Edward J Pavlik

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epaul1@uky.edu

859-323-3830

375 Whitney Hendrickson Bldg

Ovarian Screening Program

Position(s):

Research Faculty

Professor

Director, Ovarian Screening Research Program & Gyn Oncology Research http://ovarianscreening.info

Organizing Editor: In The Know, GYN ONC Literature of Significance (https://igcs.org/in-the-know/)

Affiliation(s):

Obstetrics & Gynecology

Other Affiliation(s):

Gynecologic Oncology

Bio / Education:

Dr. Pavlik is a graduate of the University of Denver, and received his PhD from the University of Tennessee, Knoxville. He received a NCI Public Health Service Fellowship at the University of Illinois, Champaign-Urbana, Illinois and was a Visiting Assistant Professor, Department of Physiology and Biophysics at the University of Illinois, Champaign-Urbana. He is an active lecturer in the College of Medicine and organizes and mentors summer intern research including students from Denison University, Penn State University, Transylvania University, Centre College, Vassar College, the University of North Carolina, Eastern Kentucky University, Depauw University, Union College and the University of Kentucky. He is a member of the Graduate College and serves on dissertation committees for the PhD degree. Dr. Pavlik is an author on over 100 peer reviewed publications, has presented at a number of prestigious international conferences, and has been funded by the NCI, the ACS and the VA. His research focus is on ovarian cancer screening and factors that affect screening accuracy and performance. Dr. Pavlik is a member of the editorial board for: the British Journal of Medicine and Medical Research, Journal of Gynecology and Obstetrics, the Journal of Medical Oncology, the Imaging Journal of Clinical and Medical Sciences, Gynecology and Obstetrics Research, Journal of Cancer Metastasis and Treatment, Women's Health International, Clinics in Oncology- Gynecological Cancers.

More details

International interview

Conversation on Screening

Video on ovarian abnormalities

Dr. Pavlik lectures on breast, colorectal, prostate, cervical and ovarian cancer screening in PHA/MI/MED616, Biology and Therapy of Cancer (3 lecture hrs; 3-6 credits as approved for individual departments). These lectures give a snapshot view of various screening approaches for different cancers and provide greater educational depth to trainees in nanotechnology methods of application.

Dr. Pavlik prepares and distributes In The Know, a monthly compilation of the latest significant literature in Gynecologic Oncology for the GYN ONC fellows which also gets distributed nationally and internationally. Requests to be on the email list to receive In The Know can be sent to him at epaul1@uky.edu

http://statcounter.com/drupal/http://c.statcounter.com/9665628/0/833c4b7f/1/

Selected Publications:

Publications

Research
The University of Kentucky Ovarian Screening Program provides the base for research by Gynecologic Oncology fellows, for Ob/GYN residents, for Summer Undergraduate Interns and for second year Medical Students taking Dr. Pavlik’s College of Medicine elective (OBG 825 001, Obstetrics & Gynecology Elective: Ovarian Cancer Research (3 credit hrs).
The University of Kentucky's Ovarian Screening Program is the largest and longest operating ovarian screening program in the United States. It has been in continuous operation since 1987. It is conducting the only ovarian cancer screening trial in the six states contiguous with Kentucky (Tennessee, Ohio, Illinois, Indiana, West Virginia and Virginia). During the years 1987-2019, 48000+ women have received at least one TVS sonographic screening test with a total of over 320,000 free screens given. About 100+ new particpants join the screening program each month and ~15,000 screens are given annually. In February 2003, The University of Kentucky Ovarian Screening Program began an Outreach Effort that offers screening in Health Departments in Maysville, Prestonsburg, Elizabethtown, Paducah, and Somerset. Women from all 120 Kentucky counties participate in the screening program.

Current Research Goals of the Screening Program:

To prospectively evaluate the false positive (FP) rate of the screening algorithm for distinguishing benign ovarian structures from ovarian malignancies.
To assess the degree to which serial transvaginal ultrasonography identifies the fallopian tubes and changes in size and structure of the fallopian tubes.
To assess the degree to which serial transvaginal ultrasonography revises a single ultrasound by comparisons of subsequent ultrasonography to the initial abnormal sonography and defining the rate of resolution.
To assess the effect of serial transvaginal ultrasonography on the discovery of early stage disease regionally and state-wide and to determine if improvements in disease specific mortality occur as evidenced by lower deaths due to ovarian cancer in regions where screening participation is highest.
To assess the cost-effectiveness of ovarian screening and to examine risk of medical complications arising in the screening program.
To examine perceptions of well-being due to participation in ovarian cancer screening.
To determine the co-factors that contribute to successful annual ultrasound screening for ovarian cancer in a asymptomatic population.
To assess the expression & molecular signatures of STIC (serous tubal intraepithelial carcinoma) in serous carcinomas of the ovary, fallopian tube and endometrium.

