Qing-Bai She, Ph.D.

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qing-bai.she@uky.edu

859-323-2851

Todd Bldg. 555

Position(s):

Professor

Department of Pharmacology & Nutritional Sciences

Markey Cancer Center

Affiliation(s):

Pharmacology & Nutritional Sciences

Other Affiliation(s):

Markey Cancer Center - Affiliated Faculty

Pharmacology and Nutritional Sciences Center Affiliated Faculty

Nutritional Sciences Graduate Faculty

Department of Toxicology and Cancer Biology

Interests / Specialties:

Translational control in cancer progression and metastasis; drug resistance and cancer therapeutics

Bio / Education:

Ph.D., Gifu University
Postdoctoral Fellow, University of Minnesota
Senior Research Scientist, Memorial Sloan-Kettering Cancer Center

Research Description:

Research in my lab focuses on identification and characterization of oncogenic factors and pathways that drive disease progression and therapeutic resistance in colorectal cancer (CRC). We particularly study the mechanistic basis of redundancy and crosstalk among oncoprotein-activated signaling pathways and how the functional crosstalk among these pathways promotes cancer progression and alters the therapeutic response to CRC. We employ a combination of molecular, cellular, biochemical, genetic, pharmacologic, imaging, bioinformatic, animal and clinical association approaches to decipher the transcriptional and post-transcriptional mechanisms controlling gene expression and pathways important for the malignant transformation and metastatic progression of CRC, with the ultimate goal of developing novel biomarkers and therapies for improving the diagnosis and treatment of this disease. Through molecular analysis of mRNA translation states, our work establishes dysregulation of cap-dependent translation downstream of mTOR at the level of 4E-BP1/eIF4E, as a key to tumor formation, metastasis and resistance to upstream kinase-targeted therapies. Specifically, we identify 4E-BP1 as a critical node that integrates the oncogenic effects of the PI3K/AKT and RAS/RAF/MEK/ERK pathways in CRC progression. In addition, we discover several natural product-based small molecular inhibitors with a novel mechanism of action in targeting translational control of CRC and potentially other major cancers. Moreover, our recent work uncovers 1) two novel neuropilin-1 (NRP1) splice variants that can promote CRC metastasis by activating endosomal signals, and 2) a novel function of spemine synthase (SMS), a polyamine biosynthetic enzyme, in cooperation with MYC oncogene to maintain CRC tumorigenesis by convergent repression of Bim expression. The key insights of the NRP1 variants and SMS function in reprograming of polyamine metabolism in cancers as well as their modulations of therapeutic outcomes are further characterizing in the lab.

Grants:

Active
NIH R01CA175105
NIH R01CA203257
NIH R21ES031712

Completed
1. ACS IRG85-001-22
2. UK CCTS KL2TR000116

Selected Publications:

1. Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zaytseva YY, Schwartz CE, Lee EY, Evers BM, Morris AJ, Liu S, She QB. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by convergent repression of Bim expression. Nat Commun, 11:3243, 2020. PMCID: PMC7320137
2. Huang X, Ye Q, Chen M, Li A, Mi W, Fang Y, Zaytseva YY, O’Connor KL, Vander Kooi CW, Liu S, She QB. N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Nat Commun, 10:3708, 2019. PMCID: PMC6697747 (selected by Faculty 1000 rated exceptional)
3. Zhang Y, Ye Q, Ponomareva LV, Liu Y, Cao Y, Cui Z, Van Lanen, SG, Voss SR, She QB*, Thorson JS*. Total synthesis of griseusins and elucidation of the griseusin mechanism of action. Chem Sci, 10:7641-7648, 2019. PMCID: PMC6755659 (Edge Article; *Co-corresponding author)
4. Ye Q, Zhang Y, Cao Y, Wang X, Guo Y, Chen J, Horn J, Ponomareva LV, Chaiswing L, Shaaban KA, Wei Q, Anderson BD, St Clair KD, Zhu H, Leggas M, Thorson JS, She QB. Frenolicin B targets peroxiredoxin 1 and glutaredoxin 3 to trigger ROS/4E-BP1-mediated antitumor effects. Cell Chem Biol 26:366-377, 2019. PMCID: PMC6557261. (Featured Article)
5. Wang J, Ye Q, Cao Y, Guo Y, Huang X, Mi W, Liu S, Wang C, Yang HS, Zhou BP, Evers BM, She QB. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun 8:2207, 2017. PMCID: PMC5738350
6. Mi W, Ye Q, Liu S, She QB. AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis. Oncotarget 6:13962-13977, 2015. PMCID: PMC4546444. (Priority Research Paper)
7. Cai W, Ye Q, She QB. Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via translational activation of snail. Oncotarget 5:6015-6027, 2014. PMCID: PMC4171609
8. Ye Q, Cai W, Zhen Y, Evers BM, She QB. ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Oncogene 33:1828-1839, 2014. PMCID: PMC3966979
9. She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, Solit, DB, Rosen N. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell 18:39-51, 2010. PMCID: PMC3286650
10. Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Res 70:6804-6814, 2010.
11. She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS ONE 3:e3065, 2010.
12. Rosen N, She QB. AKT and cancer--is it all mTOR? Cancer Cell 10:254-256, 2006.
13. She, QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 8:287-297, 2005.
14. She QB, Solit D, Basso A, Moasser MM. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling. Clin Cancer Res 9:4340-4346, 2003.

