B. Mark Evers, MD, FACS

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About
Education
Publications

mark.evers@uky.edu

Position(s):

Professor of Surgery

Mark McDowell Cancer Foundation Chair in the Lucille P. Markey Cancer Center

Director, Markey Cancer Center

Physician-In-Chief, Oncology Service

Affiliation(s):

Lucille Parker Markey Cancer Center

Surgery

Other Affiliation(s):

Surgery/General

Surgical Oncology

MD/PhD Program Internal Advisory Committee

MD/PhD Program Mentor

Bio / Education:

Medical School
summa cum laude
University of Tennessee, Memphis, TN

Residency
University of Louisville, Louisville, KY

Fellowship - Research
University of Texas Medical Branch, Galveston, TX

Surgical Interests
Gastrointestinal surgery
Oncology

PubMed Publications:

Frohman, H.A.;Rychahou, P.G.;Li, J.;Gan, T.;Evers, B.M. "Development of murine bariatric surgery models: lessons learned." The Journal of surgical research 229, (2018): 302-310. [PubMed Link] | [ Full text ]
Li, J.;Song, J.;Li, X.;Brock, S.;Sinner, H.F.;Weiss, H.L.;Weiss, T.;Townsend CM, J.;Gao, T.;Evers, B.M. "FFAR4 is involved in regulation of neurotensin release from neuroendocrine cells and male C57BL/6 mice." Endocrinology (2018): [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Rychahou, P.;Harris, J.W.;Zaytseva, Y.Y.;Liu, J.;Wang, C.;Weiss, H.L.;Liu, C.;Lee, E.Y.;Evers, B.M. "Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth." Cancer research 78, 12 (2018): 3163-3175. [PubMed Link] | [ Full text ]
Pi, F.;Binzel, D.W.;Lee, T.J.;Li, Z.;Sun, M.;Rychahou, P.;Li, H.;Haque, F.;Wang, S.;Croce, C.M.;Guo, B.;Evers, B.M.;Guo, P. "Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression." Nature nanotechnology 13, 1 (2018): 82-89. [PubMed Link] |
Wen, Y.A.;Xiong, X.;Zaytseva, Y.Y.;Napier, D.L.;Vallee, E.;Li, A.T.;Wang, C.;Weiss, H.L.;Evers, B.M.;Gao, T. "Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer." Cell death & disease 9, 3 (2018): 265. [PubMed Link] | [ Full text ]
Kim, J.T.;Napier, D.L.;Weiss, H.L.;Lee, E.Y.;Townsend CM, J.;Evers, B.M. "Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration." Neoplasia (New York, N.Y.) 20, 2 (2018): 175-181. [PubMed Link] | [ Full text ]
Chauhan, A.;Farooqui, Z.;Murray, L.A.;Weiss, H.L.;War Myint, Z.;Raajasekar, A.K.A.;Evers, B.M.;Arnold, S.;Anthony, L. "Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary." Journal of oncology 2018, (2018): 3519247. [PubMed Link] | [ Full text ]
Lin, Y.;Wang, Y.;Shi, Q.;Yu, Q.;Liu, C.;Feng, J.;Deng, J.;Evers, B.M.;Zhou, B.P.;Wu, Y. "Stabilization of the transcription factors slug and twist by the deubiquitinase dub3 is a key requirement for tumor metastasis." Oncotarget 8, 43 (2017): 75127-75140. [PubMed Link] | [ Full text ]
Mitov, M.I.;Harris, J.W.;Alstott, M.C.;Zaytseva, Y.Y.;Evers, B.M.;Butterfield, D.A. "Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines." Experimental cell research 354, 2 (2017): 112-121. [PubMed Link] | [ Full text ]
