B. Mark Evers, MD, FACS

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About
Education
Publications

mark.evers@uky.edu

Position(s):

Professor of Surgery

Mark McDowell Cancer Foundation Chair in the Lucille P. Markey Cancer Center

Director, Markey Cancer Center

Physician-In-Chief, Oncology Service

Affiliation(s):

Lucille Parker Markey Cancer Center

Surgery

Other Affiliation(s):

Surgery/General

Surgical Oncology

MD/PhD Program Internal Advisory Committee

MD/PhD Program Mentor

Bio / Education:

Medical School
summa cum laude
University of Tennessee, Memphis, TN

Residency
University of Louisville, Louisville, KY

Fellowship - Research
University of Texas Medical Branch, Galveston, TX

Surgical Interests
Gastrointestinal surgery
Oncology

PubMed Publications:

Chauhan, A.; Farooqui, Z.; Silva, SR ; Murray, A.; Hodges, KB ; Yu, Q.; Myint, ZW ; Raajesekar, AK ; Weiss, H.; Arnold, S.; Evers, BM ; Anthony, L. "Integrating a 92-Gene Expression Analysis for the Management of Neuroendocrine Tumors of Unknown Primary" Asian Pacific journal of cancer prevention : APJCP 20, 1 (2019): 113-116. [PubMed Link] | [ Full text ]
Gan, T.; Sinner, HF ; Walling, SC ; Chen, Q.; Huang, B.; Tucker, TC ; Patel, JA ; Evers, BM ; Bhakta, AS "Impact of the Affordable Care Act on Colorectal Cancer Screening, Incidence, and Survival in Kentucky." Journal of the American College of Surgeons (2019): [PubMed Link] | [ Full text ]
Jafari, N.; Drury, J ; Morris, AJ ; Onono, FO ; Stevens, PD ; Gao, T.; Liu, J.; Wang, C.; Lee, EY ; Weiss, HL ; Evers, BM ; Zaytseva, YY "<i>De Novo</i> Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer." Molecular cancer research : MCR 17, 1 (2019): 140-152. [PubMed Link] | [ Full text ]
Frohman, HA ; Rychahou, PG ; Li, J.; Gan, T.; Evers, BM "Development of murine bariatric surgery models: lessons learned." The Journal of surgical research 229, (2018): 302-310. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Rychahou, P.; Harris, JW ; Zaytseva, YY ; Liu, J.; Wang, C.; Weiss, HL ; Liu, C.; Lee, EY ; Evers, BM "Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth." Cancer research 78, 12 (2018): 3163-3175. [PubMed Link] | [ Full text ]
Pi, F.; Binzel, DW ; Lee, TJ ; Li, Z.; Sun, M.; Rychahou, P.; Li, H.; Haque, F.; Wang, S.; Croce, CM ; Guo, B.; Evers, BM ; Guo, P. "Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression." Nature nanotechnology 13, 1 (2018): 82-89. [PubMed Link] |
Wen, YA ; Xiong, X.; Zaytseva, YY ; Napier, DL ; Vallee, E.; Li, AT ; Wang, C.; Weiss, HL ; Evers, BM ; Gao, T. "Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer." Cell death & disease 9, 3 (2018): 265. [PubMed Link] | [ Full text ]
Kim, JT ; Napier, DL ; Weiss, HL ; Lee, EY ; Townsend CM, Jr ; Evers, BM "Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration." Neoplasia (New York, N.Y.) 20, 2 (2018): 175-181. [PubMed Link] | [ Full text ]
Liu, J.; Duan, Z.; Guo, W.; Zeng, L.; Wu, Y.; Chen, Y.; Tai, F ; Wang, Y.; Lin, Y.; Zhang, Q.; He, Y.; Deng, J.; Stewart, RL ; Wang, C.; Lin, PC ; Ghaffari, S ; Evers, BM ; Liu, S.; Zhou, MM ; Zhou, BP ; Shi, J. "Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer." Nature communications 9, 1 (2018): 5200. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Li, X.; Rock, SB ; Sinner, HF ; Weiss, HL ; Weiss, T.; Townsend CM, Jr ; Gao, T.; Evers, BM "FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice." Endocrinology 159, 8 (2018): 2939-2952. [PubMed Link] | [ Full text ]