PubMed Publications:

Smith, CG ; Sharma, D.; Smith, H ; Zippay, S ; Bastin, L ; Acosta-Briceno, LF ; Lee, JT ; Shelton, BJ ; Gorski, J.; McDowell, A ; Burgess, BT ; Fredericks, TI ; Miller, RW ; Desimone, CP ; Dietrich CS, 3rd ; Gallion, HH ; Ueland, FR ; Pavlik, EJ ; , ; Baldwin, LA "Clinicopathological effects of body composition measurements for patients with endometrial cancer." Minerva ginecologica (2020): [PubMed Link] | [ Full text ]
Gorski, JW ; Quattrone, M ; Van Nagell, JR ; Pavlik, EJ "Assessing the Costs of Screening for Ovarian Cancer in the United States: An Evolving Analysis." Diagnostics (Basel, Switzerland) 10, 2 (2020): [PubMed Link] | [ Full text ]
Pavlik, EJ ; Smith, C.; Dennis, TS ; Harvey, E ; Huang, B.; Chen, Q.; Piecoro, DW ; Burgess, BT ; McDowell, A ; Gorski, J.; Baldwin, LA ; Miller, RW ; Desimone, CP ; C, 3rd Dietrich; Gallion, HH ; Ueland, FR ; Nagell JR, Jr "Disease-Specific Survival of Type I and Type II Epithelial Ovarian Cancers-Stage Challenges Categorical Assignments of Indolence & Aggressiveness." Diagnostics (Basel, Switzerland) 10, 2 (2020): [PubMed Link] | [ Full text ]
Wiggins, AT ; Pavlik, EJ ; Andrykowski, MA "Psychological Response to a False Positive Ovarian Cancer Screening Test Result: Distinct Distress Trajectories and Their Associated Characteristics." Diagnostics (Basel, Switzerland) 9, 4 (2019): [PubMed Link] | [ Full text ]
Levine, D.; Patel, MD ; Suh-Burgmann, EJ ; Andreotti, RF ; Benacerraf, BR ; Benson, CB ; Brewster, WR ; Coleman, BG ; Doubilet, PM ; Goldstein, SR ; Hamper, UM ; Hecht, JL ; Horrow, MM ; Hur, HC ; Marnach, ML ; Pavlík, E.; Platt, LD ; Puscheck, E ; Smith-Bindman, R ; Brown, DL "Simple Adnexal Cysts: SRU Consensus Conference Update on Follow-up and Reporting." Radiology 293, 2 (2019): 359-371. [PubMed Link] | [ Full text ]
Smith, CG ; Davenport, DL ; Gorski, J.; McDowell, A ; Burgess, BT ; Fredericks, TI ; Baldwin, LA ; Miller, RW ; Desimone, CP ; Dietrich CS, 3rd ; Gallion, HH ; Pavlik, EJ ; Nagell JR, Jr ; Ueland, FR "Clinical Factors Associated with Longer Hospital Stay Following Ovarian Cancer Surgery." Healthcare (Basel, Switzerland) 7, 3 (2019): [PubMed Link] | [ Full text ]
Nagell JR, Jr ; Burgess, BT ; Miller, RW ; Baldwin, L.; Desimone, CP ; Ueland, FR ; Huang, B.; Chen, Q.; Kryscio, RJ ; Pavlik, EJ "Survival of Women With Type I and II Epithelial Ovarian Cancer Detected by Ultrasound Screening." Obstetrics and gynecology 132, 5 (2018): 1091-1100. [PubMed Link] | [ Full text ]
Wiggins, AT ; Pavlik, EJ ; Andrykowski, MA "Demographic, clinical, dispositional, and social-environmental characteristics associated with psychological response to a false positive ovarian cancer screening test: a longitudinal study." Journal of behavioral medicine 41, 3 (2018): 277-288. [PubMed Link] | [ Full text ]
Wiggins, AT ; Pavlik, EJ ; Andrykowski, MA "Affective, cognitive and behavioral outcomes associated with a false positive ovarian cancer screening test result." Journal of behavioral medicine 40, 5 (2017): 803-813. [PubMed Link] | [ Full text ]
Glanc, P.; Benacerraf, B.; Bourne, T.; Brown, D.; Coleman, BG ; Crum, C.; Dodge, J.; Levine, D.; Pavlík, E.; Timmerman, D.; Ueland, FR ; Wolfman, W.; Goldstein, SR "First International Consensus Report on Adnexal Masses: Management Recommendations." Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 36, 5 (2017): 849-863. [PubMed Link] | [ Full text ]
Baldwin, LA ; Pavlik, EJ ; Ueland, E.; Brown, HE ; Ladd, KM ; Huang, B.; Desimone, CP ; Van Nagell, JR ; Ueland, FR ; Miller, RW "Complications from Surgeries Related to Ovarian Cancer Screening." Diagnostics (Basel, Switzerland) 7, 1 (2017): [PubMed Link] | [ Full text ]
Oré, RM ; Baldwin, L.; Woolum, D.; Elliott, E.; Wijers, C.; Chen, CY ; Miller, RW ; Desimone, CP ; Ueland, FR ; Kryscio, RJ ; Nagell, JR ; Pavlik, EJ "Symptoms Relevant to Surveillance for Ovarian Cancer." Diagnostics (Basel, Switzerland) 7, 1 (2017): [PubMed Link] | [ Full text ]
