Robert S DiPaola, MD

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RSDiPaola@uky.edu
800 Rose St

Position(s):

Dean/Vice Pres Clinical Academic Affairs

Affiliation(s):

Dean's Office

PubMed Publications:

Haas, N.B.;Manola, J.;Dutcher, J.P.;Flaherty, K.T.;Uzzo, R.G.;Atkins, M.B.;DiPaola, R.S.;Choueiri, T.K. "Adjuvant Treatment for High-Risk Clear Cell Renal Cancer: Updated Results of a High-Risk Subset of the ASSURE Randomized Trial." JAMA oncology (2017): [PubMed Link] | [ Full text ]
Ristau, B.T.;Manola, J.;Haas, N.B.;Heng, D.Y.C.;Messing, E.M.;Wood, C.G.;Kane, C.J.;DiPaola, R.S.;Uzzo, R.G. "Retroperitoneal Lymphadenectomy in High-Risk Non-Metastatic Renal Cell Carcinoma: An Analysis of the ASSURE (ECOG-ACRIN 2805) Adjuvant Trial." The Journal of urology (2017): [PubMed Link] | [ Full text ]
Stein, M.N.;Bertino, J.R.;Kaufman, H.L.;Mayer, T.;Moss, R.;Silk, A.;Chan, N.;Malhotra, J.;Rodriguez, L.;Aisner, J.;Aiken, R.D.;Haffty, B.G.;DiPaola, R.S.;Saunders, T.;Zloza, A.;Damare, S.;Beckett, Y.;Yu, B.;Najmi, S.;Gabel, C.;Dickerson, S.;Zheng, L.;El-Deiry, W.S.;Allen, J.E.;Stogniew, M.;Oster, W.;Mehnert, J.M. "First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 23, 15 (2017): 4163-4169. [PubMed Link] | [ Full text ]
Pili, R.;Jegede, O.;Carducci, M.A.;Manola, J.;Groteluschen, D.L.;Appleman, L.L.;Liu, G.;Shanks, J.C.;Dakhil, S.R.;Dutcher, J.;DiPaola, R.S. "A Randomized Phase II Study to Determine the Effect of 2 Different Doses of Aflibercept in Patients With Metastatic Renal Cell Carcinoma (ECOG-ACRIN E4805 )." Clinical genitourinary cancer (2017): [PubMed Link] | [ Full text ]
Foran, D.J.;Chen, W.;Chu, H.;Sadimin, E.;Loh, D.;Riedlinger, G.;Goodell, L.A.;Ganesan, S.;Hirshfield, K.;Rodriguez, L.;DiPaola, R.S. "Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology." Cancer informatics 16, (2017): 1176935117694349. [PubMed Link] |
Ganesan, S.;Rodriguez-Rodriguez, L.;DiPaola, R.S. "Precision Medicine: Implications for Science and Practice." Journal of the American College of Surgeons 223, 3 (2016): 433-439.e1. [PubMed Link] | [ Full text ]
Haas, N.B.;Manola, J.;Uzzo, R.G.;Flaherty, K.T.;Wood, C.G.;Kane, C.;Jewett, M.;Dutcher, J.P.;Atkins, M.B.;Pins, M.;Wilding, G.;Cella, D.;Wagner, L.;Matin, S.;Kuzel, T.M.;Sexton, W.J.;Wong, Y.N.;Choueiri, T.K.;Pili, R.;Puzanov, I.;Kohli, M.;Stadler, W.;Carducci, M.;Coomes, R.;DiPaola, R.S. "Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial." Lancet (London, England) 387, 10032 (2016): 2008-16. [PubMed Link] | [ Full text ]
Mehnert, J.M.;Panda, A.;Zhong, H.;Hirshfield, K.;Damare, S.;Lane, K.;Sokol, L.;Stein, M.N.;Rodriguez-Rodriquez, L.;Kaufman, H.L.;Ali, S.;Ross, J.S.;Pavlick, D.C.;Bhanot, G.;White, E.P.;DiPaola, R.S.;Lovell, A.;Cheng, J.;Ganesan, S. "Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer." The Journal of clinical investigation 126, 6 (2016): 2334-40. [PubMed Link] | [ Full text ]
Heery, C.R.;Madan, R.A.;Stein, M.N.;Stadler, W.M.;DiPaola, R.S.;Rauckhorst, M.;Steinberg, S.M.;Marté, J.L.;Chen, C.C.;Grenga, I.;Donahue, R.N.;Jochems, C.;Dahut, W.L.;Schlom, J.;Gulley, J.L. "Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial." Oncotarget (2016): [PubMed Link] | [ Full text ]
Santanam, U.;Banach-Petrosky, W.;Abate-Shen, C.;Shen, M.M.;White, E.;DiPaola, R.S. "Atg7 cooperates with Pten loss to drive prostate cancer tumor growth." Genes & development 30, 4 (2016): 399-407. [PubMed Link] | [ Full text ]
Stein, M.N.;Hussain, M.;Stadler, W.M.;Liu, G.;Tereshchenko, I.V.;Goodin, S.;Jeyamohan, C.;Kaufman, H.L.;Mehnert, J.;DiPaola, R.S. "A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer." Clinical genitourinary cancer 14, 1 (2016): 22-7. [PubMed Link] | [ Full text ]
Bansal, N.;Bartucci, M.;Yusuff, S.;Davis, S.;Flaherty, K.;Huselid, E.;Patrizii, M.;Jones, D.;Cao, L.;Sydorenko, N.;Moon, Y.C.;Zhong, H.;Medina, D.J.;Kerrigan, J.;Stein, M.N.;Kim, I.Y.;Davis, T.W.;DiPaola, R.S.;Bertino, J.R.;Sabaawy, H.E. "BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 22, 24 (2016): 6176-6191. [PubMed Link] | [ Full text ]
Hirshfield, K.M.;Tolkunov, D.;Zhong, H.;Ali, S.M.;Stein, M.N.;Murphy, S.;Vig, H.;Vazquez, A.;Glod, J.;Moss, R.A.;Belyi, V.;Chan, C.S.;Chen, S.;Goodell, L.;Foran, D.;Yelensky, R.;Palma, N.A.;Sun, J.X.;Miller, V.A.;Stephens, P.J.;Ross, J.S.;Kaufman, H.;Poplin, E.;Mehnert, J.;Tan, A.R.;Bertino, J.R.;Aisner, J.;DiPaola, R.S.;Rodriguez-Rodriguez, L.;Ganesan, S. "Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers." The oncologist (2016): [PubMed Link] | [ Full text ]
Rodriguez-Rodriguez, L.;Hirshfield, K.M.;Rojas, V.;DiPaola, R.S.;Gibbon, D.;Hellmann, M.;Isani, S.;Leiser, A.;Riedlinger, G.M.;Wagreich, A.;Ali, S.M.;Elvin, J.A.;Miller, V.A.;Ganesan, S. "Use of comprehensive genomic profiling to direct point-of-care management of patients with gynecologic cancers." Gynecologic oncology 141, 1 (2016): 2-9. [PubMed Link] | [ Full text ]