Chauhan, A.; Farooqui, Z.; Murray, LA ; Weiss, HL ; War Myint, Z.; Raajasekar, AKA ; Evers, BM ; Arnold, S.; Anthony, L. "Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary." Journal of oncology 2018, (2018): 3519247. [PubMed Link] | [ Full text ]
Lin, Y.; Wang, Y.; Shi, Q.; Yu, Q.; Liu, C.; Feng, J.; Deng, J.; Evers, BM ; Zhou, BP ; Wu, Y. "Stabilization of the transcription factors slug and twist by the deubiquitinase dub3 is a key requirement for tumor metastasis." Oncotarget 8, 43 (2017): 75127-75140. [PubMed Link] | [ Full text ]
Mitov, MI ; Harris, JW ; Alstott, MC ; Zaytseva, YY ; Evers, BM ; Butterfield, DA "Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines." Experimental cell research 354, 2 (2017): 112-121. [PubMed Link] | [ Full text ]
Kenlan, DE ; Rychahou, P.; Sviripa, VM ; Weiss, HL ; Liu, C.; Watt, DS ; Evers, BM "Fluorinated N,N'-Diarylureas As Novel Therapeutic Agents Against Cancer Stem Cells." Molecular cancer therapeutics 16, 5 (2017): 831-837. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Rychahou, P.; Fan, TW ; Lane, AN ; Weiss, HL ; Evers, BM "Ketogenesis contributes to intestinal cell differentiation." Cell death and differentiation 24, 3 (2017): 458-468. [PubMed Link] | [ Full text ]
Kim, JT ; Weiss, HL ; Evers, BM "Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells." International journal of oncology 50, 6 (2017): 2200-2206. [PubMed Link] | [ Full text ]
Wu, Y.; Wang, Y.; Lin, Y.; Liu, Y.; Wang, Y.; Jia, J.; Singh, P.; Chi, YI ; Wang, C.; Dong, C.; Li, W.; Tao, M.; Napier, D.; Shi, Q.; Deng, J.; Evers, BM ; Zhou, BP "Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation." Nature communications 8, (2017): 14228. [PubMed Link] | [ Full text ]
Wang, J.; Ye, Q.; Cao, Y.; Guo, Y.; Huang, X.; Mi, W.; Liu, S.; Wang, C.; Yang, HS ; Zhou, BP ; Evers, BM ; She, QB "Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1." Nature communications 8, 1 (2017): 2207. [PubMed Link] | [ Full text ]
Gao, T.; Evers, BM "Colorectal cancer: A new innate immune sensor - functions from inside the colonic epithelium." Nature reviews. Gastroenterology & hepatology 14, 4 (2017): 199-200. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Zaytseva, YY ; Liu, Y.; Rychahou, P.; Jiang, K.; Starr, ME ; Kim, JT ; Harris, JW ; Yiannikouris, FB ; Katz, WS ; Nilsson, PM ; Orho-Melander, M.; Chen, J.; Zhu, H.; Fahrenholz, T.; Higashi, RM ; Gao, T.; Morris, AJ ; Cassis, LA ; Fan, TW ; Weiss, HL ; Dobner, PR ; Melander, O.; Jia, J.; Evers, BM "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
Yu, T.; Chen, X.; Lin, T.; Liu, J.; Li, M.; Zhang, W.; Xu, X.; Zhao, W.; Liu, M.; Napier, DL ; Wang, C.; Evers, BM ; Liu, C. "KLF4 deletion alters gastric cell lineage and induces MUC2 expression." Cell death & disease 7, 6 (2016): e2255. [PubMed Link] | [ Full text ]
Upreti, M.; Jyoti, A.; Johnson, SE ; Swindell, EP ; Napier, D.; Sethi, P.; Chan, R.; Feddock, JM ; Weiss, HL ; O'Halloran, TV ; Evers, BM "Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer." Oncotarget 7, 27 (2016): 41559-41574. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Weiss, HL ; Weiss, T.; Townsend CM, Jr ; Evers, BM "Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells." Molecular endocrinology (Baltimore, Md.) 30, 1 (2016): 26-36. [PubMed Link] | [ Full text ]