Pavlik, EJ "Ovarian Cancer Screening: Lessons about Effectiveness." Diagnostics (Basel, Switzerland) 8, 1 (2017): [PubMed Link] | [ Full text ]
Ormsby, EL ; Pavlik, EJ ; McGahan, JP "Ultrasound Monitoring of Extant Adnexal Masses in the Era of Type 1 and Type 2 Ovarian Cancers: Lessons Learned From Ovarian Cancer Screening Trials." Diagnostics (Basel, Switzerland) 7, 2 (2017): [PubMed Link] | [ Full text ]
Pavlik, EJ "Ten Important Considerations for Ovarian Cancer Screening." Diagnostics (Basel, Switzerland) 7, 2 (2017): [PubMed Link] | [ Full text ]
Pavlik, EJ "Ovarian cancer screening effectiveness: A realization from the UK Collaborative Trial of Ovarian Cancer Screening." Women's health (London, England) 12, 5 (2016): 475-479. [PubMed Link] | [ Full text ]
Lefringhouse, JR ; Neward, E.; Ueland, FR ; Baldwin, LA ; Miller, RW ; Desimone, CP ; Kryscio, RJ ; Van Nagell, JR ; Pavlik, EJ "Probability of fallopian tube and ovarian detection with transvaginal ultrasonography in normal women." Women's health (London, England) 12, 3 (2016): 303-11. [PubMed Link] | [ Full text ]
Ormsby, EL ; Pavlik, EJ ; Van Nagell, JR "Ultrasound follow up of an adnexal mass has the potential to save lives." American journal of obstetrics and gynecology 213, 5 (2015): 657-61, 657.e1. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Ore, R.; Toyama, A.; Woolum, D.; Pavlik, TE ; Baldwin, L. "First year participation in the affordable care act: costs and accessibility to gynecologic oncology." Women's health (London, England) 11, 6 (2015): 865-82. [PubMed Link] | [ Full text ]
Elder, JW ; Pavlik, EJ ; Long, A.; Miller, RW ; Desimone, CP ; Hoff, JT ; Ueland, WR ; Kryscio, RJ ; Nagell JR, Jr ; Ueland, FR "Serial ultrasonographic evaluation of ovarian abnormalities with a morphology index." Gynecologic oncology 135, 1 (2014): 8-12. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Hoff, J.; Woolum, D.; Liang, Y.; Wijers, C.; Schwartz, M.; Lefringhouse, J.; Baldwin, L. "Metrics of the gynecologic oncology literature focused on cited utilization and costs." Gynecologic oncology 132, 2 (2014): 423-7. [PubMed Link] | [ Full text ]
Hoff, J.; Baldwin, L.; Lefringhouse, J.; Pavlík, E.; Miller, R.; DeSimone, C ; Ueland, F.; Tucker, T.; Kryscio, R.; Van Nagell, JR "Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer." Journal of oncology 2014, (2014): 312193. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Nagell JR, Jr "Early detection of ovarian tumors using ultrasound." Women's health (London, England) 9, 1 (2013): 39-55; quiz 56-7. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Ueland, FR ; Miller, RW ; Ubellacker, JM ; Desimone, CP ; Elder, J.; Hoff, J.; Baldwin, L.; Kryscio, RJ ; Nagell JR, Jr "Frequency and disposition of ovarian abnormalities followed with serial transvaginal ultrasonography." Obstetrics and gynecology 122, 2 Pt 1 (2013): 210-7. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Nagell JR, Jr "Ovarian cancer screening--what women want." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 22 Suppl 1, (2012): S21-3. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; Pavlik, EJ "Ovarian cancer screening." Clinical obstetrics and gynecology 55, 1 (2012): 43-51. [PubMed Link] | [ Full text ]
Floyd, A.; Steffens, RF ; Pavlík, E.; Andrykowski, MA "Receipt of a false positive test result during routine screening for ovarian cancer: a teachable moment?" Journal of clinical psychology in medical settings 18, 1 (2011): 70-7. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; Miller, RW ; Desimone, CP ; Ueland, FR ; Podzielinski, I.; Goodrich, ST ; Elder, JW ; Huang, B.; Kryscio, RJ ; Pavlik, EJ "Long-term survival of women with epithelial ovarian cancer detected by ultrasonographic screening." Obstetrics and gynecology 118, 6 (2011): 1212-21. [PubMed Link] | [ Full text ]
Andrykowski, MA ; Pavlik, EJ "Response to an abnormal ovarian cancer-screening test result: test of the social cognitive processing and cognitive social health information processing models." Psychology & health 26, 4 (2011): 383-97. [PubMed Link] |