Haas, N.B.;Manola, J.;Ky, B.;Flaherty, K.T.;Uzzo, R.G.;Kane, C.J.;Jewett, M.;Wood, L.;Wood, C.G.;Atkins, M.B.;Dutcher, J.J.;Wilding, G.;DiPaola, R.S. "Effects of Adjuvant Sorafenib and Sunitinib on Cardiac Function in Renal Cell Carcinoma Patients without Overt Metastases: Results from ASSURE, ECOG 2805." Clinical cancer research : an official journal of the American Association for Cancer Research 21, 18 (2015): 4048-54. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Chen, Y.H.;Bubley, G.J.;Stein, M.N.;Hahn, N.M.;Carducci, M.A.;Lattime, E.C.;Gulley, J.L.;Arlen, P.M.;Butterfield, L.H.;Wilding, G. "A national multicenter phase 2 study of prostate-specific antigen (PSA) pox virus vaccine with sequential androgen ablation therapy in patients with PSA progression: ECOG 9802." European urology 68, 3 (2015): 365-71. [PubMed Link] | [ Full text ]
Lu-Yao, G.L.;Albertsen, P.C.;Moore, D.F.;Lin, Y.;DiPaola, R.S.;Yao, S.L. "Fifteen-year Outcomes Following Conservative Management Among Men Aged 65 Years or Older with Localized Prostate Cancer." European urology 68, 5 (2015): 805-11. [PubMed Link] | [ Full text ]
Bansal, N.;Mishra, P.J.;Stein, M.;DiPaola, R.S.;Bertino, J.R. "Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells." Oncotarget 6, 17 (2015): 15321-31. [PubMed Link] | [ Full text ]
Flaherty, K.T.;Manola, J.B.;Pins, M.;McDermott, D.F.;Atkins, M.B.;Dutcher, J.J.;George, D.J.;Margolin, K.A.;DiPaola, R.S. "BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma--A Trial of the..." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 33, 21 (2015): 2384-91. [PubMed Link] | [ Full text ]
Lu-Yao, G.L.;Kim, S.;Moore, D.F.;Shih, W.;Lin, Y.;DiPaola, R.S.;Shen, S.;Zietman, A.;Yao, S.L. "Primary radiotherapy vs conservative management for localized prostate cancer--a population-based study." Prostate cancer and prostatic diseases 18, 4 (2015): 317-24. [PubMed Link] | [ Full text ]
Yue, W.;Zheng, X.;Lin, Y.;Yang, C.S.;Xu, Q.;Carpizo, D.;Huang, H.;DiPaola, R.S.;Tan, X.L. "Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2." Oncotarget 6, 25 (2015): 21208-24. [PubMed Link] | [ Full text ]
Yue, W.;Wang, T.;Zachariah, E.;Lin, Y.;Yang, C.S.;Xu, Q.;DiPaola, R.S.;Tan, X.L. "Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy." Scientific reports 5, (2015): 13390. [PubMed Link] | [ Full text ]
Sweeney, C.J.;Chen, Y.H.;Carducci, M.;Liu, G.;Jarrard, D.F.;Eisenberger, M.;Wong, Y.N.;Hahn, N.;Kohli, M.;Cooney, M.M.;Dreicer, R.;Vogelzang, N.J.;Picus, J.;Shevrin, D.;Hussain, M.;Garcia, J.A.;DiPaola, R.S. "Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer." The New England journal of medicine 373, 8 (2015): 737-46. [PubMed Link] | [ Full text ]
McNeel, D.G.;Chen, Y.H.;Gulley, J.L.;Dwyer, A.J.;Madan, R.A.;Carducci, M.A.;DiPaola, R.S. "Randomized phase II trial of docetaxel with or without PSA-TRICOM vaccine in patients with castrate-resistant metastatic prostate cancer: A trial of the ECOG-ACRIN cancer research group (E1809)." Human vaccines & immunotherapeutics 11, 10 (2015): 2469-74. [PubMed Link] | [ Full text ]
Hussain, M.;DiPaola, R.S. "Clinical research in metastatic prostate cancer: a focus on impact and value." American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting (2015): 17-21. [PubMed Link] | [ Full text ]
Lu-Yao, G.L.;Albertsen, P.C.;Moore, D.F.;Shih, W.;Lin, Y.;DiPaola, R.S.;Yao, S.L. "Fifteen-year survival outcomes following primary androgen-deprivation therapy for localized prostate cancer." JAMA internal medicine 174, 9 (2014): 1460-7. [PubMed Link] | [ Full text ]
Huang, H.;He, Y.;Cui, X.X.;Goodin, S.;Wang, H.;Du, Z.Y.;Li, D.;Zhang, K.;Tony Kong, A.N.;DiPaola, R.S.;Yang, C.S.;Conney, A.H.;Zheng, X. "Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo." Journal of agricultural and food chemistry 62, 44 (2014): 10752-8. [PubMed Link] | [ Full text ]
Song, M.;DiPaola, R.S.;Cracchiolo, B.M.;Gibbon, D.G.;Hellmann, M.;Nieves-Neira, W.;Vaidya, A.;Wagreich, A.R.;Shih, W.J.;Rodriguez-Rodriguez, L. "Phase 2 trial of paclitaxel, 13-cis retinoic acid, and interferon alfa-2b in the treatment of advanced stage or recurrent cervical cancer." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 24, 9 (2014): 1636-41. [PubMed Link] | [ Full text ]
Tereshchenko, I.V.;Zhong, H.;Chekmareva, M.A.;Kane-Goldsmith, N.;Santanam, U.;Petrosky, W.;Stein, M.N.;Ganesan, S.;Singer, E.A.;Moore, D.;Tischfield, J.A.;DiPaola, R.S. "ERG and CHD1 heterogeneity in prostate cancer: use of confocal microscopy in assessment of microscopic foci." The Prostate 74, 15 (2014): 1551-9. [PubMed Link] |