https://www.ncbi.nlm.nih.gov/myncbi/qing-bai.she.1/bibliography/public/
https://scholar.google.com/citations?user=_Wyw_d8AAAAJ&hl=en&oi=ao

PubMed Publications:

Guo, Y.; Ye, Q.; Deng, P.; Cao, Y.; He, D.; Zhou, Z.; Wang, C.; Zaytseva, YY ; Schwartz, CE ; Lee, EY ; Mark Evers, B.; Morris, AJ ; Liu, S.; She, QB "Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression." Nature communications 11, 1 (2020): 3243. [PubMed Link] | [ Full text ]
Ye, Q.; Zhang, Y.; Cao, Y.; Wang, X.; Guo, Y.; Chen, J.; Horn, J.; Ponomareva, LV ; Chaiswing, L.; Shaaban, KA ; Wei, Q.; Anderson, BD ; St Clair, DK ; Zhu, H.; Leggas, M.; Thorson, JS ; She, QB "Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects." Cell chemical biology 26, 3 (2019): 366-377.e12. [PubMed Link] | [ Full text ]
Wang, X.; Elshahawi, SI ; Ponomareva, LV ; Ye, Q.; Liu, Y.; Copley, GC ; Hower, JC ; Hatcher, BE ; Kharel, MK ; Van Lanen, SG ; She, QB ; Voss, SR ; Thorson, JS ; Shaaban, KA "Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated <i>Streptomyces</i>." Journal of natural products 82, 12 (2019): 3469-3476. [PubMed Link] | [ Full text ]
Zhang, Y.; Ye, Q.; Ponomareva, LV ; Cao, Y.; Liu, Y.; Cui, Z.; Van Lanen, SG ; Voss, SR ; She, QB ; Thorson, JS "Total synthesis of griseusins and elucidation of the griseusin mechanism of action." Chemical science 10, 32 (2019): 7641-7648. [PubMed Link] | [ Full text ]
Huang, X.; Ye, Q.; Chen, M.; Li, A.; Mi, W.; Fang, Y.; Zaytseva, YY ; O'Connor, KL ; Vander Kooi, CW ; Liu, S.; She, QB "N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals." Nature communications 10, 1 (2019): 3708. [PubMed Link] | [ Full text ]
Goretsky, T.; Bradford, EM ; Ye, Q.; Lamping, OF ; Vanagunas, T.; Moyer, MP ; Keller, PC ; Sinh, P.; Llovet, JM ; Gao, T.; She, QB ; Li, L.; Barrett, TA "Beta-catenin cleavage enhances transcriptional activation." Scientific reports 8, 1 (2018): 671. [PubMed Link] | [ Full text ]
Wang, J.; Ye, Q.; Cao, Y.; Guo, Y.; Huang, X.; Mi, W.; Liu, S.; Wang, C.; Yang, HS ; Zhou, BP ; Evers, BM ; She, QB "Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1." Nature communications 8, 1 (2017): 2207. [PubMed Link] | [ Full text ]
She, QB ; Gruvberger-Saal, SK ; Maurer, M.; Chen, Y.; Jumppanen, M.; Su, T.; Dendy, M.; Lau, YK ; Memeo, L.; Horlings, HM ; Vijver, MJ ; Isola, J.; Hibshoosh, H.; Rosen, N.; Parsons, R.; Saal, LH "Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer." BMC cancer 16, (2016): 587. [PubMed Link] | [ Full text ]
Zhang, Y.; Ye, Q.; Wang, X.; She, QB ; Thorson, JS "A divergent enantioselective strategy for the synthesis of griseusins." Angewandte Chemie (International ed. in English) 54, 38 (2015): 11219-22. [PubMed Link] | [ Full text ]
Mi, W.; Ye, Q.; Liu, S.; She, QB "AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis." Oncotarget 6, 16 (2015): 13962-77. [PubMed Link] | [ Full text ]
She, QB "4E-BP1 as an oncotarget." Aging 7, 8 (2015): 517-8. [PubMed Link] | [ Full text ]