Kenlan, D.E.;Rychahou, P.;Sviripa, V.M.;Weiss, H.L.;Liu, C.;Watt, D.S.;Evers, B.M. "Fluorinated N,N'-Diarylureas As Novel Therapeutic Agents Against Cancer Stem Cells." Molecular cancer therapeutics 16, 5 (2017): 831-837. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Rychahou, P.;Fan, T.W.;Lane, A.N.;Weiss, H.L.;Evers, B.M. "Ketogenesis contributes to intestinal cell differentiation." Cell death and differentiation 24, 3 (2017): 458-468. [PubMed Link] | [ Full text ]
Kim, J.T.;Weiss, H.L.;Evers, B.M. "Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells." International journal of oncology 50, 6 (2017): 2200-2206. [PubMed Link] | [ Full text ]
Wu, Y.;Wang, Y.;Lin, Y.;Liu, Y.;Wang, Y.;Jia, J.;Singh, P.;Chi, Y.I.;Wang, C.;Dong, C.;Li, W.;Tao, M.;Napier, D.;Shi, Q.;Deng, J.;Evers, B.M.;Zhou, B.P. "Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation." Nature communications 8, (2017): 14228. [PubMed Link] | [ Full text ]
Wang, J.;Ye, Q.;Cao, Y.;Guo, Y.;Huang, X.;Mi, W.;Liu, S.;Wang, C.;Yang, H.S.;Zhou, B.P.;Evers, B.M.;She, Q.B. "Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1." Nature communications 8, 1 (2017): 2207. [PubMed Link] | [ Full text ]
Gao, T.;Evers, B.M. "Colorectal cancer: A new innate immune sensor - functions from inside the colonic epithelium." Nature reviews. Gastroenterology & hepatology 14, 4 (2017): 199-200. [PubMed Link] | [ Full text ]
Li, J.;Song, J.;Zaytseva, Y.Y.;Liu, Y.;Rychahou, P.;Jiang, K.;Starr, M.E.;Kim, J.T.;Harris, J.W.;Yiannikouris, F.B.;Katz, W.S.;Nilsson, P.M.;Orho-Melander, M.;Chen, J.;Zhu, H.;Fahrenholz, T.;Higashi, R.M.;Gao, T.;Morris, A.J.;Cassis, L.A.;Fan, T.W.;Weiss, H.L.;Dobner, P.R.;Melander, O.;Jia, J.;Evers, B.M. "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
Yu, T.;Chen, X.;Lin, T.;Liu, J.;Li, M.;Zhang, W.;Xu, X.;Zhao, W.;Liu, M.;Napier, D.L.;Wang, C.;Evers, B.M.;Liu, C. "KLF4 deletion alters gastric cell lineage and induces MUC2 expression." Cell death & disease 7, 6 (2016): e2255. [PubMed Link] | [ Full text ]
Upreti, M.;Jyoti, A.;Johnson, S.E.;Swindell, E.P.;Napier, D.;Sethi, P.;Chan, R.;Feddock, J.M.;Weiss, H.L.;O'Halloran, T.V.;Evers, B.M. "Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer." Oncotarget 7, 27 (2016): 41559-41574. [PubMed Link] | [ Full text ]
Li, J.;Song, J.;Weiss, H.L.;Weiss, T.;Townsend CM, J.;Evers, B.M. "Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells." Molecular endocrinology (Baltimore, Md.) 30, 1 (2016): 26-36. [PubMed Link] | [ Full text ]
Jiang, K.;Liu, Y.;Fan, J.;Zhang, J.;Li, X.A.;Evers, B.M.;Zhu, H.;Jia, J. "PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail." PLoS biology 14, 2 (2016): e1002375. [PubMed Link] | [ Full text ]
Vilchez, V.;Turcios, L.;Zaytseva, Y.;Stewart, R.;Lee, E.Y.;Maynard, E.;Shah, M.B.;Daily, M.F.;Tzeng, C.W.;Davenport, D.;Castellanos, A.L.;Krohmer, S.;Hosein, P.J.;Evers, B.M.;Gedaly, R. "Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma." American journal of surgery 212, 2 (2016): 238-45. [PubMed Link] | [ Full text ]
Sharma, A.;Haque, F.;Pi, F.;Shlyakhtenko, L.S.;Evers, B.M.;Guo, P. "Controllable self-assembly of RNA dendrimers." Nanomedicine : nanotechnology, biology, and medicine 12, 3 (2016): 835-844. [PubMed Link] | [ Full text ]