Jiang, K.; Liu, Y.; Fan, J.; Zhang, J.; Li, XA ; Evers, BM ; Zhu, H.; Jia, J. "PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail." PLoS biology 14, 2 (2016): e1002375. [PubMed Link] | [ Full text ]
Vilchez, V.; Turcios, L.; Zaytseva, Y.; Stewart, R.; Lee, EY ; Maynard, E.; Shah, MB ; Daily, MF ; Tzeng, CW ; Davenport, D.; Castellanos, AL ; Krohmer, S.; Hosein, PJ ; Evers, BM ; Gedaly, R. "Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma." American journal of surgery 212, 2 (2016): 238-45. [PubMed Link] | [ Full text ]
Sharma, A.; Haque, F.; Pi, F.; Shlyakhtenko, LS ; Evers, BM ; Guo, P. "Controllable self-assembly of RNA dendrimers." Nanomedicine : nanotechnology, biology, and medicine 12, 3 (2016): 835-844. [PubMed Link] | [ Full text ]
Kim, JT ; Li, J.; Song, J.; Lee, EY ; Weiss, HL ; Townsend CM, Jr ; Evers, BM "Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells." Oncotarget 6, 29 (2015): 26960-70. [PubMed Link] | [ Full text ]
Wydra, RJ ; Rychahou, PG ; Evers, BM ; Anderson, KW ; Dziubla, TD ; Hilt, JZ "The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity." Acta biomaterialia 25, (2015): 284-90. [PubMed Link] | [ Full text ]
Kim, JT ; Liu, C.; Zaytseva, YY ; Weiss, HL ; Townsend CM, Jr ; Evers, BM "Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells." International journal of cancer 136, 6 (2015): 1475-81. [PubMed Link] | [ Full text ]
Starr, ME ; Takahashi, H.; Okamura, D.; Zwischenberger, BA ; Mrazek, AA ; Ueda, J.; Stromberg, AJ ; Evers, BM ; Esmon, CT ; Saito, H. "Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis." American journal of physiology. Heart and circulatory physiology 308, 2 (2015): H83-91. [PubMed Link] | [ Full text ]
Zhou, Y.; Rychahou, P.; Wang, Q.; Weiss, HL ; Evers, BM "TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium." Cell death & disease 6, (2015): e1631. [PubMed Link] | [ Full text ]
Rychahou, P.; Haque, F.; Shu, Y ; Zaytseva, Y.; Weiss, HL ; Lee, EY ; Mustain, W.; Valentino, J.; Guo, P.; Evers, BM "Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration." ACS nano 9, 2 (2015): 1108-16. [PubMed Link] | [ Full text ]
Starr, ME ; Saito, M.; Evers, BM ; Saito, H. "Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue." The journals of gerontology. Series A, Biological sciences and medical sciences 70, 12 (2015): 1508-15. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Harris, JW ; Mitov, MI ; Kim, JT ; Butterfield, DA ; Lee, EY ; Weiss, HL ; Gao, T.; Evers, BM "Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration." Oncotarget 6, 22 (2015): 18891-904. [PubMed Link] | [ Full text ]
Li, H.; Rychahou, PG ; Cui, Z.; Pi, F.; Evers, BM ; Shu, D.; Guo, P.; Luo, W. "RNA Nanoparticles Derived from Three-Way Junction of Phi29 Motor pRNA Are Resistant to I-125 and Cs-131 Radiation." Nucleic acid therapeutics 25, 4 (2015): 188-97. [PubMed Link] | [ Full text ]
Zhu, J.; Xiong, G.; Fu, H.; Evers, BM ; Zhou, BP ; Xu, R. "Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network." Cancer research 75, 8 (2015): 1580-91. [PubMed Link] | [ Full text ]
Evers, BM "The evolving role of the surgeon scientist." Journal of the American College of Surgeons 220, 4 (2015): 387-95. [PubMed Link] | [ Full text ]