Chen, Y.H.;Carducci, M.A.;Liu, G.;Jarrard, D.F.;Eisenberger, M.A.;Wong, Y.N.;Hahn, N.M.;Kohli, M.;Vogelzang, N.J.;Cooney, M.M.;Dreicer, R.;Picus, J.;Shevrin, D.H.;Hussain, M.;Garcia, J.A.;DiPaola, R.S. "Impact on overall survival (OS) with chemohormonal therapy versus hormonal therapy for hormone-sensitive newly metastatic prostate cancer (mPrCa): An ECOG-led phase III randomized trial." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, 18_suppl (2014): LBA2. [PubMed Link] | [ Full text ]
Glod, J.;Song, M.;Sharma, A.;Tyagi, R.;Rhodes, R.H.;Weissmann, D.J.;Roy Chowdhury, S.;Khan, A.;Kane, M.P.;Hirshfield, K.;Ganesan, S.;DiPaola, R.S.;Rodriguez-Rodriguez, L. "Next generation sequencing as an aid to diagnosis and treatment of an unusual pediatric brain cancer." Journal of personalized medicine 4, 3 (2014): 402-11. [PubMed Link] | [ Full text ]
Huang, H.;Cui, X.X.;Chen, S.;Goodin, S.;Liu, Y.;He, Y.;Li, D.;Wang, H.;Van Doren, J.;DiPaola, R.S.;Conney, A.H.;Zheng, X. "Combination of Lipitor and Celebrex inhibits prostate cancer VCaP cells in vitro and in vivo." Anticancer research 34, 7 (2014): 3357-63. [PubMed Link] | [ Full text ]
Pillai, R.N.;Aisner, J.;Dahlberg, S.E.;Rogers, J.S.;DiPaola, R.S.;Aisner, S.;Ramalingam, S.S.;Schiller, J.H. "Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501)." Cancer chemotherapy and pharmacology 74, 1 (2014): 177-83. [PubMed Link] | [ Full text ]
Wang, H.;Cui, X.X.;Goodin, S.;Ding, N.;Van Doren, J.;Du, Z.;Huang, M.T.;Liu, Y.;Cheng, X.;DiPaola, R.S.;Conney, A.H.;Zheng, X. "Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib." Oncology reports 31, 2 (2014): 835-41. [PubMed Link] | [ Full text ]
Bansal, N.;Davis, S.;Tereshchenko, I.;Budak-Alpdogan, T.;Zhong, H.;Stein, M.N.;Kim, I.Y.;DiPaola, R.S.;Bertino, J.R.;Sabaawy, H.E. "Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion." The Prostate 74, 2 (2014): 187-200. [PubMed Link] |
Richie JP, J.;Das, A.;Calcagnotto, A.M.;Sinha, R.;Neidig, W.;Liao, J.;Lengerich, E.J.;Berg, A.;Hartman, T.J.;Ciccarella, A.;Baker, A.;Kaag, M.G.;Goodin, S.;DiPaola, R.S.;El-Bayoumy, K. "Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial." Cancer prevention research (Philadelphia, Pa.) 7, 8 (2014): 796-804. [PubMed Link] | [ Full text ]
Yue, W.;Yang, C.S.;DiPaola, R.S.;Tan, X.L. "Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment." Cancer prevention research (Philadelphia, Pa.) 7, 4 (2014): 388-97. [PubMed Link] | [ Full text ]
Padmanabhan, R.K.;Somasundar, V.H.;Griffith, S.D.;Zhu, J.;Samoyedny, D.;Tan, K.S.;Hu, J.;Liao, X.;Carin, L.;Yoon, S.S.;Flaherty, K.T.;DiPaola, R.S.;Heitjan, D.F.;Lal, P.;Feldman, M.D.;Roysam, B.;Lee, W.M. "An active learning approach for rapid characterization of endothelial cells in human tumors." PloS one 9, 3 (2014): e90495. [PubMed Link] | [ Full text ]
Singer, E.A.;DiPaola, R.S. "Our shifting understanding of factors influencing prostate-specific antigen." Journal of the National Cancer Institute 105, 17 (2013): 1264-5. [PubMed Link] | [ Full text ]
Tedeschi, P.M.;Markert, E.K.;Gounder, M.;Lin, H.;Dvorzhinski, D.;Dolfi, S.C.;Chan, L.L.;Qiu, J.;DiPaola, R.S.;Hirshfield, K.M.;Boros, L.G.;Bertino, J.R.;Oltvai, Z.N.;Vazquez, A. "Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells." Cell death & disease 4, (2013): e877. [PubMed Link] | [ Full text ]
Kang, W.;DiPaola, R.S.;Vazquez, A. "Inference of synergy/antagonism between anticancer drugs from the pooled analysis of clinical trials." BMC medical research methodology 13, (2013): 77. [PubMed Link] | [ Full text ]
Guo, J.Y.;Karsli-Uzunbas, G.;Mathew, R.;Aisner, S.C.;Kamphorst, J.J.;Strohecker, A.M.;Chen, G.;Price, S.;Lu, W.;Teng, X.;Snyder, E.;Santanam, U.;DiPaola, R.S.;Jacks, T.;Rabinowitz, J.D.;White, E. "Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis." Genes & development 27, 13 (2013): 1447-61. [PubMed Link] | [ Full text ]
Sha, Y.;Goodin, S.;DiPaola, R.S.;Kim, I.Y. "Enzalutamide for the treatment of castration-resistant prostate cancer." Drugs of today (Barcelona, Spain : 1998) 49, 1 (2013): 7-13. [PubMed Link] | [ Full text ]
Moore, D.;Lin, Y.;Demissie, K.;Shih, W.;Albertsen, P.C.;DiPaola, R.S.;Yao, S.L. "Racial differences in survival outcomes among men with localized prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, 6_suppl (2013): 98. [PubMed Link] | [ Full text ]
Madan, R.A.;Stein, W.D.;Wilkerson, J.;Dahut, W.L.;Heery, C.R.;Schlom, J.;Wilding, G.;DiPaola, R.S. "Effect of PSA-tricom, a pox-viral vaccine in prostate cancer (PCa), on tumor growth rates within 80 days after initiation in nonmetastatic PCa." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, 6_suppl (2013): 57. [PubMed Link] | [ Full text ]
Madan, R.A.;Bilusic, M.;Kim, J.W.;Singh, N.K.;Rauckhorst, M.;Steinberg, S.M.;Dahut, W.L.;Chen, C.;DiPaola, R.S.;Stein, M.N.;Panicali, D.;Hodge, J.W.;Schlom, J.;Gulley, J.L. "A phase II randomized clinical trial of samarium-153 EDTMP (Sm-153) with or without PSA-TRICOM vaccine in metastatic castration-resistant prostate cancer (mCRPC) after docetaxel." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, 6_suppl (2013): 102. [PubMed Link] | [ Full text ]