Nandurkar, NS ; Zhang, J.; Ye, Q.; Ponomareva, LV ; She, QB ; Thorson, JS "The identification of perillyl alcohol glycosides with improved antiproliferative activity." Journal of medicinal chemistry 57, 17 (2014): 7478-84. [PubMed Link] | [ Full text ]
Baldwin, LA ; Hoff, JT ; Lefringhouse, J.; Zhang, M.; Jia, C.; Liu, Z.; Erfani, S.; Jin, H.; Xu, M.; She, QB ; Van Nagell, JR ; Wang, C.; Chen, L.; Plattner, R.; Kaetzel, DM ; Luo, J.; Lu, M.; West, D.; Liu, C.; Ueland, FR ; Drapkin, R.; Zhou, BP ; Yang, XH "CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling." Oncotarget 5, 23 (2014): 12203-17. [PubMed Link] | [ Full text ]
Cai, W.; Ye, Q.; She, QB "Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail." Oncotarget 5, 15 (2014): 6015-27. [PubMed Link] | [ Full text ]
Ye, Q.; Cai, W.; Zheng, Y.; Evers, BM ; She, QB "ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer." Oncogene 33, 14 (2014): 1828-39. [PubMed Link] | [ Full text ]
Wang, J.; Ye, Q.; She, QB "New insights into 4E-BP1-regulated translation in cancer progression and metastasis." Cancer cell & microenvironment 1, 5 (2014): [PubMed Link] |
Zhang, Y.; Wang, X.; Sunkara, M.; Ye, Q.; Ponomereva, LV ; She, QB ; Morris, AJ ; Thorson, JS "A diastereoselective oxa-Pictet-Spengler-based strategy for (+)-frenolicin B and epi-(+)-frenolicin B synthesis." Organic letters 15, 21 (2013): 5566-9. [PubMed Link] | [ Full text ]
Liu, Y.; Liu, F.; Yu, H.; Zhao, X.; Sashida, G.; Deblasio, A.; Harr, M.; She, QB ; Chen, Z.; Lin, HK ; Di Giandomenico, S.; Elf, SE ; Yang, Y.; Miyata, Y.; Huang, G.; Menendez, S.; Mellinghoff, IK ; Rosen, N.; Pandolfi, PP ; Hedvat, CV ; Nimer, SD "Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus." Science signaling 5, 247 (2012): ra77. [PubMed Link] | [ Full text ]
Xing, F.; Persaud, Y.; Pratilas, CA ; Taylor, BS ; Janakiraman, M.; She, QB ; Gallardo, H.; Liu, C.; Merghoub, T.; Hefter, B.; Dolgalev, I.; Viale, A.; Heguy, A.; De Stanchina, E.; Cobrinik, D.; Bollag, G.; Wolchok, J.; Houghton, A.; Solit, DB "Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF." Oncogene 31, 4 (2012): 446-57. [PubMed Link] | [ Full text ]
Hanrahan, AJ ; Schultz, N.; Westfal, ML ; Sakr, RA ; Giri, DD ; Scarperi, S.; Janakiraman, M.; Olvera, N.; Stevens, EV ; She, QB ; Aghajanian, C.; King, TA ; Stanchina, Ed ; Spriggs, DR ; Heguy, A.; Taylor, BS ; Sander, C.; Rosen, N.; Levine, DA ; Solit, DB "Genomic complexity and AKT dependence in serous ovarian cancer." Cancer discovery 2, 1 (2012): 56-67. [PubMed Link] | [ Full text ]
Halilovic, E.; She, QB ; Ye, Q.; Pagliarini, R.; Sellers, WR ; Solit, DB ; Rosen, N. "PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling." Cancer research 70, 17 (2010): 6804-14. [PubMed Link] | [ Full text ]
She, QB ; Halilovic, E.; Ye, Q.; Zhen, W.; Shirasawa, S.; Sasazuki, T.; Solit, DB ; Rosen, N. "4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors." Cancer cell 18, 1 (2010): 39-51. [PubMed Link] | [ Full text ]
Cherrin, C.; Haskell, K.; Howell, B.; Jones, R.; Leander, K.; Robinson, R.; Watkins, A.; Bilodeau, M.; Hoffman, J.; Sanderson, P.; Hartman, G.; Mahan, E.; Prueksaritanont, T.; Jiang, G.; She, QB ; Rosen, N.; Sepp-Lorenzino, L.; Defeo-Jones, D.; Huber, HE "An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo." Cancer biology & therapy 9, 7 (2010): 493-503. [PubMed Link] | [ Full text ]
