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Charles Coomer
caco269's picture
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charles.coomer@uky.edu
PDF icon Charles Coomer CV_Feb_2018.pdf
@chadd92
Interests / Specialties: 
Virus-Host Interaction
HIV/AIDS
Fluorescence Microscopy
Bio / Education: 

University of Oxford (2017-2021, anticipated)

University College London (2014-2015)
MSc Infection and Immunity

Western Kentucky University (2010-2014)
BA Biology; BA Chemistry

Mentor: 
Alex Compton (NCI/NIH); Sergi Padilla-Parra (University of Oxford)
Research Description: 

My dissertation project underscores the intersection between cell-intrinsic immunity, virus fusion and the biophysical properties which regulate this process using biochemical and quantitative microscopy approaches.

Grants: 

National Institutes of Health Intramural AIDS Research Fellow, 2020-2021

Fellowship in Research Excellence Award, 2019-2020

NIH Oxford-Cambridge Scholars Program Microgrant, 2019

Selected Publications: 

C. Coomer, K. Rahman, A. Compton (2020). The CD225 proteins: a family portrait of fusion regulators. Accepted to Trends in Genetics.

K. Rahman*, C. Coomer*, S. Majdoul, S. Ding, S. Lockett, S. Padilla-Parra, A. Compton (2020). A conserved motif functionally links the antiviral activity of IFITM3 with its oligomeric state in membranes. eLife. 9:e58537 DOI: 10.7554/eLife.58537

C. Coomer, I. Carlon-Andres, M. Iliopoulou, M. Dustin, E. Compeer, A. Compton, S. Padilla-Parra (2020). Single-cell glycolytic activity regulates membrane tension and HIV-1 fusion. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1008359

C. Coomer and S. Padilla-Parra (2020). Towards quantitative imaging of HIV-1 transmission in tissue. Submitted to Encyclopedia of Virology.

M. Iliopoulou, R. Nolan, L. Alvarez, Y. Watanabe, C. Coomer, et al (2018). A dynamic three step mechanism drives the HIV-1 prefusion reaction. Nature Structural and Molecular Biology. https://doi.org/10.1038/s41594-018-0113-x.

Kearney, M.F., Anderson, E.M., Coomer, C., Smith, L., Shao, W., Johnson, N., Kline, C., Spindler, J., Mellors, J.W., Coffin, J.M., and Ambrose, Z. (2015) Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy. Retrovirology 12: 93.

Pope, W.H., et al (2015). Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. eLife; 4: e06416

M.F. Kearney; L. Smith; C. Coomer; G.J. Besson; J. Spindler; E.M. Anderson; W. Shao; T. Tanzosh; C. Rehm; J.W. Mellors; J.M. Coffin; F. Maldarelli. No Evidence for Evolution of Plasma HIV-1 RNA or PBMC HIV-1 DNA During Long-Term Suppressive Antiretroviral Therapy. In preparation for PLoS Pathogens.

Hatfull, G.F., et al (2012). Complete Genome Sequences of 138 Mycobacteriophages. Journal of Virology. 86: 2382-2384

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