Huzzy, L.;Anand, M.;Jeyamohan, C.;Mayer, T.M.;DiPaola, R.S.;Gharibo, M.M.;Strair, R. "Sunitinib (SU) plus extended courses of irradiated allogeneic lymphocytes (IAL) for patients with metastatic renal cell carcinoma (RCC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, 6_suppl (2013): 464. [PubMed Link] | [ Full text ]
Manola, J.;Pins, M.;Flaherty, K.T.;Atkins, M.B.;Dutcher, J.P.;George, D.J.;Margolin, K.A.;DiPaola, R.S. "The BEST trial (E2804): A randomized phase II study of VEGF, RAF kinase, and mTOR combination targeted therapy (CTT) with bevacizumab (bev), sorafenib (sor), and temsirolimus (tem) in advanced renal cell carcinoma (RCC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, 6_suppl (2013): 345. [PubMed Link] | [ Full text ]
Goodin, S.;DiPaola, R.S. "Cabozantinib in prostate cancer: the beginning of a precision paradigm?" Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, 4 (2013): 401-3. [PubMed Link] | [ Full text ]
Raez, L.E.;Papadopoulos, K.;Ricart, A.D.;Chiorean, E.G.;DiPaola, R.S.;Stein, M.N.;Rocha Lima, C.M.;Schlesselman, J.J.;Tolba, K.;Langmuir, V.K.;Kroll, S.;Jung, D.T.;Kurtoglu, M.;Rosenblatt, J.;Lampidis, T.J. "A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors." Cancer chemotherapy and pharmacology 71, 2 (2013): 523-30. [PubMed Link] | [ Full text ]
Hudson, S.V.;Miller, S.M.;Hemler, J.;Ferrante, J.M.;Lyle, J.;Oeffinger, K.C.;DiPaola, R.S. "Adult cancer survivors discuss follow-up in primary care: 'not what i want, but maybe what i need'." Annals of family medicine 10, 5 (2012): 418-27. [PubMed Link] | [ Full text ]
Saleem, A.;Dvorzhinski, D.;Santanam, U.;Mathew, R.;Bray, K.;Stein, M.;White, E.;DiPaola, R.S. "Effect of dual inhibition of apoptosis and autophagy in prostate cancer." The Prostate 72, 12 (2012): 1374-81. [PubMed Link] |
Gounder, M.K.;Lin, H.;Stein, M.;Goodin, S.;Bertino, J.R.;Kong, A.N.;DiPaola, R.S. "A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma." Biomedical chromatography : BMC 26, 5 (2012): 650-4. [PubMed Link] | [ Full text ]
Lin, H.;Gounder, M.K.;Bertino, J.R.;Kong, A.N.;DiPaola, R.S.;Stein, M.N. "A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies." Journal of pharmaceutical and biomedical analysis 66, (2012): 371-5. [PubMed Link] | [ Full text ]
Goodin, S.;Stein, M.N.;Shih, W.;Lu, S.E.;Zheng, X.;Anand, M.;Jeyamohan, C.;Mayer, T.M.;Somer, R.A.;Heath, E.;Conney, A.;DiPaola, R.S. "A phase II study of atorvastatin and celecoxib in patients with rising PSA following local therapy for prostate cancer (PC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 30, 5_suppl (2012): 89. [PubMed Link] |
Stein, M.N.;DiPaola, R.S.;Mayer, T.M.;Jeyamohan, C.;Metzger, D.;Anand, M.;Ivy, S.P.;Prostate Cancer Clinical Trials, C. "A randomized phase II study of bicalutamide (BIC) followed by placebo or gamma secretase inhibitor RO4929097 (RO492) in men with rising PSA." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 30, 5_suppl (2012): 219. [PubMed Link] |
Goodin, S.;Stein, M.N.;Shih, W.;Lu, S.E.;Zheng, X.;Anand, M.;Jeyamohan, C.;Mayer, T.M.;Somer, R.A.;Heath, E.;Conney, A.;DiPaola, R.S. "A phase II study of atorvastatin and celecoxib in patients with rising PSA following local therapy for prostate cancer (PC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 30, 5_suppl (2012): 89. [PubMed Link] | [ Full text ]
Stein, M.N.;DiPaola, R.S.;Mayer, T.M.;Jeyamohan, C.;Metzger, D.;Anand, M.;Ivy, S.P.;Prostate Cancer Clinical Trials, C. "A randomized phase II study of bicalutamide (BIC) followed by placebo or gamma secretase inhibitor RO4929097 (RO492) in men with rising PSA." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 30, 5_suppl (2012): 219. [PubMed Link] | [ Full text ]
Lu-Yao, G.L.;Albertsen, P.C.;Li, H.;Moore, D.F.;Shih, W.;Lin, Y.;DiPaola, R.S.;Yao, S.L. "Does primary androgen-deprivation therapy delay the receipt of secondary cancer therapy for localized prostate cancer?" European urology 62, 6 (2012): 966-72. [PubMed Link] | [ Full text ]
Stein, M.N.;Goodin, S.;DiPaola, R.S. "Abiraterone in prostate cancer: a new angle to an old problem." Clinical cancer research : an official journal of the American Association for Cancer Research 18, 7 (2012): 1848-54. [PubMed Link] | [ Full text ]
Stein, M.;Goodin, S.;Doyle-Lindrud, S.;Silberberg, J.;Kane, M.;Metzger, D.;Eddy, S.;Shih, W.;DiPaola, R.S. "Transdermal estradiol in castrate and chemotherapy resistant prostate cancer." Medical science monitor : international medical journal of experimental and clinical research 18, 4 (2012): CR260-4. [PubMed Link] | [ Full text ]
Bray, K.;Mathew, R.;Lau, A.;Kamphorst, J.J.;Fan, J.;Chen, J.;Chen, H.Y.;Ghavami, A.;Stein, M.;DiPaola, R.S.;Zhang, D.;Rabinowitz, J.D.;White, E. "Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition." PloS one 7, 7 (2012): e41831. [PubMed Link] | [ Full text ]
Zheng, X.;Cui, X.X.;Khor, T.O.;Huang, Y.;DiPaola, R.S.;Goodin, S.;Lee, M.J.;Yang, C.S.;Kong, A.N.;Conney, A.H. "Inhibitory Effect of a γ-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice." Cancers 3, 4 (2011): 3762-72. [PubMed Link] | [ Full text ]
Liu, G.;Chen, Y.;DiPaola, R.S.;Carducci, M.A.;Wilding, G.;Eastern Cooperative Oncology, G. "Final results on phase II study of a weekly schedule of ixabepilone in patients with metastatic castrate-refractory prostate cancer (E3803): A trial of the Eastern Cooperative Oncology Group." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 15_suppl (2011): 4529. [PubMed Link] |
Bhatt, R.S.;Manola, J.;Bullock, A.J.;Zhang, L.;Haas, N.B.;Pins, M.;Atkins, M.B.;DiPaola, R.S. "Host-mediated changes in patients receiving antiangiogenic therapy for resected RCC." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 15_suppl (2011): 4557. [PubMed Link] |
Tan, A.R.;Toppmeyer, D.;Stein, M.N.;Moss, R.A.;Gounder, M.;Lindquist, D.C.;Ji, J.J.;Chen, A.P.;Egorin, M.J.;Kiesel, B.;Beumer, J.H.;DiPaola, R.S. "Phase I trial of veliparib, (ABT-888), a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with doxorubicin and cyclophosphamide in breast cancer and other solid tumors." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 15_suppl (2011): 3041. [PubMed Link] |
Stein, M.N.;Tan, A.R.;Mehnert, J.M.;Gibbon, D.;DiPaola, R.S.;Moss, R.A.;Poplin, E.;Rubin, E.H.;Saraiya, B.;Kane, M.P.;Scott, P.;LaRosiliere, M.;Camisa, H.;Kirin, P.;Thomas, C.M.;Aisner, J. "Is there a therapeutic benefit for patients participating in modern phase I trials?" Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 15_suppl (2011): 2523. [PubMed Link] |
Guo, J.Y.;Chen, H.Y.;Mathew, R.;Fan, J.;Strohecker, A.M.;Karsli-Uzunbas, G.;Kamphorst, J.J.;Chen, G.;Lemons, J.M.;Karantza, V.;Coller, H.A.;DiPaola, R.S.;Gelinas, C.;Rabinowitz, J.D.;White, E. "Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis." Genes & development 25, 5 (2011): 460-70. [PubMed Link] | [ Full text ]
Ferrari, A.C.;Stein, M.N.;Alumkal, J.J.;Gomez-Pinillos, A.;Catamero, D.D.;Mayer, T.M.;Collins, F.;Beer, T.M.;DiPaola, R.S.;Prostate Cancer Clinical Trials, C. "A phase I/II randomized study of panobinostat and bicalutamide in castration-resistant prostate cancer (CRPC) patients progressing on second-line hormone therapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 7_suppl (2011): 156. [PubMed Link] |
Stein, M.N.;Khan, I.;Hussain, M.;Liu, G.;Wilding, G.;Posadas, E.M.;Stadler, W.M.;Jeyamohan, C.;Eddy, S.;DiPaola, R.S.;Prostate Cancer Clinical Trials, C. "Phase II study of AT-101 to abrogate Bcl-2-mediated resistance to androgen-deprivation therapy (ADT) in patients (pts) with newly diagnosed androgen-dependent metastatic prostate cancer (ADMPC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 7_suppl (2011): 137. [PubMed Link] |
McCarthy, T.;Mayer, T.M.;Stein, M.N.;Anand, M.;Collins, F.;Jeyamohan, C.;Metzger, D.;Moore, D.;White, E.;DiPaola, R.S. "Modulating autophagy using hydroxychloroquine (HCQ) in patients with hormone-dependent PSA progression after local therapy for prostate cancer (PC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 7_suppl (2011): 164. [PubMed Link] |
Lu-Yao, G.L.;Kim, S.;Moore, D.;Shih, W.;Lin, Y.;DiPaola, R.S.;Zietman, A.L.;Yao, S. "Is radiation therapy superior to conservative management in men with localized prostate cancer?" Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 7_suppl (2011): 73. [PubMed Link] |
Amaravadi, R.K.;Lippincott-Schwartz, J.;Yin, X.M.;Weiss, W.A.;Takebe, N.;Timmer, W.;DiPaola, R.S.;Lotze, M.T.;White, E. "Principles and current strategies for targeting autophagy for cancer treatment." Clinical cancer research : an official journal of the American Association for Cancer Research 17, 4 (2011): 654-66. [PubMed Link] | [ Full text ]
Bradley, D.A.;Daignault, S.;Ryan, C.J.;DiPaola, R.S.;Cooney, K.A.;Smith, D.C.;Small, E.;Mathew, P.;Gross, M.E.;Stein, M.N.;Chen, A.;Pienta, K.J.;Escara-Wilke, J.;Doyle, G.;Al-Hawary, M.;Keller, E.T.;Hussain, M. "Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium." Investigational new drugs 29, 6 (2011): 1432-40. [PubMed Link] | [ Full text ]
Delnevo, C.D.;Steinberg, M.B.;Hudson, S.V.;Ulpe, R.;DiPaola, R.S. "Epidemiology of Cigarette and Smokeless Tobacco Use among South Asian Immigrants in the Northeastern United States." Journal of oncology 2011, (2011): 252675. [PubMed Link] | [ Full text ]
