- BBSRB B355, 741 S Limestone St, Lexington, KY 40536-0509
The long-term goal of the research in my laboratory is to understand the role of platelets in cardiovascular diseases and the underlying molecular mechanisms, which will be used to treat human diseases. To achieve the goal, we mainly focus on exploring the signal transduction during platelets activation under physiological and pathophysiological conditions using cellular, molecular, and genetic approaches.
Ongoing Research Support.
1. GRA Scientist Development Grant AHA Xiang (PI) 07/01/2014-06/30/2017
The role of platelets in sepsis and systemic inflammation
The objective of this proposal is to investigate the role of platelets in sepsis and systemic inflammation, and to explore molecular mechanisms by which platelets affect outcomes of septic shock.
2. Grant-in-Aid AHA Li (PI) 07/01/2014-06/30/2016
Title: Natriuretic peptides ANP and BNP potentiate thrombosis via their receptor NPRA
The objective of this proposal is to investigate the role of the NPs/NPRA/cGMP/PKG pathway in platelet activation, thrombosis, and acute coronary syndromes.
Completed Research Support
1. Postdoctoral Fellowship AHA Xiang (PI) 07/01/2011-06/30/2013
cGMP regulates platelets activation
The objective of this proposal is to identify the function of the key element of the cGMP signaling in platelets, the guanylyl cyclases (GCs), in regulating platelet activation and in vivo thrombosis and hemostasis.
A list of most publications (excluding book chapters ) is available at My Bibliography: