Steven Shedlofsky, M.D.

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shedlof@email.uky.edu

Clinic : (859) 323-0079; Academic Office:(859) 323-4937

MN649 WM R WILLARD MED ED BLDG

Position(s):

Professor

Affiliation(s):

Internal Medicine

Other Affiliation(s):

Internal Medicine - Digestive Health

Toxicology - Joint Faculty

Bio / Education:

University of Michigan, Ann Arbor, MI	MD	1974	Medicine
Hospital of the University of Pennsylvania, Philadelphia, PA	Intern	1975	Internal Medicine
Hospital of the University of Pennsylvania, Philadelphia, PA	Residency	1977	Internal Medicine
Washington University School of Medicine, St. Louis, MO	Fellowship	1980	Gastroenterology

PubMed Publications:

Balwani, M ; Sardh, E ; Ventura, P ; Peiró, PA ; Rees, DC ; Stölzel, U ; Bissell, DM ; Bonkovsky, HL ; Windyga, J ; Anderson, KE ; Parker, C.; Silver, SM ; Keel, SB ; Wang, JD ; Stein, PE ; Harper, P ; Vassiliou, D ; Wang, B.; Phillips, J.; Ivanova, A ; Langendonk, JG ; Kauppinen, R ; Minder, E ; Horie, Y.; Penz, C ; Chen, J.; Liu, S.; Ko, JJ ; Sweetser, MT ; Garg, P.; Vaishnaw, A ; Kim, JB ; Simon, AR ; Gouya, L ; ENVISION, Investigators. "Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria." The New England journal of medicine 382, 24 (2020): 2289-2301. [PubMed Link] | [ Full text ]
Momah, N.; Otesile, A.; Pawa, R.; Shedlofsky, S. "Sarcoidosis Presenting as Necrotizing Sarcoid Granulomatosis of the Liver, Sclerosing Cholangitis, and Gastric Ulcer." ACG case reports journal 1, 3 (2014): 164-6. [PubMed Link] | [ Full text ]
Anderson, KE ; Bonkovsky, HL ; Bloomer, JR ; Shedlofsky, SI "Reconstitution of hematin for intravenous infusion." Annals of internal medicine 144, 7 (2006): 537-8. [PubMed Link] | [ Full text ]
Shedlofsky, SI "Does iron reduction improve sustained viral responses to interferon monotherapy in hepatitis C patients? Maybe, but is this the right question?" The American journal of gastroenterology 97, 5 (2002): 1093-6. [PubMed Link] | [ Full text ]
Roe, AL ; Poloyac, SM ; Howard, G.; Shedlofsky, SI ; Blouin, RA "The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat." The Journal of pharmacy and pharmacology 53, 10 (2001): 1365-71. [PubMed Link] | [ Full text ]
Shedlofsky, SI ; Tosheva, RT ; Snawder, JA "Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B." Biochemical pharmacology 59, 10 (2000): 1295-303. [PubMed Link] | [ Full text ]
Poloyac, SM ; Tosheva, RT ; Gardner, BM ; Shedlofsky, SI ; Blouin, RA "The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans." Clinical pharmacology and therapeutics 66, 6 (1999): 554-62. [PubMed Link] | [ Full text ]
Shedlofsky, SI "Role of iron in the natural history and clinical course of hepatitis C disease." Hepato-gastroenterology 45, 20 (1998): 349-55. [PubMed Link] |
Shedlofsky, SI ; Israel, BC ; Tosheva, R.; Blouin, RA "Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women." British journal of clinical pharmacology 43, 6 (1997): 627-32. [PubMed Link] | [ Full text ]
Sinclair, PR ; Gorman, N.; Shedlofsky, SI ; Honsinger, CP ; Sinclair, JF ; Karagas, MR ; Anderson, KE "Ascorbic acid deficiency in porphyria cutanea tarda." The Journal of laboratory and clinical medicine 130, 2 (1997): 197-201. [PubMed Link] | [ Full text ]
Shedlofsky, SI ; Israel, BC ; McClain, CJ ; Hill, DB ; Blouin, RA "Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism." The Journal of clinical investigation 94, 6 (1994): 2209-14. [PubMed Link] | [ Full text ]
McClain, CJ ; Cohen, DA ; Dinarello, CA ; Cannon, JG ; Shedlofsky, SI ; Kaplan, AM "Serum interleukin-1 (IL-1) activity in alcoholic hepatitis." Life sciences 39, 16 (1986): 1479-85. [PubMed Link] | [ Full text ]