Stein, M.;Lin, H.;Jeyamohan, C.;Dvorzhinski, D.;Gounder, M.;Bray, K.;Eddy, S.;Goodin, S.;White, E.;DiPaola, R.S. "Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies." The Prostate 70, 13 (2010): 1388-94. [PubMed Link] |
Parekh, N.;Lin, Y.;DiPaola, R.S.;Marcella, S.;Lu-Yao, G. "Obesity and prostate cancer detection: insights from three national surveys." The American journal of medicine 123, 9 (2010): 829-35. [PubMed Link] | [ Full text ]
Shao, Y.H.;Albertsen, P.C.;Roberts, C.B.;Lin, Y.;Mehta, A.R.;Stein, M.N.;DiPaola, R.S.;Lu-Yao, G.L. "Risk profiles and treatment patterns among men diagnosed as having prostate cancer and a prostate-specific antigen level below 4.0 ng/ml." Archives of internal medicine 170, 14 (2010): 1256-61. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Chen, Y.H.;Stein, M.;Vaughn, D.;Patrick-Miller, L.;Carducci, M.;Roth, B.;White, E.;Wilding, G. "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899." Journal of translational medicine 8, (2010): 20. [PubMed Link] | [ Full text ]
Lu-Yao, G.L.;Albertsen, P.C.;Moore, D.F.;Shih, W.;Lin, Y.;DiPaola, R.S.;Barry, M.J.;Zietman, A.;O'Leary, M.;Walker-Corkery, E.;Yao, S.L. "Outcomes of localized prostate cancer following conservative management." JAMA 302, 11 (2009): 1202-9. [PubMed Link] | [ Full text ]
Shao, Y.H.;Demissie, K.;Shih, W.;Mehta, A.R.;Stein, M.N.;Roberts, C.B.;DiPaola, R.S.;Lu-Yao, G.L. "Contemporary risk profile of prostate cancer in the United States." Journal of the National Cancer Institute 101, 18 (2009): 1280-3. [PubMed Link] | [ Full text ]
White, E.;DiPaola, R.S. "The double-edged sword of autophagy modulation in cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 15, 17 (2009): 5308-16. [PubMed Link] | [ Full text ]
Bray, K.;Chen, H.Y.;Karp, C.M.;May, M.;Ganesan, S.;Karantza-Wadsworth, V.;DiPaola, R.S.;White, E. "Bcl-2 modulation to activate apoptosis in prostate cancer." Molecular cancer research : MCR 7, 9 (2009): 1487-96. [PubMed Link] | [ Full text ]
Hussain, M.;Goldman, B.;Tangen, C.;Higano, C.S.;Petrylak, D.P.;Wilding, G.;Akdas, A.M.;Small, E.J.;Donnelly, B.J.;Sundram, S.K.;Burch, P.A.;DiPaola, R.S.;Crawford, E.D. "Prostate-specific antigen progression predicts overall survival in patients with metastatic prostate cancer: data from Southwest Oncology Group Trials 9346 (Intergroup Study 0162) and 9916." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27, 15 (2009): 2450-6. [PubMed Link] | [ Full text ]
Lu-Yao, G.;Albertsen, P.C.;Moore, D.F.;Lin, Y.;Shih, W.;Barry, M.J.;Zietman, A.;O'Leary, M.;Walker-Corkery, E.;DiPaola, R.S.;Yao, S. "Outcomes of conservatively managed localized prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27, 15_suppl (2009): 5010. [PubMed Link] |
Karantza-Wadsworth, V.;Stein, M.;Tan, A.;Mehnert, J.;Poplin, E.;Lin, Y.;White, E.;DiPaola, R.S. "Rationally designed treatment for solid tumors with MAPK pathway activation." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27, 15_suppl (2009): 2532. [PubMed Link] |
Jiang, Y.;DiPaola, R.S.;Hu, L. "Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA)." Bioorganic & medicinal chemistry letters 19, 9 (2009): 2587-90. [PubMed Link] | [ Full text ]
Hussain, A.;DiPaola, R.S.;Baron, A.D.;Higano, C.S.;Tchekmedyian, N.S.;Johri, A.R. "Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer." Annals of oncology : official journal of the European Society for Medical Oncology 20, 3 (2009): 492-7. [PubMed Link] | [ Full text ]
Mathew, R.;Karp, C.M.;Beaudoin, B.;Vuong, N.;Chen, G.;Chen, H.Y.;Bray, K.;Reddy, A.;Bhanot, G.;Gelinas, C.;DiPaola, R.S.;Karantza-Wadsworth, V.;White, E. "Autophagy suppresses tumorigenesis through elimination of p62." Cell 137, 6 (2009): 1062-75. [PubMed Link] | [ Full text ]
Yao, S.;Moore, D.F.;Shih, W.J.;Lin, Y.;DiPaola, R.S.;Albertsen, P.C.;Lu-Yao, G.L. "Survival following primary androgen deprivation therapy among men with localized prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26, 15_suppl (2008): 5014. [PubMed Link] |
DiPaola, R.S.;Stein, M.N.;Goodin, S.;Eddy, S.;Rubin, E.H.;Doyle-Lindrud, S.;Dvorzhinski, D.;Beers, S.;Shih, W.J.;White, E. "Warburg science goes to the bedside: A phase I trial of 2-deoxyglucose in patients with prostate cancer and advanced malignancies." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26, 15_suppl (2008): 16087. [PubMed Link] |
Mehta, A.;Anand, R.;Stein, M.N.;Shih, W.J.;Goodin, S.;DiPaola, R.S. "Long-term outcome of patients treated with docetaxel for hormone-dependent prostate-specific antigen (PSA) progression after local therapy for prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26, 15_suppl (2008): 16030. [PubMed Link] |