Kim, J.T.;Li, J.;Song, J.;Lee, E.Y.;Weiss, H.L.;Townsend CM, J.;Evers, B.M. "Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells." Oncotarget 6, 29 (2015): 26960-70. [PubMed Link] | [ Full text ]
Wydra, R.J.;Rychahou, P.G.;Evers, B.M.;Anderson, K.W.;Dziubla, T.D.;Hilt, J.Z. "The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity." Acta biomaterialia 25, (2015): 284-90. [PubMed Link] | [ Full text ]
Kim, J.T.;Liu, C.;Zaytseva, Y.Y.;Weiss, H.L.;Townsend CM, J.;Evers, B.M. "Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells." International journal of cancer 136, 6 (2015): 1475-81. [PubMed Link] | [ Full text ]
Starr, M.E.;Takahashi, H.;Okamura, D.;Zwischenberger, B.A.;Mrazek, A.A.;Ueda, J.;Stromberg, A.J.;Evers, B.M.;Esmon, C.T.;Saito, H. "Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis." American journal of physiology. Heart and circulatory physiology 308, 2 (2015): H83-91. [PubMed Link] | [ Full text ]
Zhou, Y.;Rychahou, P.;Wang, Q.;Weiss, H.L.;Evers, B.M. "TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium." Cell death & disease 6, (2015): e1631. [PubMed Link] | [ Full text ]
Rychahou, P.;Haque, F.;Hu, Y.S.;Zaytseva, Y.;Weiss, H.L.;Lee, E.Y.;Mustain, W.;Valentino, J.;Guo, P.;Evers, B.M. "Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration." ACS nano 9, 2 (2015): 1108-16. [PubMed Link] | [ Full text ]
Starr, M.E.;Saito, M.;Evers, B.M.;Saito, H. "Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue." The journals of gerontology. Series A, Biological sciences and medical sciences 70, 12 (2015): 1508-15. [PubMed Link] | [ Full text ]
Zaytseva, Y.Y.;Harris, J.W.;Mitov, M.I.;Kim, J.T.;Butterfield, D.A.;Lee, E.Y.;Weiss, H.L.;Gao, T.;Evers, B.M. "Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration." Oncotarget 6, 22 (2015): 18891-904. [PubMed Link] | [ Full text ]
Li, H.;Rychahou, P.G.;Cui, Z.;Pi, F.;Evers, B.M.;Shu, D.;Guo, P.;Luo, W. "RNA Nanoparticles Derived from Three-Way Junction of Phi29 Motor pRNA Are Resistant to I-125 and Cs-131 Radiation." Nucleic acid therapeutics 25, 4 (2015): 188-97. [PubMed Link] | [ Full text ]
Zhu, J.;Xiong, G.;Fu, H.;Evers, B.M.;Zhou, B.P.;Xu, R. "Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network." Cancer research 75, 8 (2015): 1580-91. [PubMed Link] | [ Full text ]
Evers, B.M. "The evolving role of the surgeon scientist." Journal of the American College of Surgeons 220, 4 (2015): 387-95. [PubMed Link] | [ Full text ]
Rychahou, P.;Hu, Y.S.;Haque, F.;Hu, J.;Guo, P.;Evers, B.M. "Methods and assays for specific targeting and delivery of RNA nanoparticles to cancer metastases." Methods in molecular biology (Clifton, N.J.) 1297, (2015): 121-35. [PubMed Link] | [ Full text ]
Zhou, Y.;Wang, Q.;Weiss, H.L.;Evers, B.M. "Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway." Molecular biology of the cell 25, 18 (2014): 2882-90. [PubMed Link] | [ Full text ]
Bailey, M.B.;Davenport, D.L.;Vargas, H.D.;Evers, B.M.;McKenzie, S.P. "Longer operative time: deterioration of clinical outcomes of laparoscopic colectomy versus open colectomy." Diseases of the colon and rectum 57, 5 (2014): 616-22. [PubMed Link] | [ Full text ]
