Brandon Fornwalt, M.D., Ph.D.

Bio / Education: 
  • University of South Carolina, B.S. Honors, Mathematics and Marine Science, 2002
  • Georgia Institute of Technology, Ph.D, Biomedical Engineering, 2008
  • Emory University  School of Medicine, Postdoctoral, Radiology, 2009
  • Emory University School of Medicine, M.D., 2010
  • Children's Hospital Boston and Harvard Medical School, Pediatric Internship, 2011
Research Description: 

The Fornwalt Lab (www.fornwaltlab.com) aims to use both echocardiography and magnetic resonance imaging (MRI) in children with heart disease to improve clinical practice. We are particularly interested in understanding normal patterns of contraction in the heart, how these patterns are different in children with heart failure, and what treatments can be provided in order to correct abnormal contraction. We are also using MRI to explore the cardiovascular effects of obesity in both animal models and children.

High Resolution Displacement Encoded Imaging of a Human Heart:

 

Motion Trajectories of the Human Heart Derived from DENSE:

 

Mouse (left) vs Human (right) Cine MR Imaging:

Grants: 
National Institutes of Health Director's Early Independence Award Use magnetic resonance imaging (MRI) to comprehensively investigate the role of cardiac dyssynchrony in patients with tetralogy of Fallot. See press release. Brandon Fornwalt, MD, PhD
Pilot project from the NIH (Grants 5P20RR021954-05 and 8P20GM103527-05) Center of Research in Obesity and Cardiovascular Disease Develop and validate techniques using magnetic resonance imaging to understand the cardiovascular effects of obesity in mouse models Brandon Fornwalt, MD, PhD
Friends Research Fund, Children's Healthcare of Atlanta To determine the best method for diagnosing left ventricular dyssynchrony in children Brandon Fornwalt, MD, PhD
Children's Miracle Network, University of Kentucky To determine the best method for diagnosing left ventricular dyssynchrony in children Brandon Fornwalt, MD, PhD
Children's Miracle Network, University of Kentucky To integrate cellular-level data into age-specific computational models that predict global measures of ventricular function in young rats Kenneth Campbell, PhD
Faculty Startup Funds, University of Kentucky Create an independent research program which uses cardiovascular imaging in children with heart disease to help understand physiology and inform clinical decisions Brandon Fornwalt, MD, PhD
PubMed Publications: 