Saunders, BA ; Podzielinski, I.; Ware, RA ; Goodrich, S.; Desimone, CP ; Ueland, FR ; Seamon, L.; Ubellacker, J.; Pavlik, EJ ; Kryscio, RJ ; Nagell JR, Jr "Risk of malignancy in sonographically confirmed septated cystic ovarian tumors." Gynecologic oncology 118, 3 (2010): 278-82. [PubMed Link] | [ Full text ]
McDonald, JM ; Doran, S.; Desimone, CP ; Ueland, FR ; DePriest, PD ; Ware, RA ; Saunders, BA ; Pavlik, EJ ; Goodrich, S.; Kryscio, RJ ; Nagell JR, Jr "Predicting risk of malignancy in adnexal masses." Obstetrics and gynecology 115, 4 (2010): 687-94. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Saunders, BA ; Doran, S.; McHugh, KW ; Ueland, FR ; Desimone, CP ; DePriest, PD ; Ware, RA ; Kryscio, RJ ; Nagell JR, Jr "The search for meaning-Symptoms and transvaginal sonography screening for ovarian cancer: predicting malignancy." Cancer 115, 16 (2009): 3689-98. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; DePriest, PD ; Ueland, FR ; Desimone, CP ; Cooper, AL ; McDonald, JM ; Pavlik, EJ ; Kryscio, RJ "Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened." Cancer 109, 9 (2007): 1887-96. [PubMed Link] | [ Full text ]
Lykins, EL ; Pavlik, EL ; Andrykowski, MA "Validity of self-reports of return for routine repeat screening in an ovarian cancer screening program." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 16, 3 (2007): 490-3. [PubMed Link] | [ Full text ]
Andrykowski, MA ; Zhang, M.; Pavlik, EJ ; Kryscio, RJ "Factors associated with return for routine annual screening in an ovarian cancer screening program." Gynecologic oncology 104, 3 (2007): 695-701. [PubMed Link] | [ Full text ]
Dietrich CS, 3rd ; Desimone, CP ; Modesitt, SC ; DePriest, PD ; Ueland, FR ; Pavlik, EJ ; Kryscio, R.; Cibull, M.; Huh, W.; Partridge, E.; Numnum, TM ; Schilder, J.; Higgins, RV ; Nagell JR, 2nd "Primary appendiceal cancer: gynecologic manifestations and treatment options." Gynecologic oncology 104, 3 (2007): 602-6. [PubMed Link] | [ Full text ]
Desimone, CP ; Van Ness, JS ; Cooper, AL ; Modesitt, SC ; DePriest, PD ; Ueland, FR ; Pavlik, EJ ; Kryscio, RJ ; Nagell JR, Jr "The treatment of lateral T1 and T2 squamous cell carcinomas of the vulva confined to the labium majus or minus." Gynecologic oncology 104, 2 (2007): 390-5. [PubMed Link] | [ Full text ]
Ryan, PY ; Graves, KD ; Pavlik, EJ ; Andrykowski, MA "Abnormal ovarian cancer screening test result: women's informational, psychological and practical needs." Journal of psychosocial oncology 25, 4 (2007): 1-18. [PubMed Link] |
Gaugler, JE ; Pavlík, E.; Salsman, JM ; Andrykowski, MA "Psychological and behavioral impact of receipt of a "normal" ovarian cancer screening test." Preventive medicine 42, 6 (2006): 463-70. [PubMed Link] | [ Full text ]
Ueland, FR ; DePriest, PD ; Desimone, CP ; Pavlik, EJ ; Lele, SM ; Kryscio, RJ ; Nagell JR, Jr "The accuracy of examination under anesthesia and transvaginal sonography in evaluating ovarian size." Gynecologic oncology 99, 2 (2005): 400-3. [PubMed Link] | [ Full text ]
Dietrich CS, 3rd ; Modesitt, SC ; DePriest, PD ; Ueland, FR ; Wilder, J.; Reedy, MB ; Pavlik, EJ ; Kryscio, R.; Cibull, M.; Giesler, J.; Manahan, K.; Huh, W.; Cohn, D.; Powell, M.; Slomovitz, B.; Higgins, RV ; Merritt, W.; Hunter, J.; Puls, L.; Gehrig, P.; Nagell JR, Jr "The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC)." Gynecologic oncology 99, 3 (2005): 557-63. [PubMed Link] | [ Full text ]
Andrykowski, MA ; Boerner, LM ; Salsman, JM ; Pavlík, E. "Psychological response to test results in an ovarian cancer screening program: a prospective, longitudinal study." Health psychology : official journal of the Division of Health Psychology, American Psychological Association 23, 6 (2004): 622-30. [PubMed Link] | [ Full text ]
Salsman, JM ; Pavlík, E.; Boerner, LM ; Andrykowski, MA "Clinical, demographic, and psychological characteristics of new, asymptomatic participants in a transvaginal ultrasound screening program for ovarian cancer." Preventive medicine 39, 2 (2004): 315-22. [PubMed Link] | [ Full text ]