Valentino, J.D.;Li, J.;Zaytseva, Y.Y.;Mustain, W.C.;Elliott, V.A.;Kim, J.T.;Harris, J.W.;Campbell, K.;Weiss, H.;Wang, C.;Song, J.;Anthony, L.;Townsend CM, J.;Evers, B.M. "Cotargeting the PI3K and RAS pathways for the treatment of neuroendocrine tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 20, 5 (2014): 1212-22. [PubMed Link] | [ Full text ]
Hollis, C.P.;Weiss, H.L.;Evers, B.M.;Gemeinhart, R.A.;Li, T. "In vivo investigation of hybrid Paclitaxel nanocrystals with dual fluorescent probes for cancer theranostics." Pharmaceutical research 31, 6 (2014): 1450-9. [PubMed Link] | [ Full text ]
McKenzie, S.P.;Vargas, H.D.;Evers, B.M.;Davenport, D.L. "Selection criteria for combined resection of synchronous colorectal cancer hepatic metastases: a cautionary note." International journal of colorectal disease 29, 6 (2014): 729-35. [PubMed Link] | [ Full text ]
Zaytseva, Y.Y.;Elliott, V.A.;Rychahou, P.;Mustain, W.C.;Kim, J.T.;Valentino, J.;Gao, T.;O'Connor, K.L.;Neltner, J.M.;Lee, E.Y.;Weiss, H.L.;Evers, B.M. "Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer." Carcinogenesis 35, 6 (2014): 1341-51. [PubMed Link] | [ Full text ]
Shi, J.;Wang, Y.;Zeng, L.;Wu, Y.;Deng, J.;Zhang, Q.;Lin, Y.;Li, J.;Kang, T.;Tao, M.;Rusinova, E.;Zhang, G.;Wang, C.;Zhu, H.;Yao, J.;Zeng, Y.X.;Evers, B.M.;Zhou, M.M.;Zhou, B.P. "Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer." Cancer cell 25, 2 (2014): 210-25. [PubMed Link] | [ Full text ]
Hu, Y.S.;Pi, F.;Sharma, A.;Rajabi, M.;Haque, F.;Shu, D.;Leggas, M.;Evers, B.M.;Guo, P. "Stable RNA nanoparticles as potential new generation drugs for cancer therapy." Advanced drug delivery reviews 66, (2014): 74-89. [PubMed Link] | [ Full text ]
Ye, Q.;Cai, W.;Zheng, Y.;Evers, B.M.;She, Q.B. "ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer." Oncogene 33, 14 (2014): 1828-39. [PubMed Link] | [ Full text ]
Gedaly, R.;Galuppo, R.;Daily, M.F.;Shah, M.;Maynard, E.;Chen, C.;Zhang, X.;Esser, K.A.;Cohen, D.A.;Evers, B.M.;Jiang, J.;Spear, B.T. "Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535." PloS one 9, 6 (2014): e99272. [PubMed Link] | [ Full text ]
Elliott, V.A.;Rychahou, P.;Zaytseva, Y.Y.;Evers, B.M. "Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model." PloS one 9, 5 (2014): e97432. [PubMed Link] | [ Full text ]
Starr, M.E.;Steele, A.M.;Saito, M.;Hacker, B.J.;Evers, B.M.;Saito, H. "A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis." PloS one 9, 12 (2014): e115705. [PubMed Link] | [ Full text ]
Wu, Y.;Wang, Y.;Yang, X.H.;Kang, T.;Zhao, Y.;Wang, C.;Evers, B.M.;Zhou, B.P. "The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells." Cell reports 5, 1 (2013): 224-36. [PubMed Link] | [ Full text ]
Hollis, C.P.;Weiss, H.L.;Leggas, M.;Evers, B.M.;Gemeinhart, R.A.;Li, T. "Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery." Journal of controlled release : official journal of the Controlled Release Society 172, 1 (2013): 12-21. [PubMed Link] | [ Full text ]
Wang, S.;Haque, F.;Rychahou, P.G.;Evers, B.M.;Guo, P. "Engineered nanopore of Phi29 DNA-packaging motor for real-time detection of single colon cancer specific antibody in serum." ACS nano 7, 11 (2013): 9814-22. [PubMed Link] | [ Full text ]