Rychahou, P.; Shu, Y ; Haque, F.; Hu, J.; Guo, P.; Evers, BM "Methods and assays for specific targeting and delivery of RNA nanoparticles to cancer metastases." Methods in molecular biology (Clifton, N.J.) 1297, (2015): 121-35. [PubMed Link] | [ Full text ]
Zhou, Y.; Wang, Q.; Weiss, HL ; Evers, BM "Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway." Molecular biology of the cell 25, 18 (2014): 2882-90. [PubMed Link] | [ Full text ]
Bailey, MB ; Davenport, DL ; Vargas, HD ; Evers, BM ; McKenzie, SP "Longer operative time: deterioration of clinical outcomes of laparoscopic colectomy versus open colectomy." Diseases of the colon and rectum 57, 5 (2014): 616-22. [PubMed Link] | [ Full text ]
Valentino, JD ; Li, J.; Zaytseva, YY ; Mustain, WC ; Elliott, VA ; Kim, JT ; Harris, JW ; Campbell, K.; Weiss, H.; Wang, C.; Song, J.; Anthony, L.; Townsend CM, Jr ; Evers, BM "Cotargeting the PI3K and RAS pathways for the treatment of neuroendocrine tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 20, 5 (2014): 1212-22. [PubMed Link] | [ Full text ]
Hollis, CP ; Weiss, HL ; Evers, BM ; Gemeinhart, RA ; Li, T. "In vivo investigation of hybrid Paclitaxel nanocrystals with dual fluorescent probes for cancer theranostics." Pharmaceutical research 31, 6 (2014): 1450-9. [PubMed Link] | [ Full text ]
McKenzie, SP ; Vargas, HD ; Evers, BM ; Davenport, DL "Selection criteria for combined resection of synchronous colorectal cancer hepatic metastases: a cautionary note." International journal of colorectal disease 29, 6 (2014): 729-35. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Elliott, VA ; Rychahou, P.; Mustain, WC ; Kim, JT ; Valentino, J.; Gao, T.; O'Connor, KL ; Neltner, JM ; Lee, EY ; Weiss, HL ; Evers, BM "Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer." Carcinogenesis 35, 6 (2014): 1341-51. [PubMed Link] | [ Full text ]
Shi, J.; Wang, Y.; Zeng, L.; Wu, Y.; Deng, J.; Zhang, Q.; Lin, Y.; Li, J.; Kang, T.; Tao, M.; Rusinova, E.; Zhang, G.; Wang, C.; Zhu, H.; Yao, J.; Zeng, YX ; Evers, BM ; Zhou, MM ; Zhou, BP "Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer." Cancer cell 25, 2 (2014): 210-25. [PubMed Link] | [ Full text ]
Shu, Y ; Pi, F.; Sharma, A.; Rajabi, M.; Haque, F.; Shu, D.; Leggas, M.; Evers, BM ; Guo, P. "Stable RNA nanoparticles as potential new generation drugs for cancer therapy." Advanced drug delivery reviews 66, (2014): 74-89. [PubMed Link] | [ Full text ]
Ye, Q.; Cai, W.; Zheng, Y.; Evers, BM ; She, QB "ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer." Oncogene 33, 14 (2014): 1828-39. [PubMed Link] | [ Full text ]
Gedaly, R.; Galuppo, R.; Daily, MF ; Shah, M.; Maynard, E.; Chen, C.; Zhang, X.; Esser, KA ; Cohen, DA ; Evers, BM ; Jiang, J.; Spear, BT "Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535." PloS one 9, 6 (2014): e99272. [PubMed Link] | [ Full text ]
Elliott, VA ; Rychahou, P.; Zaytseva, YY ; Evers, BM "Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model." PloS one 9, 5 (2014): e97432. [PubMed Link] | [ Full text ]
Starr, ME ; Steele, AM ; Saito, M.; Hacker, BJ ; Evers, BM ; Saito, H. "A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis." PloS one 9, 12 (2014): e115705. [PubMed Link] | [ Full text ]
Wu, Y.; Wang, Y.; Yang, XH ; Kang, T.; Zhao, Y.; Wang, C.; Evers, BM ; Zhou, BP "The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells." Cell reports 5, 1 (2013): 224-36. [PubMed Link] | [ Full text ]