Modesitt, SC ; Pavlik, EJ ; Ueland, FR ; DePriest, PD ; Kryscio, RJ ; Nagell JR, Jr "Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter." Obstetrics and gynecology 102, 3 (2003): 594-9. [PubMed Link] |
Ueland, FR ; DePriest, PD ; Pavlik, EJ ; Kryscio, RJ ; Nagell JR, Jr "Preoperative differentiation of malignant from benign ovarian tumors: the efficacy of morphology indexing and Doppler flow sonography." Gynecologic oncology 91, 1 (2003): 46-50. [PubMed Link] | [ Full text ]
Wilder, JL ; Pavlík, E.; Straughn, JM ; Kirby, T.; Higgins, RV ; DePriest, PD ; Ueland, FR ; Kryscio, RJ ; Whitley, RJ ; Nagell, Jv "Clinical implications of a rising serum CA-125 within the normal range in patients with epithelial ovarian cancer: a preliminary investigation." Gynecologic oncology 89, 2 (2003): 233-5. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Liu, C.; DePriest, PD ; Gallion, HH ; Ueland, FR ; Kryscio, RJ ; Nagell JR, Jr "Relating ovarian size to age, menopausal status, and use of hormones." Gynecologic oncology 80, 2 (2001): 333-4. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Johnson TL, 2nd ; DePriest, PD ; Andrykowski, MA ; Kryscio, RJ ; Nagell JR, Jr "Continuing participation supports ultrasound screening for ovarian cancer." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 15, 5 (2000): 354-64. [PubMed Link] | [ Full text ]
Pavlik, EJ ; DePriest, PD ; Gallion, HH ; Ueland, FR ; Reedy, MB ; Kryscio, RJ ; Nagell JR, Jr "Ovarian volume related to age." Gynecologic oncology 77, 3 (2000): 410-2. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; DePriest, PD ; Reedy, MB ; Gallion, HH ; Ueland, FR ; Pavlik, EJ ; Kryscio, RJ "The efficacy of transvaginal sonographic screening in asymptomatic women at risk for ovarian cancer." Gynecologic oncology 77, 3 (2000): 350-6. [PubMed Link] | [ Full text ]
DePriest, PD ; Gallion, HH ; Pavlik, EJ ; Kryscio, RJ ; Nagell JR, Jr "Transvaginal sonography as a screening method for the detection of early ovarian cancer." Gynecologic oncology 65, 3 (1997): 408-14. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Nelson, K.; DePriest, PD "Publication-quality labeling of gels using transparency-mounted photographs and word processing software." BioTechniques 21, 6 (1996): 1126-7. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; Gallion, HH ; Pavlik, EJ ; DePriest, PD "Ovarian cancer screening." Cancer 76, 10 Suppl (1995): 2086-91. [PubMed Link] |
Pavlik, EJ ; Nagell JR, Jr ; DePriest, PD ; Wheeler, L.; Tatman, JM ; Boone, M.; Sollars, S.; Rayens, MK ; Kryscio, RK "Participation in transvaginal ovarian cancer screening: compliance, correlation factors, and costs." Gynecologic oncology 57, 3 (1995): 395-400. [PubMed Link] | [ Full text ]
DePriest, PD ; Shenson, D.; Fried, A.; Hunter, JE ; Andrews, SJ ; Gallion, HH ; Pavlik, EJ ; Kryscio, RJ ; Nagell JR, Jr "A morphology index based on sonographic findings in ovarian cancer." Gynecologic oncology 51, 1 (1993): 7-11. [PubMed Link] | [ Full text ]
DePriest, PD ; Nagell JR, Jr ; Gallion, HH ; Shenson, D.; Hunter, JE ; Andrews, SJ ; Powell, DE ; Pavlik, EJ "Ovarian cancer screening in asymptomatic postmenopausal women." Gynecologic oncology 51, 2 (1993): 205-9. [PubMed Link] | [ Full text ]
Puls, LE ; Davey, DD ; DePriest, PD ; Gallion, HH ; Nagell JR, Jr ; Hunter, JE ; Pavlik, EJ "Immunohistochemical staining for CA-125 in fallopian tube carcinomas." Gynecologic oncology 48, 3 (1993): 360-3. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; DePriest, PD ; Gallion, HH ; Pavlik, EJ "Ovarian cancer screening." Cancer 71, 4 Suppl (1993): 1523-8. [PubMed Link] |