Lu-Yao, G.L.;Albertsen, P.C.;Moore, D.F.;Shih, W.;Lin, Y.;DiPaola, R.S.;Yao, S.L. "Survival following primary androgen deprivation therapy among men with localized prostate cancer." JAMA 300, 2 (2008): 173-81. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Gallo, M.A. "Hearsay medicine is not evidence-based medicine." Clinical cancer research : an official journal of the American Association for Cancer Research 14, 2 (2008): 337-8. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Dvorzhinski, D.;Thalasila, A.;Garikapaty, V.;Doram, D.;May, M.;Bray, K.;Mathew, R.;Beaudoin, B.;Karp, C.;Stein, M.;Foran, D.J.;White, E. "Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy." The Prostate 68, 16 (2008): 1743-52. [PubMed Link] |
Bradley, D.A.;Hussain, M.;DiPaola, R.S.;Kantoff, P. "Bone directed therapies for prostate cancer." The Journal of urology 178, 3 Pt 2 (2007): S42-8. [PubMed Link] | [ Full text ]
Kantoff, P.W.;Beer, T.M.;D'Amico, A.V.;DiPaola, R.S.;Eisenberger, M.A.;Hussain, M.H.;Kelly, W.K.;Mathew, P.;Morris, M.J.;Ryan, C.J.;Sandler, H.M.;Thompson, I.M.;Carroll, P.R. "Innovations and challenges in prostate cancer: summary statement for the 6th Cambridge Conference." The Journal of urology 178, 3 Pt 2 (2007): S5-8; quiz S4. [PubMed Link] | [ Full text ]
Small, E.J.;Fontana, J.;Tannir, N.;DiPaola, R.S.;Wilding, G.;Rubin, M.;Iacona, R.B.;Kabbinavar, F.F. "A phase II trial of gefitinib in patients with non-metastatic hormone-refractory prostate cancer." BJU international 100, 4 (2007): 765-9. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Lattime, E.C. "Bacillus Calmette-Guerin mechanism of action: the role of immunity, apoptosis, necrosis and autophagy." The Journal of urology 178, 5 (2007): 1840-1. [PubMed Link] | [ Full text ]
Kibel, A.S.;Rosenbaum, E.;Kattan, M.W.;Picus, J.;Dreicer, R.;Klein, E.A.;Chatta, G.S.;Nelson, J.B.;DiPaola, R.S.;Roth, B.J.;Cookson, M.S.;Wilding, G.;Jarrard, D.F.;Beer, T.M.;Ryan, C.W.;Petrylak, D.P.;Benson, M.C.;Partin, A.W.;Garrett-Mayer, E.;Eisenberger, M.A. "Adjuvant weekly docetaxel for patients with high risk prostate cancer after radical prostatectomy: a multi-institutional pilot study." The Journal of urology 177, 5 (2007): 1777-81. [PubMed Link] | [ Full text ]
Jin, S.;DiPaola, R.S.;Mathew, R.;White, E. "Metabolic catastrophe as a means to cancer cell death." Journal of cell science 120, Pt 3 (2007): 379-83. [PubMed Link] | [ Full text ]
Lu-Yao, G.;Moore, D.F.;Oleynick, J.U.;DiPaola, R.S.;Yao, S.L. "Population based study of hormonal therapy and survival in men with metastatic prostate cancer." The Journal of urology 177, 2 (2007): 535-9. [PubMed Link] | [ Full text ]
Goodin, S.;Shen, F.;Shih, W.J.;Dave, N.;Kane, M.P.;Medina, P.;Lambert, G.H.;Aisner, J.;Gallo, M.;DiPaola, R.S. "Clinical and biological activity of soy protein powder supplementation in healthy male volunteers." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 16, 4 (2007): 829-33. [PubMed Link] | [ Full text ]
Banach-Petrosky, W.;Ouyang, X.;Gao, H.;Nader, K.;Ji, Y.;Suh, N.;DiPaola, R.S.;Abate-Shen, C. "Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1;Pten mutant mice." Clinical cancer research : an official journal of the American Association for Cancer Research 12, 19 (2006): 5895-901. [PubMed Link] | [ Full text ]
Vaughn, D.J.;Powell, M.;Catalano, P.J.;Loehrer, P.;Nichols, C.;Sweeney, C.;Wilding, G.;DiPaola, R.S. "The influence of body mass index (BMI) on outcome in patients with advanced germ cell tumors (GCT)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24, 18_suppl (2006): 14594. [PubMed Link] |
Mehta, A.;Stein, M.;Goodin, S.;Yao, S.;Shih, J.;Todd, M.;DiPaola, R.S. "Pre-treatment PSA doubling time (PSADT) predicts biochemical response to chemotherapy in patients with androgen sensitive PSA progression after local therapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24, 18_suppl (2006): 14528. [PubMed Link] |
DiPaola, R.S.;Plante, M.;Kaufman, H.;Petrylak, D.P.;Israeli, R.;Lattime, E.;Manson, K.;Schuetz, T. "A phase I trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer." Journal of translational medicine 4, (2006): 1. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Morton, R.A. "Proven and unproven therapy for benign prostatic hyperplasia." The New England journal of medicine 354, 6 (2006): 632-4. [PubMed Link] | [ Full text ]
Lu-Yao, G.;Moore, D.F.;Oleynick, J.;DiPaola, R.S.;Yao, S.L. "Use of hormonal therapy in men with metastatic prostate cancer." The Journal of urology 176, 2 (2006): 526-31. [PubMed Link] | [ Full text ]
Gray, R.;Manola, J.;Saxman, S.;Wright, J.;Dutcher, J.;Atkins, M.;Carducci, M.;See, W.;Sweeney, C.;Liu, G.;Stein, M.;Dreicer, R.;Wilding, G.;DiPaola, R.S. "Phase II clinical trial design: methods in translational research from the Genitourinary Committee at the Eastern Cooperative Oncology Group." Clinical cancer research : an official journal of the American Association for Cancer Research 12, 7 Pt 1 (2006): 1966-9. [PubMed Link] | [ Full text ]