Hollis, CP ; Weiss, HL ; Leggas, M.; Evers, BM ; Gemeinhart, RA ; Li, T. "Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery." Journal of controlled release : official journal of the Controlled Release Society 172, 1 (2013): 12-21. [PubMed Link] | [ Full text ]
Wang, S.; Haque, F.; Rychahou, PG ; Evers, BM ; Guo, P. "Engineered nanopore of Phi29 DNA-packaging motor for real-time detection of single colon cancer specific antibody in serum." ACS nano 7, 11 (2013): 9814-22. [PubMed Link] | [ Full text ]
Gedaly, R.; Galuppo, R.; Musgrave, Y.; Angulo, P.; Hundley, J.; Shah, M.; Daily, MF ; Chen, C.; Cohen, DA ; Spear, BT ; Evers, BM "PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation." The Journal of surgical research 185, 1 (2013): 225-30. [PubMed Link] | [ Full text ]
Kim, JT ; Li, J.; Jang, ER ; Gulhati, P.; Rychahou, PG ; Napier, DL ; Wang, C.; Weiss, HL ; Lee, EY ; Anthony, L.; Townsend CM, Jr ; Liu, C.; Evers, BM "Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors." Carcinogenesis 34, 5 (2013): 953-61. [PubMed Link] | [ Full text ]
Dong, C.; Yuan, T.; Wu, Y.; Wang, Y.; Fan, TW ; Miriyala, S.; Lin, Y.; Yao, J.; Shi, J.; Kang, T.; Lorkiewicz, P.; St Clair, D.; Hung, MC ; Evers, BM ; Zhou, BP "Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer." Cancer cell 23, 3 (2013): 316-31. [PubMed Link] | [ Full text ]
Dong, C.; Wu, Y.; Wang, Y.; Wang, C.; Kang, T.; Rychahou, PG ; Chi, YI ; Evers, BM ; Zhou, BP "Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer." Oncogene 32, 11 (2013): 1351-62. [PubMed Link] | [ Full text ]
Li, X.; Zhou, Q.; Sunkara, M.; Kutys, ML ; Wu, Z.; Rychahou, P.; Morris, AJ ; Zhu, H.; Evers, BM ; Huang, C. "Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration." Journal of cell science 126, Pt 12 (2013): 2617-28. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Rychahou, P.; Liu, C.; Weiss, HL ; Evers, BM "NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation." Cell death & disease 4, (2013): e671. [PubMed Link] | [ Full text ]
Li, X.; Stevens, PD ; Yang, H.; Gulhati, P.; Wang, W.; Evers, BM ; Gao, T. "The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer." Oncogene 32, 4 (2013): 471-8. [PubMed Link] | [ Full text ]
Valentino, JD ; Rychahou, PG ; Mustain, WC ; Elliott, VA ; Evers, BM "Murine portal vein catheterization to analyze liver-directed therapies." The Journal of surgical research 185, 2 (2013): 690-6. [PubMed Link] | [ Full text ]
Zhang, W.; Sviripa, V.; Chen, X.; Shi, J.; Yu, T.; Hamza, A.; Ward, ND ; Kril, LM ; Vander Kooi, CW ; Zhan, CG ; Evers, BM ; Watt, DS ; Liu, C. "Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A." ACS chemical biology 8, 4 (2013): 796-803. [PubMed Link] | [ Full text ]
Starr, ME ; Hu, Y.; Stromberg, AJ ; Carmical, JR ; Wood, TG ; Evers, BM ; Saito, H. "Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors." Aging cell 12, 2 (2013): 194-206. [PubMed Link] | [ Full text ]
Mustain, WC ; Starr, ME ; Valentino, JD ; Cohen, DA ; Okamura, D.; Wang, C.; Evers, BM ; Saito, H. "Inflammatory cytokine gene expression in mesenteric adipose tissue during acute experimental colitis." PloS one 8, 12 (2013): e83693. [PubMed Link] | [ Full text ]