Kenady, DE ; Pavlik, EJ ; Nelson, K.; Van Nagell, JR ; Gallion, H.; DePriest, PD ; Ryo, UY ; Baranczuk, RJ "Images of estrogen-receptor-positive breast tumors produced by estradiol labeled with iodine I 123 at 16 alpha." Archives of surgery (Chicago, Ill. : 1960) 128, 12 (1993): 1373-81. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Nelson, K.; Srinivasan, S.; Powell, DE ; Kenady, DE ; DePriest, PD ; Gallion, HH ; Nagell JR, Jr "Resistance to tamoxifen with persisting sensitivity to estrogen: possible mediation by excessive antiestrogen binding site activity." Cancer research 52, 15 (1992): 4106-12. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Nelson, K.; Nagell JR, Jr ; Gallion, HS ; Donaldson, ES ; DePriest, P.; Meares, K.; Nagell JR, 3rd "The growth response of BG-1 ovarian carcinoma cells to estradiol, 4OH-tamoxifen, and tamoxifen: evidence for intrinsic antiestrogen activation." Gynecologic oncology 42, 3 (1991): 245-9. [PubMed Link] |
Nagell JR, Jr ; DePriest, PD ; Puls, LE ; Donaldson, ES ; Gallion, HH ; Pavlik, EJ ; Powell, DE ; Kryscio, RJ "Ovarian cancer screening in asymptomatic postmenopausal women by transvaginal sonography." Cancer 68, 3 (1991): 458-62. [PubMed Link] |
Higgins, RV ; Nagell JR, Jr ; Donaldson, ES ; Gallion, HH ; Pavlik, EJ ; Kryscio, RJ "The efficacy of laser therapy in the treatment of cervical intraepithelial neoplasia." Gynecologic oncology 36, 1 (1990): 79-81. [PubMed Link] |
Nagell JR, Jr ; Higgins, RV ; Donaldson, ES ; Gallion, HH ; Powell, DE ; Pavlik, EJ ; Woods, CH ; Thompson, EA "Transvaginal sonography as a screening method for ovarian cancer. A report of the first 1000 cases screened." Cancer 65, 3 (1990): 573-7. [PubMed Link] |
Pavlik, EJ ; Nelson, K.; Gallion, HH ; Nagell JR, Jr ; Donaldson, ES ; Shih, WJ ; Spicer, JA ; Preston, DF ; Baranczuk, RJ ; Kenady, DE "Characterization of high specific activity 16 alpha-123I Iodo-17 beta-estradiol as an estrogen receptor-specific radioligand capable of imaging estrogen receptor-positive tumors." Cancer research 50, 24 (1990): 7799-805. [PubMed Link] | [ Full text ]
Higgins, RV ; Nagell JR, Jr ; Donaldson, ES ; Gallion, HH ; Pavlik, EJ ; Endicott, B.; Woods, CH "Transvaginal sonography as a screening method for ovarian cancer." Gynecologic oncology 34, 3 (1989): 402-6. [PubMed Link] |
Gallion, HH ; Nagell JR, Jr ; Powell, DF ; Donaldson, ES ; Higgins, RV ; Kryscio, RJ ; Pavlik, EJ ; Nelson, K. "Stage I serous papillary carcinoma of the endometrium." Cancer 63, 11 (1989): 2224-8. [PubMed Link] |
Nelson, K.; Baranowska-Kortylewicz, J.; Nagell JR, Jr ; Gallion, HH ; Donaldson, ES ; Kenady, DE ; McRoberts, WP ; Pavlik, EJ "Intermolecular engagement of estrogen receptors indicated by the formation of a high molecular weight complex during activation." Biochemistry 28, 25 (1989): 9741-9. [PubMed Link] |
Rowley, KC ; Gallion, HH ; Donaldson, ES ; Van Nagell, JR ; Higgins, RV ; Powell, DE ; Kryscio, RJ ; Pavlik, EJ "Prognostic factors in early vulvar cancer." Gynecologic oncology 31, 1 (1988): 43-9. [PubMed Link] |
Nagell JR, Jr ; Powell, DE ; Gallion, HH ; Elliott, DG ; Donaldson, ES ; Carpenter, AE ; Higgins, RV ; Kryscio, R.; Pavlik, EJ "Small cell carcinoma of the uterine cervix." Cancer 62, 8 (1988): 1586-93. [PubMed Link] |
Nelson, K.; Van Nagell, JR ; Gallion, H.; Donaldson, ES ; Pavlik, EJ "Estrogens and antiestrogens mediate contrasting transitions in estrogen receptor conformation which determine chromatin access: a review and synthesis of recent observations." Progress in clinical and biological research 262, (1988): 85-104. [PubMed Link] |
Baranowska-Kortylewicz, J.; Nelson, K.; Pavlik, EJ ; Nagell JR, Jr ; Gallion, HH ; Donaldson, ES ; Kenady, DE "Identification of a very large nuclear estrogen receptor complex." Endocrinology 120, 5 (1987): 2189-91. [PubMed Link] | [ Full text ]
Cibull, ML ; Thompson, ME ; Smith, L.; Jennings, CD ; Doukas, MA ; Pavlik, EJ ; Powell, DE "Marked hypodiploidy in blast phase chronic myelogenous leukemia: report of a case and review of the literature." American journal of hematology 24, 3 (1987): 293-9. [PubMed Link] |