  • Wehner, G.J.;Suever, J.D.;Haggerty, C.M.;Jing, L.;Powell, D.K.;Hamlet, S.M.;Grabau, J.D.;Mojsejenko, W.D.;Zhong, X.;Epstein, F.H.;Fornwalt, B.K. "Validation of in vivo 2D displacements from spiral cine DENSE at 3T." Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 17, 1 (2015): 5. [PubMed Link] | [ Full text ]
  • Davis, F.M.;Rateri, D.L.;Balakrishnan, A.;Howatt, D.A.;Strickland, D.K.;Muratoglu, S.C.;Haggerty, C.M.;Fornwalt, B.K.;Cassis, L.A.;Daugherty, A. "Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 35, 1 (2015): 155-62. [PubMed Link] | [ Full text ]
  • Haggerty, C.M.;Mattingly, A.C.;Gong, M.C.;Su, W.;Daugherty, A.;Fornwalt, B.K. "Telemetric Blood Pressure Assessment in Angiotensin II-Infused ApoE-/- Mice: 28 Day Natural History and Comparison to Tail-Cuff Measurements." PloS one 10, 6 (2015): e0130723. [PubMed Link] | [ Full text ]
  • Suever, J.D.;Wehner, G.J.;Haggerty, C.M.;Jing, L.;Hamlet, S.M.;Binkley, C.M.;Kramer, S.P.;Mattingly, A.C.;Powell, D.K.;Bilchick, K.C.;Epstein, F.H.;Fornwalt, B.K. "Simplified post processing of cine DENSE cardiovascular magnetic resonance for quantification of cardiac mechanics." Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 16, (2014): 94. [PubMed Link] | [ Full text ]
  • Whitbeck, M.G.;Charnigo, R.J.;Shah, J.;Morales, G.;Leung, S.W.;Fornwalt, B.;Bailey, A.L.;Ziada, K.;Sorrell, V.L.;Zegarra, M.M.;Thompson, J.;Hosn, N.A.;Campbell, C.L.;Gurley, J.;Anaya, P.;Booth, D.C.;Di Biase, L.;Natale, A.;Smyth, S.;Moliterno, D.J.;Elayi, C.S.;AFFIRM, "QRS duration predicts death and hospitalization among patients with atrial fibrillation irrespective of heart failure: evidence from the AFFIRM study." Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 6 (2014): 803-11. [PubMed Link] | [ Full text ]
  • Jing, L.;Haggerty, C.M.;Suever, J.D.;Alhadad, S.;Prakash, A.;Cecchin, F.;Skrinjar, O.;Geva, T.;Powell, A.J.;Fornwalt, B.K. "Patients with repaired tetralogy of Fallot suffer from intra- and inter-ventricular cardiac dyssynchrony: a cardiac magnetic resonance study." European heart journal cardiovascular Imaging 15, 12 (2014): 1333-43. [PubMed Link] |
  • Haggerty, C.M.;Kramer, S.P.;Skrinjar, O.;Binkley, C.M.;Powell, D.K.;Mattingly, A.C.;Epstein, F.H.;Fornwalt, B.K. "Quantification of left ventricular volumes, mass, and ejection fraction using cine displacement encoding with stimulated echoes (DENSE) MRI." Journal of magnetic resonance imaging : JMRI 40, 2 (2014): 398-406. [PubMed Link] | [ Full text ]
  • Suever, J.D.;Fornwalt, B.K.;Neuman, L.R.;Delfino, J.G.;Lloyd, M.S.;Oshinski, J.N. "Method to create regional mechanical dyssynchrony maps from short-axis cine steady-state free-precession images." Journal of magnetic resonance imaging : JMRI 39, 4 (2014): 958-65. [PubMed Link] | [ Full text ]
  • Thomas, V.C.;Cumbermack, K.M.;Lamphier, C.K.;Phillips, C.R.;Fyfe, D.A.;Fornwalt, B.K. "Measures of dyssynchrony in the left ventricle of healthy children and young patients with dilated cardiomyopathy." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 26, 2 (2013): 142-53. [PubMed Link] | [ Full text ]
  • Costello, J.R.;Mullins, M.E.;Votaw, J.R.;Karolyi, D.R.;Kalb, B.;Gonzales, P.;Fornwalt, B.;Meltzer, C.C. "Establishing a new radiology residency research track." Academic radiology 20, 2 (2013): 243-8. [PubMed Link] | [ Full text ]
  • Kramer, S.P.;Powell, D.K.;Haggerty, C.M.;Binkley, C.M.;Mattingly, A.C.;Cassis, L.A.;Epstein, F.H.;Fornwalt, B.K. "Obesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study." Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15, (2013): 109. [PubMed Link] | [ Full text ]
  • Haggerty, C.M.;Kramer, S.P.;Binkley, C.M.;Powell, D.K.;Mattingly, A.C.;Charnigo, R.;Epstein, F.H.;Fornwalt, B.K. "Reproducibility of cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance for measuring left ventricular strains, torsion, and synchrony in mice." Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15, (2013): 71. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;León, A.R.;Oshinski, J.N. "Regarding article "relationship of echocardiographic dyssynchrony to long-term survival after cardiac resynchronization therapy"." Circulation 124, 2 (2011): e37; author reply e38. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K. "The dyssynchrony in predicting response to cardiac resynchronization therapy: a call for change." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 24, 2 (2011): 180-4. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Sprague, W.W.;BeDell, P.;Suever, J.D.;Gerritse, B.;Merlino, J.D.;Fyfe, D.A.;León, A.R.;Oshinski, J.N. "Agreement is poor among current criteria used to define response to cardiac resynchronization therapy." Circulation 121, 18 (2010): 1985-91. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Sprague, W.W.;Carew, J.D.;Merlino, J.D.;Fyfe, D.A.;León, A.R.;Oshinski, J.N. "Variability in tissue Doppler echocardiographic measures of dyssynchrony is reduced with use of a larger region of interest." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 22, 5 (2009): 478-85.e3. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Delfino, J.G.;Sprague, W.W.;Oshinski, J.N. "It's time for a paradigm shift in the quantitative evaluation of left ventricular dyssynchrony." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 22, 6 (2009): 672-6. [PubMed Link] | [ Full text ]
  • Delfino, J.G.;Fornwalt, B.K.;Oshinski, J.N.;Lerakis, S. "Role of MRI in patient selection for CRT." Echocardiography (Mount Kisco, N.Y.) 25, 10 (2008): 1176-85. [PubMed Link] | [ Full text ]
  • Delfino, J.G.;Fornwalt, B.K.;Eisner, R.L.;Leon, A.R.;Oshinski, J.N. "Cross-correlation delay to quantify myocardial dyssynchrony from phase contrast magnetic resonance (PCMR) velocity data." Journal of magnetic resonance imaging : JMRI 28, 5 (2008): 1086-91. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Cummings, R.M.;Arita, T.;Delfino, J.G.;Fyfe, D.A.;Campbell, R.M.;Strieper, M.J.;Oshinski, J.N.;Frias, P.A. "Acute pacing-induced dyssynchronous activation of the left ventricle creates systolic dyssynchrony with preserved diastolic synchrony." Journal of cardiovascular electrophysiology 19, 5 (2008): 483-8. [PubMed Link] | [ Full text ]
  • Delfino, J.G.;Fornwalt, B.K.;Eisner, R.L.;Leon, A.R.;Oshinski, J.N. "Determination of transmural, endocardial, and epicardial radial strain and strain rate from phase contrast MR velocity data." Journal of magnetic resonance imaging : JMRI 27, 3 (2008): 522-8. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Thomas, J.A.;Bhasin, M.;Merlino, J.D.;León, A.R.;Fyfe, D.A.;Oshinski, J.N. "Effects of region of interest tracking on the diagnosis of left ventricular dyssynchrony from Doppler tissue images." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 21, 3 (2008): 234-40. [PubMed Link] | [ Full text ]
  • Fielden, S.W.;Fornwalt, B.K.;Jerosch-Herold, M.;Eisner, R.L.;Stillman, A.E.;Oshinski, J.N. "A new method for the determination of aortic pulse wave velocity using cross-correlation on 2D PCMR velocity data." Journal of magnetic resonance imaging : JMRI 27, 6 (2008): 1382-7. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Gonzales, P.C.;Delfino, J.G.;Eisner, R.;León, A.R.;Oshinski, J.N. "Quantification of left ventricular internal flow from cardiac magnetic resonance images in patients with dyssynchronous heart failure." Journal of magnetic resonance imaging : JMRI 28, 2 (2008): 375-81. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Mahle, W.T.;Fyfe, D.A. "Resynchronization and strain recovery following reimplantation of anomalous coronary artery: a tissue Doppler and three-dimensional echocardiographic study." Congenital heart disease 2, 1 (2007): 58-63. [PubMed Link] | [ Full text ]
  • Fornwalt, B.K.;Arita, T.;Bhasin, M.;Voulgaris, G.;Merlino, J.D.;León, A.R.;Fyfe, D.A.;Oshinski, J.N. "Cross-correlation quantification of dyssynchrony: a new method for quantifying the synchrony of contraction and relaxation in the heart." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20, 12 (2007): 1330-1337.e1. [PubMed Link] | [ Full text ]
  • Sundareshwar, P.V.;Morris, J.T.;Koepfler, E.K.;Fornwalt, B. "Phosphorus limitation of coastal ecosystem processes." Science (New York, N.Y.) 299, 5606 (2003): 563-5. [PubMed Link] | [ Full text ]