Gulhati, P.; Zaytseva, YY ; Valentino, JD ; Stevens, PD ; Kim, JT ; Sasazuki, T.; Shirasawa, S.; Lee, EY ; Weiss, HL ; Dong, J.; Gao, T.; Evers, BM "Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA." Carcinogenesis 33, 9 (2012): 1782-90. [PubMed Link] | [ Full text ]
Okamura, D.; Starr, ME ; Lee, EY ; Stromberg, AJ ; Evers, BM ; Saito, H. "Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis." Aging cell 11, 5 (2012): 760-9. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Rychahou, PG ; Gulhati, P.; Elliott, VA ; Mustain, WC ; O'Connor, K.; Morris, AJ ; Sunkara, M.; Weiss, HL ; Lee, EY ; Evers, BM "Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer." Cancer research 72, 6 (2012): 1504-17. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Valentino, JD ; Gulhati, P.; Evers, BM "mTOR inhibitors in cancer therapy." Cancer letters 319, 1 (2012): 1-7. [PubMed Link] | [ Full text ]
Wang, X.; Mandal, AK ; Saito, H.; Pulliam, JF ; Lee, EY ; Ke, ZJ ; Lü, J.; Ding, S.; Li, L.; Shelton, BJ ; Tucker, T.; Evers, BM ; Zhang, Z.; Shi, X. "Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway." Toxicology and applied pharmacology 262, 1 (2012): 11-21. [PubMed Link] | [ Full text ]
Gedaly, R.; Angulo, P.; Chen, C.; Creasy, KT ; Spear, BT ; Hundley, J.; Daily, MF ; Shah, M.; Evers, BM "The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment." Anticancer research 32, 7 (2012): 2531-6. [PubMed Link] | [ Full text ]
Yu, T.; Chen, X.; Zhang, W.; Colon, D.; Shi, J.; Napier, D.; Rychahou, P.; Lu, W.; Lee, EY ; Weiss, HL ; Evers, BM ; Liu, C. "Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer." The Journal of biological chemistry 287, 6 (2012): 3760-8. [PubMed Link] | [ Full text ]
Guo, Z.; Zhou, Y.; Evers, BM ; Wang, Q. "Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells." Biochemical and biophysical research communications 418, 2 (2012): 426-32. [PubMed Link] | [ Full text ]
Haque, F.; Shu, D.; Shu, Y ; Shlyakhtenko, LS ; Rychahou, PG ; Evers, BM ; Guo, P. "Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers." Nano today 7, 4 (2012): 245-257. [PubMed Link] |
Valentino, JD ; Elliott, VA ; Zaytseva, YY ; Rychahou, PG ; Mustain, WC ; Wang, C.; Gao, T.; Evers, BM "Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer." Surgery 152, 2 (2012): 277-85. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Cassidy, MG ; Rychahou, P.; Starr, ME ; Liu, J.; Li, X.; Epperly, G.; Weiss, HL ; Townsend CM, Jr ; Gao, T.; Evers, BM "PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport." Molecular endocrinology (Baltimore, Md.) 26, 8 (2012): 1380-93. [PubMed Link] | [ Full text ]
Zhou, Y.; Wang, Q.; Guo, Z.; Weiss, HL ; Evers, BM "Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells." Molecular biology of the cell 23, 15 (2012): 2963-72. [PubMed Link] | [ Full text ]
Gedaly, R.; Angulo, P.; Hundley, J.; Daily, MF ; Chen, C.; Evers, BM "PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation." The Journal of surgical research 176, 2 (2012): 542-8. [PubMed Link] | [ Full text ]
Xiong, G.; Wang, C.; Evers, BM ; Zhou, BP ; Xu, R. "RORα suppresses breast tumor invasion by inducing SEMA3F expression." Cancer research 72, 7 (2012): 1728-39. [PubMed Link] | [ Full text ]
Dong, C.; Wu, Y.; Yao, J.; Wang, Y.; Yu, Y.; Rychahou, PG ; Evers, BM ; Zhou, BP "G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer." The Journal of clinical investigation 122, 4 (2012): 1469-86. [PubMed Link] | [ Full text ]