Pavlik, EJ ; Nelson, K.; Nagell JR, Jr ; Donaldson, ES ; Walden, ML ; Gallion, H.; Kenady, DE "Extensive in situ activation of nuclear estrogen receptors after exposure of murine uteri to 3H estradiol or 3H 4-hydroxytamoxifen." Endocrinology 120, 4 (1987): 1608-14. [PubMed Link] | [ Full text ]
Flanigan, RC ; Pavlik, EJ ; Van Nagell, JR ; Keaton, K.; Kenady, DE "Proliferation, esterase activity, and propidium iodide exclusion in urologic tumor cells after in vitro exposure to chemotherapeutic agents." The Journal of urology 135, 5 (1986): 1091-100. [PubMed Link] |
Pavlik, EJ ; Nagell JR, Jr ; Nelson, K.; Gallion, H.; Donaldson, ES ; Kenady, DE ; Baranowska-Kortylewicz, J. "Antagonism to estradiol in the mouse: reduced entry of receptors complexed with 4-hydroxytamoxifen into a Mg2+-soluble chromatin fraction." Endocrinology 118, 5 (1986): 1924-34. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Flanigan, RC ; Bartmas, J.; Nagell JR, Jr ; Donaldson, ES ; Hanson, MB ; Gallion, H.; Kenady, DE "Programming for the DNA analysis of FCM data on an IBM microcomputer." Cytometry 7, 1 (1986): 93-7. [PubMed Link] |
Pavlik, EJ ; Nelson, K.; Gallion, H.; Nagell JR, Jr ; Pursell, S.; Donaldson, ES ; Flanigan, RC ; Kenady, DE "The effects of acute administration of cytotoxic anticancer agents on the capacity for subsequent hormonal responses in the mouse uterus." Journal of steroid biochemistry 25, 2 (1986): 231-7. [PubMed Link] |
Flanigan, RC ; Pavlik, EJ ; Nagell JR, Jr ; Keaton, K.; Ragland, A.; Kenady, DE "Growth of urinary transitional cell carcinoma cell lines in agar, agarose and methyl cellulose." The Journal of urology 134, 5 (1985): 985-90. [PubMed Link] |
Pavlik, EJ ; Nelson, K.; Nagell JR, Jr ; Donaldson, ES ; Walden, ML ; Hanson, MB ; Gallion, H.; Flanigan, RC ; Kenady, DE "Hydrodynamic characterizations of estrogen receptors complexed with 3H -4-hydroxytamoxifen: evidence in support of contrasting receptor transitions mediated by different ligands." Biochemistry 24, 27 (1985): 8101-6. [PubMed Link] |
Hanson, MB ; Nagell JR, Jr ; Powell, DE ; Donaldson, ES ; Gallion, H.; Merhige, M.; Pavlik, EJ "The prognostic significance of lymph-vascular space invasion in stage I endometrial cancer." Cancer 55, 8 (1985): 1753-7. [PubMed Link] |
Pavlik, EJ ; Nelson, K.; Nagell JR, Jr ; Robinson, JC ; Hanson, MB ; Donaldson, ES ; Flanigan, RC ; Kenady, DE "Steroid receptor analysis by size-exclusion liquid chromatography: considerations for the clinical laboratory." Clinical chemistry 31, 4 (1985): 537-45. [PubMed Link] |
Pavlik, EJ ; Flanigan, RC ; Nagell JR, Jr ; Hanson, MB ; Donaldson, ES ; Keaton, K.; Doss, B.; Bartmas, J.; Kenady, DE "Esterase activity, exclusion of propidium iodide, and proliferation in tumor cells exposed to anticancer agents: phenomena relevant to chemosensitivity determinations." Cancer investigation 3, 5 (1985): 413-26. [PubMed Link] | [ Full text ]
Casper, S.; Nagell JR, Jr ; Powell, DF ; Dubilier, LD ; Donaldson, ES ; Hanson, MB ; Pavlik, EJ "Immunohistochemical localization of tumor markers in epithelial ovarian cancer." American journal of obstetrics and gynecology 149, 2 (1984): 154-8. [PubMed Link] | [ Full text ]
Nelson, K.; Pavlik, EJ ; Nagell JR, Jr ; Hanson, MB ; Donaldson, ES ; Flanigan, RC "Estrogenicity of coumestrol in the mouse: fluorescence detection of interaction with estrogen receptors." Biochemistry 23, 12 (1984): 2565-72. [PubMed Link] |
Pavlik, EJ ; Nelson, K.; Nagell JR, Jr ; Christian, J.; Hanson, MB ; Bartmas, J.; Donaldson, ES ; Kenady, DE "VisiCalc and VisiPlot software routines and the analysis of data routinely encountered in steroid biochemistry." Steroids 43, 4 (1984): 393-405. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Kenady, DE ; Nagell JR, Jr ; Hanson, MB ; Donaldson, ES ; Casper, S.; Garrett, D.; Smith, D.; Keaton, K.; Flanigan, RC "Stability of doxorubicin in relation to chemosensitivity determinations: loss of lethality and retention of antiproliferative activity." Cancer investigation 2, 6 (1984): 449-58. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Flanigan, RC ; Nagell JR, Jr ; Swanson, L.; Keaton, K.; Kenady, DE "The effect of different agars, agaroses and methyl cellulose on the in vitro proliferation of a human urinary transitional cell carcinoma cell line." The Journal of urology 129, 6 (1983): 1254-7. [PubMed Link] |