Gedaly, R.;Galuppo, R.;Musgrave, Y.;Angulo, P.;Hundley, J.;Shah, M.;Daily, M.F.;Chen, C.;Cohen, D.A.;Spear, B.T.;Evers, B.M. "PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation." The Journal of surgical research 185, 1 (2013): 225-30. [PubMed Link] | [ Full text ]
Kim, J.T.;Li, J.;Jang, E.R.;Gulhati, P.;Rychahou, P.G.;Napier, D.L.;Wang, C.;Weiss, H.L.;Lee, E.Y.;Anthony, L.;Townsend CM, J.;Liu, C.;Evers, B.M. "Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors." Carcinogenesis 34, 5 (2013): 953-61. [PubMed Link] | [ Full text ]
Dong, C.;Yuan, T.;Wu, Y.;Wang, Y.;Fan, T.W.;Miriyala, S.;Lin, Y.;Yao, J.;Shi, J.;Kang, T.;Lorkiewicz, P.;St Clair, D.;Hung, M.C.;Evers, B.M.;Zhou, B.P. "Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer." Cancer cell 23, 3 (2013): 316-31. [PubMed Link] | [ Full text ]
Dong, C.;Wu, Y.;Wang, Y.;Wang, C.;Kang, T.;Rychahou, P.G.;Chi, Y.I.;Evers, B.M.;Zhou, B.P. "Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer." Oncogene 32, 11 (2013): 1351-62. [PubMed Link] | [ Full text ]
Li, X.;Zhou, Q.;Sunkara, M.;Kutys, M.L.;Wu, Z.;Rychahou, P.;Morris, A.J.;Zhu, H.;Evers, B.M.;Huang, C. "Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration." Journal of cell science 126, Pt 12 (2013): 2617-28. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Rychahou, P.;Liu, C.;Weiss, H.L.;Evers, B.M. "NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation." Cell death & disease 4, (2013): e671. [PubMed Link] | [ Full text ]
Li, X.;Stevens, P.D.;Yang, H.;Gulhati, P.;Wang, W.;Evers, B.M.;Gao, T. "The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer." Oncogene 32, 4 (2013): 471-8. [PubMed Link] | [ Full text ]
Valentino, J.D.;Rychahou, P.G.;Mustain, W.C.;Elliott, V.A.;Evers, B.M. "Murine portal vein catheterization to analyze liver-directed therapies." The Journal of surgical research 185, 2 (2013): 690-6. [PubMed Link] | [ Full text ]
Zhang, W.;Sviripa, V.;Chen, X.;Shi, J.;Yu, T.;Hamza, A.;Ward, N.D.;Kril, L.M.;Vander Kooi, C.W.;Zhan, C.G.;Evers, B.M.;Watt, D.S.;Liu, C. "Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A." ACS chemical biology 8, 4 (2013): 796-803. [PubMed Link] | [ Full text ]
Starr, M.E.;Hu, Y.;Stromberg, A.J.;Carmical, J.R.;Wood, T.G.;Evers, B.M.;Saito, H. "Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors." Aging cell 12, 2 (2013): 194-206. [PubMed Link] | [ Full text ]
Mustain, W.C.;Starr, M.E.;Valentino, J.D.;Cohen, D.A.;Okamura, D.;Wang, C.;Evers, B.M.;Saito, H. "Inflammatory cytokine gene expression in mesenteric adipose tissue during acute experimental colitis." PloS one 8, 12 (2013): e83693. [PubMed Link] | [ Full text ]
Gulhati, P.;Zaytseva, Y.Y.;Valentino, J.D.;Stevens, P.D.;Kim, J.T.;Sasazuki, T.;Shirasawa, S.;Lee, E.Y.;Weiss, H.L.;Dong, J.;Gao, T.;Evers, B.M. "Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA." Carcinogenesis 33, 9 (2012): 1782-90. [PubMed Link] | [ Full text ]
Okamura, D.;Starr, M.E.;Lee, E.Y.;Stromberg, A.J.;Evers, B.M.;Saito, H. "Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis." Aging cell 11, 5 (2012): 760-9. [PubMed Link] | [ Full text ]