She, QB ; Chandarlapaty, S.; Ye, Q.; Lobo, J.; Haskell, KM ; Leander, KR ; Defeo-Jones, D.; Huber, HE ; Rosen, N. "Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling." PloS one 3, 8 (2008): e3065. [PubMed Link] | [ Full text ]
Nelander, S.; Wang, W.; Nilsson, B.; She, QB ; Pratilas, C.; Rosen, N.; Gennemark, P.; Sander, C. "Models from experiments: combinatorial drug perturbations of cancer cells." Molecular systems biology 4, (2008): 216. [PubMed Link] | [ Full text ]
Saal, LH ; Johansson, P.; Holm, K.; Gruvberger-Saal, SK ; She, QB ; Maurer, M.; Koujak, S.; Ferrando, AA ; Malmström, P.; Memeo, L.; Isola, J.; Bendahl, PO ; Rosen, N.; Hibshoosh, H.; Ringnér, M.; Borg, A.; Parsons, R. "Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity." Proceedings of the National Academy of Sciences of the United States of America 104, 18 (2007): 7564-9. [PubMed Link] | [ Full text ]
Rosen, N.; She, QB "AKT and cancer--is it all mTOR?" Cancer cell 10, 4 (2006): 254-6. [PubMed Link] | [ Full text ]
O'Reilly, KE ; Rojo, F.; She, QB ; Solit, D.; Mills, GB ; Smith, D.; Lane, H.; Hofmann, F.; Hicklin, DJ ; Ludwig, DL ; Baselga, J.; Rosen, N. "mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt." Cancer research 66, 3 (2006): 1500-8. [PubMed Link] | [ Full text ]
She, QB ; Solit, DB ; Ye, Q.; O'Reilly, KE ; Lobo, J.; Rosen, N. "The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells." Cancer cell 8, 4 (2005): 287-97. [PubMed Link] | [ Full text ]
She, QB ; Solit, D.; Basso, A.; Moasser, MM "Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling." Clinical cancer research : an official journal of the American Association for Cancer Research 9, 12 (2003): 4340-6. [PubMed Link] | [ Full text ]
Kaji, A.; Zhang, Y.; Nomura, M.; Bode, AM ; Ma, WY ; She, QB ; Dong, Z. "Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells." Molecular carcinogenesis 37, 3 (2003): 138-48. [PubMed Link] | [ Full text ]
She, QB ; Ma, WY ; Wang, M.; Kaji, A.; Ho, CT ; Dong, Z. "Inhibition of cell transformation by resveratrol and its derivatives: differential effects and mechanisms involved." Oncogene 22, 14 (2003): 2143-50. [PubMed Link] | [ Full text ]
She, QB ; Chen, N.; Bode, AM ; Flavell, RA ; Dong, Z. "Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate." Cancer research 62, 5 (2002): 1343-8. [PubMed Link] | [ Full text ]
Chen, N.; She, QB ; Bode, AM ; Dong, Z. "Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells." Cancer research 62, 5 (2002): 1300-4. [PubMed Link] | [ Full text ]
She, QB ; Ma, WY ; Zhong, S.; Dong, Z. "Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation." The Journal of biological chemistry 277, 27 (2002): 24039-48. [PubMed Link] | [ Full text ]
She, QB ; Ma, WY ; Dong, Z. "Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20." Oncogene 21, 10 (2002): 1580-9. [PubMed Link] | [ Full text ]