Takahashi, H.; Okamura, D.; Starr, ME ; Saito, H.; Evers, BM "Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation." Aging cell 11, 2 (2012): 305-14. [PubMed Link] | [ Full text ]
Gulhati, P.; Bowen, KA ; Liu, J.; Stevens, PD ; Rychahou, PG ; Chen, M.; Lee, EY ; Weiss, HL ; O'Connor, KL ; Gao, T.; Evers, BM "mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways." Cancer research 71, 9 (2011): 3246-56. [PubMed Link] | [ Full text ]
Zhang, W.; Sviripa, V.; Kril, LM ; Chen, X.; Yu, T.; Shi, J.; Rychahou, P.; Evers, BM ; Watt, DS ; Liu, C. "Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression." Journal of medicinal chemistry 54, 5 (2011): 1288-97. [PubMed Link] | [ Full text ]
Li, J.; Liu, J.; Song, J.; Wang, X.; Weiss, HL ; Townsend CM, Jr ; Gao, T.; Evers, BM "mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON." American journal of physiology. Cell physiology 301, 1 (2011): C213-26. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Jackson, LN ; Johnson, SM ; Chow, CW ; Evers, BM "Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation." Molecular biology of the cell 22, 3 (2011): 412-20. [PubMed Link] | [ Full text ]
Mustain, WC ; Rychahou, PG ; Evers, BM "The role of neurotensin in physiologic and pathologic processes." Current opinion in endocrinology, diabetes, and obesity 18, 1 (2011): 75-82. [PubMed Link] | [ Full text ]
Silva, SR ; Zaytseva, YY ; Jackson, LN ; Lee, EY ; Weiss, HL ; Bowen, KA ; Townsend CM, Jr ; Evers, BM "The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON." Anticancer research 31, 4 (2011): 1153-60. [PubMed Link] | [ Full text ]
Valentino, J.; Evers, BM "Recent advances in the diagnosis and treatment of gastrointestinal carcinoids." Advances in surgery 45, (2011): 285-300. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Weiss, HL ; Chow, CW ; Evers, BM "NFATc1 regulation of TRAIL expression in human intestinal cells." PloS one 6, 5 (2011): e19882. [PubMed Link] | [ Full text ]
Lin, Y.; Wu, Y.; Li, J.; Dong, C.; Ye, X.; Chi, YI ; Evers, BM ; Zhou, BP "The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1." The EMBO journal 29, 11 (2010): 1803-16. [PubMed Link] | [ Full text ]
Gedaly, R.; Angulo, P.; Hundley, J.; Daily, MF ; Chen, C.; Koch, A.; Evers, BM "PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways." Anticancer research 30, 12 (2010): 4951-8. [PubMed Link] | [ Full text ]
Bowen, KA ; Doan, HQ ; Zhou, BP ; Wang, Q.; Zhou, Y.; Rychahou, PG ; Evers, BM "PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells." Anticancer research 29, 11 (2009): 4439-49. [PubMed Link] | [ Full text ]
Gulhati, P.; Cai, Q.; Li, J.; Liu, J.; Rychahou, PG ; Qiu, S.; Lee, EY ; Silva, SR ; Bowen, KA ; Gao, T.; Evers, BM "Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 15, 23 (2009): 7207-16. [PubMed Link] | [ Full text ]
Evers, BM ; Mullins, RJ ; Matthews, TH ; Broghamer, WL ; Polk HC, Jr "Multiple adenocarcinomas of the colon and rectum. An analysis of incidences and current trends." Diseases of the colon and rectum 31, 7 (1988): 518-22. [PubMed Link] |
Malangoni, MA ; Evers, BM ; Peyton, JC ; Wellhausen, SR "Reticuloendothelial clearance and splenic mononuclear cell populations after resection and autotransplantation." American journal of surgery 155, 2 (1988): 298-302. [PubMed Link] | [ Full text ]