson, S.M.;Wang, Q.;Evers, B.M. "Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers." Molecular cancer therapeutics 9, 8 (2010): 2389-98. [PubMed Link] | [ Full text ]
Bowen, K.A.;Doan, H.Q.;Zhou, B.P.;Wang, Q.;Zhou, Y.;Rychahou, P.G.;Evers, B.M. "PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells." Anticancer research 29, 11 (2009): 4439-49. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Wang, X.;Evers, B.M. "p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells." Cell death and differentiation 15, 5 (2008): 908-19. [PubMed Link] | [ Full text ]
Jackson, L.N.;Zhou, Y.;Qiu, S.;Wang, Q.;Evers, B.M. "Alternative medicine products as a novel treatment strategy for inflammatory bowel disease." The American journal of Chinese medicine 36, 5 (2008): 953-65. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Wang, X.;Chung, D.H.;Evers, B.M. "Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition." Cancer research 67, 16 (2007): 7773-81. [PubMed Link] | [ Full text ]
Wang, X.;Wang, Q.;Ives, K.L.;Evers, B.M. "Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells." Clinical cancer research : an official journal of the American Association for Cancer Research 12, 18 (2006): 5346-55. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Evers, B.M. "Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells." Neoplasia (New York, N.Y.) 8, 9 (2006): 781-7. [PubMed Link] |
Wang, Q.;Zhou, Y.;Wang, X.;Evers, B.M. "Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase." Oncogene 25, 1 (2006): 43-50. [PubMed Link] | [ Full text ]
Wang, Q.;Wang, X.;Zhou, Y.;Evers, B.M. "PKCdelta-mediated regulation of FLIP expression in human colon cancer cells." International journal of cancer 118, 2 (2006): 326-34. [PubMed Link] | [ Full text ]
Li, N.;Wang, Q.;Li, J.;Wang, X.;Hellmich, M.R.;Rajaraman, S.;Greeley GH, J.;Townsend CM, J.;Evers, B.M. "Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON." American journal of physiology. Gastrointestinal and liver physiology 288, 2 (2005): G213-20. [PubMed Link] | [ Full text ]
Zhou, Y.;Wang, Q.;Evers, B.M.;Chung, D.H. "Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis." Pediatric research 58, 6 (2005): 1192-7. [PubMed Link] | [ Full text ]
Wang, X.;Wang, Q.;Hu, W.;Evers, B.M. "Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway." Oncogene 23, 10 (2004): 1885-95. [PubMed Link] | [ Full text ]
Wang, Q.;Wang, X.;Evers, B.M. "Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B." The Journal of biological chemistry 278, 51 (2003): 51091-9. [PubMed Link] | [ Full text ]
Wang, Q.;Wang, X.;Hernandez, A.;Hellmich, M.R.;Gatalica, Z.;Evers, B.M. "Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells." The Journal of biological chemistry 277, 39 (2002): 36602-10. [PubMed Link] | [ Full text ]
Kim, S.;Domon-Dell, C.;Wang, Q.;Chung, D.H.;Di Cristofano, A.;Pandolfi, P.P.;Freund, J.N.;Evers, B.M. "PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway." Gastroenterology 123, 4 (2002): 1163-78. [PubMed Link] | [ Full text ]
Wang, Q.;Li, N.;Wang, X.;Kim, M.M.;Evers, B.M. "Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line." Clinical cancer research : an official journal of the American Association for Cancer Research 8, 6 (2002): 1940-7. [PubMed Link] | [ Full text ]
Domon-Dell, C.;Wang, Q.;Kim, S.;Kedinger, M.;Evers, B.M.;Freund, J.N. "Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells." Gut 50, 4 (2002): 525-9. [PubMed Link] | [ Full text ]
Wang, Q.;Wang, X.;Hernandez, A.;Kim, S.;Evers, B.M. "Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation." Gastroenterology 120, 6 (2001): 1381-92. [PubMed Link] | [ Full text ]
Ding, Q.;Wang, Q.;Evers, B.M. "Alterations of MAPK activities associated with intestinal cell differentiation." Biochemical and biophysical research communications 284, 2 (2001): 282-8. [PubMed Link] | [ Full text ]
Hernandez, A.;Wang, Q.D.;Schwartz, S.A.;Evers, B.M. "Sensitization of human colon cancer cells to TRAIL-mediated apoptosis." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 5, 1 (2001): 56-65. [PubMed Link] |
Wang, Q.;Ji, Y.;Wang, X.;Evers, B.M. "Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene." Biochemical and biophysical research communications 276, 2 (2000): 466-71. [PubMed Link] | [ Full text ]
Hernandez, A.;Smith, F.;Wang, Q.;Wang, X.;Evers, B.M. "Assessment of differential gene expression patterns in human colon cancers." Annals of surgery 232, 4 (2000): 576-85. [PubMed Link] | [ Full text ]
Wang, Q.;Kim, S.;Wang, X.;Evers, B.M. "Activation of NF-kappaB binding in HT-29 colon cancer cells by inhibition of phosphatidylinositol 3-kinase." Biochemical and biophysical research communications 273, 3 (2000): 853-8. [PubMed Link] | [ Full text ]
Wang, Q.;Ding, Q.;Dong, Z.;Ehlers, R.A.;Evers, B.M. "Downregulation of mitogen-activated protein kinases in human colon cancers." Anticancer research 20, 1A (2000): 75-83. [PubMed Link] |
Ding, Q.;Wang, Q.;Dong, Z.;Evers, B.M. "Characterization and regulation of E2F activity during Caco-2 cell differentiation." American journal of physiology. Cell physiology 278, 1 (2000): C110-7. [PubMed Link] | [ Full text ]