Pavlik, EJ ; Kenady, DE ; Van Nagell, JR ; Keaton, K.; Donaldson, ES ; Hanson, MB ; Flanigan, RC "The proliferation of human tumor cell lines in the presence of different agars, agaroses, and methyl cellulose." In vitro 19, 7 (1983): 538-50. [PubMed Link] |
Pavlik, EJ ; Kenady, DE ; Van Nagell, JR ; Keaton, K.; Hanson, MB ; Donaldson, ES ; Griffen, WO ; Flanigan, RC "Properties of anticancer agents relevant to in vitro determinations of human tumor cell sensitivity." Cancer chemotherapy and pharmacology 11, 1 (1983): 8-15. [PubMed Link] |
Pavlik, EJ ; Nagell JR, Jr ; Hanson, MB ; Donaldson, ES ; Powell, DE ; Kenady, DE "Sensitivity to anticancer agents in vitro: standardizing the cytotoxic response and characterizing the sensitivities of a reference cell line." Gynecologic oncology 14, 2 (1982): 243-61. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Nagell JR, Jr ; Donaldson, E.; Hanson, M. "Some practical aspects of the separation of estrogen and progesterone receptors by size exclusion high performance liquid chromatography which are relevant to quantitation." Journal of steroid biochemistry 17, 5 (1982): 553-8. [PubMed Link] |
Pavlik, EJ ; Nagell JR, Jr ; Muncey, M.; Donaldson, ES ; Hanson, M.; Kenady, D.; Rees, ED ; Talwalkar, VR "Rapid analysis of estrogen and progesterone receptors using gel-exclusion high-performance liquid chromatography." Biochemistry 21, 1 (1982): 139-45. [PubMed Link] |
Pavlik, EJ ; Katzenellenbogen, BS "The intranuclear distribution of rat uterine estrogen receptors determined after nuclease treatment and chromatin fractionation." Molecular and cellular endocrinology 26, 1-2 (1982): 201-16. [PubMed Link] |
Katzenellenbogen, BS ; Pavlik, EJ ; Robertson, DW ; Katzenellenbogen, JA "Interaction of a high affinity anti-estrogen (alpha- 4-pyrrolidinoethoxy phenyl-4-hydroxy-alpha'-nitrostilbene, CI628M) with uterine estrogen receptors." The Journal of biological chemistry 256, 6 (1981): 2908-15. [PubMed Link] | [ Full text ]
Nagell JR, Jr ; Donaldson, ES ; Hanson, MB ; Gay, EC ; Pavlik, EJ "Biochemical markers in the plasma and tumors of patients with gynecologic malignancies." Cancer 48, 2 Suppl (1981): 495-503. [PubMed Link] |
Pavlik, EJ ; Katzenellenbogen, BS "The stability of the uterine estrogen receptor when complexed with estrogens or antiestrogens." Molecular pharmacology 18, 3 (1980): 406-12. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Rutledge, S. "Estrogen-binding properties of cytoplasmic and nuclear estrogen receptors in the presence of Triton X-100." Journal of steroid biochemistry 13, 12 (1980): 1433-41. [PubMed Link] |
Pavlik, EJ ; Rutledge, S.; Eckert, RL ; Katzenellenbogen, BS "Localization of estrogen receptors in uterine cells. An appraisal of translocation." Experimental cell research 123, 1 (1979): 177-89. [PubMed Link] | [ Full text ]
Pavlik, EJ ; Katzenellenbogen, BS "Human endometrial cells in primary tissue culture: estrogen interactions and modulation of cell proliferation." The Journal of clinical endocrinology and metabolism 47, 2 (1978): 333-44. [PubMed Link] | [ Full text ]
Coulson, PB ; Pavlik, EJ "Effects of estrogen and progesterone on cytoplasmic estrogen receptor and rates of protein synthesis in rat uterus." Journal of steroid biochemistry 8, 3 (1977): 205-12. [PubMed Link] |
Pavlik, EJ ; Coulson, PB "Modulation of estrogen receptors in four different target tissues: differential effects of estrogen vs progesterone." Journal of steroid biochemistry 7, 5 (1976): 369-76. [PubMed Link] |
Pavlik, EJ ; Coulson, PB "Hydroxylapatite "batch" assay for estrogen receptors: increased sensitivity over present receptor assays." Journal of steroid biochemistry 7, 5 (1976): 357-68. [PubMed Link] |