She, QB ; Huang, C.; Zhang, Y.; Dong, Z. "Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis." Molecular carcinogenesis 33, 4 (2002): 244-50. [PubMed Link] | [ Full text ]
Chen, N.; Nomura, M.; She, QB ; Ma, WY ; Bode, AM ; Wang, L.; Flavell, RA ; Dong, Z. "Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice." Cancer research 61, 10 (2001): 3908-12. [PubMed Link] | [ Full text ]
She, QB ; Bode, AM ; Ma, WY ; Chen, NY ; Dong, Z. "Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase." Cancer research 61, 4 (2001): 1604-10. [PubMed Link] | [ Full text ]
Chen, N.; Ma, WY ; She, QB ; Wu, E.; Liu, G.; Bode, AM ; Dong, Z. "Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction." The Journal of biological chemistry 276, 50 (2001): 46722-8. [PubMed Link] | [ Full text ]
Zhong, S.; Jansen, C.; She, QB ; Goto, H.; Inagaki, M.; Bode, AM ; Ma, WY ; Dong, Z. "Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1." The Journal of biological chemistry 276, 35 (2001): 33213-9. [PubMed Link] | [ Full text ]
She, QB ; Mukherjee, JJ ; Chung, T.; Kiss, Z. "Placental alkaline phosphatase, insulin, and adenine nucleotides or adenosine synergistically promote long-term survival of serum-starved mouse embryo and human fetus fibroblasts." Cellular signalling 12, 9-10 (2000): 659-65. [PubMed Link] | [ Full text ]
She, QB ; Mukherjee, JJ ; Crilly, KS ; Kiss, Z. "alpha(1)-antitrypsin can increase insulin-induced mitogenesis in various fibroblast and epithelial cell lines." FEBS letters 473, 1 (2000): 33-6. [PubMed Link] | [ Full text ]
She, QB ; Mukherjee, JJ ; Huang, JS ; Crilly, KS ; Kiss, Z. "Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts." FEBS letters 469, 2-3 (2000): 163-7. [PubMed Link] | [ Full text ]
She, QB ; Chen, N.; Dong, Z. "ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation." The Journal of biological chemistry 275, 27 (2000): 20444-9. [PubMed Link] | [ Full text ]
Huang, JS ; She, QB ; Crilly, KS ; Kiss, Z. "Ethanol, Zn2+ and insulin interact as progression factors to enhance DNA synthesis synergistically in the presence of Ca2+ and other cell cycle initiators in fibroblasts." The Biochemical journal 346 Pt 1, (2000): 241-7. [PubMed Link] |
She, QB ; Huang, JS ; Mukherjee, JJ ; Crilly, KS ; Kiss, Z. "The possible mechanism of synergistic effects of ethanol, zinc and insulin on DNA synthesis in NIH 3T3 fibroblasts." FEBS letters 460, 2 (1999): 199-202. [PubMed Link] | [ Full text ]
She, QB ; Ng, TB ; Liu, WK "A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea." Biochemical and biophysical research communications 247, 1 (1998): 106-11. [PubMed Link] | [ Full text ]
She, QB ; Hayakawa, T.; Tsuge, H. "Alteration in the phosphatidylcholine biosynthesis of rat liver microsomes caused by vitamin B6 deficiency." Bioscience, biotechnology, and biochemistry 59, 2 (1995): 163-7. [PubMed Link] | [ Full text ]
She, QB ; Nagao, I.; Hayakawa, T.; Tsuge, H. "A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver." Biochemical and biophysical research communications 205, 3 (1994): 1748-54. [PubMed Link] | [ Full text ]