Zaytseva, Y.Y.;Rychahou, P.G.;Gulhati, P.;Elliott, V.A.;Mustain, W.C.;O'Connor, K.;Morris, A.J.;Sunkara, M.;Weiss, H.L.;Lee, E.Y.;Evers, B.M. "Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer." Cancer research 72, 6 (2012): 1504-17. [PubMed Link] | [ Full text ]
Zaytseva, Y.Y.;Valentino, J.D.;Gulhati, P.;Evers, B.M. "mTOR inhibitors in cancer therapy." Cancer letters 319, 1 (2012): 1-7. [PubMed Link] | [ Full text ]
Wang, X.;Mandal, A.K.;Saito, H.;Pulliam, J.F.;Lee, E.Y.;Ke, Z.J.;Lu, J.;Ding, S.;Li, L.;Shelton, B.J.;Tucker, T.;Evers, B.M.;Zhang, Z.;Shi, X. "Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway." Toxicology and applied pharmacology 262, 1 (2012): 11-21. [PubMed Link] | [ Full text ]
Gedaly, R.;Angulo, P.;Chen, C.;Creasy, K.T.;Spear, B.T.;Hundley, J.;Daily, M.F.;Shah, M.;Evers, B.M. "The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment." Anticancer research 32, 7 (2012): 2531-6. [PubMed Link] | [ Full text ]
Yu, T.;Chen, X.;Zhang, W.;Colon, D.;Shi, J.;Napier, D.;Rychahou, P.;Lu, W.;Lee, E.Y.;Weiss, H.L.;Evers, B.M.;Liu, C. "Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer." The Journal of biological chemistry 287, 6 (2012): 3760-8. [PubMed Link] | [ Full text ]
Guo, Z.;Zhou, Y.;Evers, B.M.;Wang, Q. "Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells." Biochemical and biophysical research communications 418, 2 (2012): 426-32. [PubMed Link] | [ Full text ]
Haque, F.;Shu, D.;Hu, Y.S.;Shlyakhtenko, L.S.;Rychahou, P.G.;Evers, B.M.;Guo, P. "Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers." Nano today 7, 4 (2012): 245-257. [PubMed Link] |
Valentino, J.D.;Elliott, V.A.;Zaytseva, Y.Y.;Rychahou, P.G.;Mustain, W.C.;Wang, C.;Gao, T.;Evers, B.M. "Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer." Surgery 152, 2 (2012): 277-85. [PubMed Link] | [ Full text ]
Li, J.;Song, J.;Cassidy, M.G.;Rychahou, P.;Starr, M.E.;Liu, J.;Li, X.;Epperly, G.;Weiss, H.L.;Townsend CM, J.;Gao, T.;Evers, B.M. "PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport." Molecular endocrinology (Baltimore, Md.) 26, 8 (2012): 1380-93. [PubMed Link] | [ Full text ]
Zhou, Y.;Wang, Q.;Guo, Z.;Weiss, H.L.;Evers, B.M. "Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells." Molecular biology of the cell 23, 15 (2012): 2963-72. [PubMed Link] | [ Full text ]
Gedaly, R.;Angulo, P.;Hundley, J.;Daily, M.F.;Chen, C.;Evers, B.M. "PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation." The Journal of surgical research 176, 2 (2012): 542-8. [PubMed Link] | [ Full text ]
Xiong, G.;Wang, C.;Evers, B.M.;Zhou, B.P.;Xu, R. "RORα suppresses breast tumor invasion by inducing SEMA3F expression." Cancer research 72, 7 (2012): 1728-39. [PubMed Link] | [ Full text ]
Dong, C.;Wu, Y.;Yao, J.;Wang, Y.;Yu, Y.;Rychahou, P.G.;Evers, B.M.;Zhou, B.P. "G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer." The Journal of clinical investigation 122, 4 (2012): 1469-86. [PubMed Link] | [ Full text ]
Takahashi, H.;Okamura, D.;Starr, M.E.;Saito, H.;Evers, B.M. "Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation." Aging cell 11, 2 (2012): 305-14. [PubMed Link] | [ Full text ]
Gulhati, P.;Bowen, K.A.;Liu, J.;Stevens, P.D.;Rychahou, P.G.;Chen, M.;Lee, E.Y.;Weiss, H.L.;O'Connor, K.L.;Gao, T.;Evers, B.M. "mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways." Cancer research 71, 9 (2011): 3246-56. [PubMed Link] | [ Full text ]
Zhang, W.;Sviripa, V.;Kril, L.M.;Chen, X.;Yu, T.;Shi, J.;Rychahou, P.;Evers, B.M.;Watt, D.S.;Liu, C. "Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression." Journal of medicinal chemistry 54, 5 (2011): 1288-97. [PubMed Link] | [ Full text ]
Li, J.;Liu, J.;Song, J.;Wang, X.;Weiss, H.L.;Townsend CM, J.;Gao, T.;Evers, B.M. "mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON." American journal of physiology. Cell physiology 301, 1 (2011): C213-26. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Jackson, L.N.;Johnson, S.M.;Chow, C.W.;Evers, B.M. "Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation." Molecular biology of the cell 22, 3 (2011): 412-20. [PubMed Link] | [ Full text ]
Mustain, W.C.;Rychahou, P.G.;Evers, B.M. "The role of neurotensin in physiologic and pathologic processes." Current opinion in endocrinology, diabetes, and obesity 18, 1 (2011): 75-82. [PubMed Link] | [ Full text ]
Silva, S.R.;Zaytseva, Y.Y.;Jackson, L.N.;Lee, E.Y.;Weiss, H.L.;Bowen, K.A.;Townsend CM, J.;Evers, B.M. "The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON." Anticancer research 31, 4 (2011): 1153-60. [PubMed Link] | [ Full text ]
Valentino, J.;Evers, B.M. "Recent advances in the diagnosis and treatment of gastrointestinal carcinoids." Advances in surgery 45, (2011): 285-300. [PubMed Link] | [ Full text ]
Wang, Q.;Zhou, Y.;Weiss, H.L.;Chow, C.W.;Evers, B.M. "NFATc1 regulation of TRAIL expression in human intestinal cells." PloS one 6, 5 (2011): e19882. [PubMed Link] | [ Full text ]
Lin, Y.;Wu, Y.;Li, J.;Dong, C.;Ye, X.;Chi, Y.I.;Evers, B.M.;Zhou, B.P. "The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1." The EMBO journal 29, 11 (2010): 1803-16. [PubMed Link] | [ Full text ]
Gedaly, R.;Angulo, P.;Hundley, J.;Daily, M.F.;Chen, C.;Koch, A.;Evers, B.M. "PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways." Anticancer research 30, 12 (2010): 4951-8. [PubMed Link] | [ Full text ]
Bowen, K.A.;Doan, H.Q.;Zhou, B.P.;Wang, Q.;Zhou, Y.;Rychahou, P.G.;Evers, B.M. "PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells." Anticancer research 29, 11 (2009): 4439-49. [PubMed Link] | [ Full text ]
Gulhati, P.;Cai, Q.;Li, J.;Liu, J.;Rychahou, P.G.;Qiu, S.;Lee, E.Y.;Silva, S.R.;Bowen, K.A.;Gao, T.;Evers, B.M. "Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 15, 23 (2009): 7207-16. [PubMed Link] | [ Full text ]
Evers, B.M.;Mullins, R.J.;Matthews, T.H.;Broghamer, W.L.;Polk HC, J. "Multiple adenocarcinomas of the colon and rectum. An analysis of incidences and current trends." Diseases of the colon and rectum 31, 7 (1988): 518-22. [PubMed Link] |
Malangoni, M.A.;Evers, B.M.;Peyton, J.C.;Wellhausen, S.R. "Reticuloendothelial clearance and splenic mononuclear cell populations after resection and autotransplantation." American journal of surgery 155, 2 (1988): 298-302. [PubMed Link] | [ Full text ]