Goodin, S.;Medina, P.;Capanna, T.;Shih, W.J.;Abraham, S.;Winnie, J.;Doyle-Lindrud, S.;Todd, M.;DiPaola, R.S. "Effect of docetaxel in patients with hormone-dependent prostate-specific antigen progression after local therapy for prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, 15 (2005): 3352-7. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Thompson, I.M. "National cooperative group trials." Urology 65, 5 Suppl (2005): 23-9; discussion 29. [PubMed Link] | [ Full text ]
Morris, M.J.;Cordon-Cardo, C.;Kelly, W.K.;Slovin, S.F.;Siedlecki, K.;Regan, K.P.;DiPaola, R.S.;Rafi, M.;Rosen, N.;Scher, H.I. "Safety and biologic activity of intravenous BCL-2 antisense oligonucleotide (G3139) and taxane chemotherapy in patients with advanced cancer." Applied immunohistochemistry & molecular morphology : AIMM 13, 1 (2005): 6-13. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Dvorzhinski, D.;Nelson, D.;Garikapaty, V.;White, E. "2-deoxyglucose (2DG) bypasses Bcl-2 and Akt mediated resistance in prostate cells." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, 16_suppl (2005): 9535. [PubMed Link] |
Kaufman, H.L.;Wang, W.;Manola, J.;DiPaola, R.S.;Ko, Y.J.;Sweeney, C.J.;Whiteside, T.;Schlom, J.;Wilding, G.;Weiner, L.M. "Phase II prime/boost vaccination using poxviruses expressing PSA in hormone dependent prostate cancer: Follow-up clinical results from ECOG 7897." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, 16_suppl (2005): 4501. [PubMed Link] |
Lu-Yao, G.L.;Moore, D.F.;DiPaola, R.S.;Yao, S.L. "Use of hormonal therapy in men with metastatic prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, 16_suppl (2005): 4559. [PubMed Link] |
Lattime, E.C.;Weiss, R.E.;Stein, M.N.;Wojtowicz, M.;Todd, M.B.;Morton, R.A.;Wang, J.H.;Bancila, E.;Ben-Menachem, T.;DiPaola, R.S. "Phase I study of intravesical recombinant fowlpox-GM-CSF (rF-GMCSF) and/or recombinant Fowlpox-TRICOM (rF-TRICOM) in patients with advanced bladder cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, 16_suppl (2005): 4755. [PubMed Link] |
Stein, M.N.;Todd, M.B.;Morton, R.A.;Doyle-Lindrud, S.;Goodin, S.;Shah, A.;Shih, W.;Garikapaty, V.;Dvorzhinski, D.;DiPaola, R.S. "A completed phase I trial of 13-cis retinoic acid, alpha interferon, docetaxel, and estramustine (R.I.T.E.) for the treatment of hormone refractory prostate cancer (HRPC) and other advanced malignancies and effect on BCL-2 expression." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, 16_suppl (2005): 4740. [PubMed Link] |
Rafi, M.M.;Bai, N.S.;, C.T.H.;Rosen, R.T.;White, E.;Perez, D.;DiPaola, R.S. "A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation." Anticancer research 25, 1A (2005): 313-8. [PubMed Link] | [ Full text ]
Rao, K.;Goodin, S.;Levitt, M.J.;Dave, N.;Shih, W.J.;Lin, Y.;Capanna, T.;Doyle-Lindrud, S.;Juvidian, P.;DiPaola, R.S. "A phase II trial of imatinib mesylate in patients with prostate specific antigen progression after local therapy for prostate cancer." The Prostate 62, 2 (2005): 115-22. [PubMed Link] |
Arlen, P.M.;Kaufman, H.L.;DiPaola, R.S. "Pox viral vaccine approaches." Seminars in oncology 32, 6 (2005): 549-55. [PubMed Link] | [ Full text ]
Goodin, S.;Rao, K.V.;Kane, M.;Dave, N.;Capanna, T.;Doyle-Lindrud, S.;Engle, E.;Jin, L.;Todd, M.;DiPaola, R.S. "A phase II trial of docetaxel and vinorelbine in patients with hormone-refractory prostate cancer." Cancer chemotherapy and pharmacology 56, 2 (2005): 199-204. [PubMed Link] | [ Full text ]
Oh, W.K.;Kantoff, P.W.;Weinberg, V.;Jones, G.;Rini, B.I.;Derynck, M.K.;Bok, R.;Smith, M.R.;Bubley, G.J.;Rosen, R.T.;DiPaola, R.S.;Small, E.J. "Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 18 (2004): 3705-12. [PubMed Link] | [ Full text ]
Dvorzhinski, D.;Thalasila, A.;Thomas, P.E.;Nelson, D.;Li, H.;White, E.;DiPaola, R.S. "A novel proteomic coculture model of prostate cancer cell growth." Proteomics 4, 10 (2004): 3268-75. [PubMed Link] | [ Full text ]
Ioffe, M.L.;White, E.;Nelson, D.A.;Dvorzhinski, D.;DiPaola, R.S. "Epothilone induced cytotoxicity is dependent on p53 status in prostate cells." The Prostate 61, 3 (2004): 243-7. [PubMed Link] |
Kumar, P.;Perrotti, M.;Weiss, R.;Todd, M.;Goodin, S.;Cummings, K.;DiPaola, R.S. "Phase I trial of weekly docetaxel with concurrent three-dimensional conformal radiation therapy in the treatment of unfavorable localized adenocarcinoma of the prostate." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 10 (2004): 1909-15. [PubMed Link] | [ Full text ]
Kaufman, H.L.;Wang, W.;Manola, J.;DiPaola, R.S.;Ko, Y.J.;Sweeney, C.;Whiteside, T.L.;Schlom, J.;Wilding, G.;Weiner, L.M. "Phase II randomized study of vaccine treatment of advanced prostate cancer (E7897): a trial of the Eastern Cooperative Oncology Group." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 11 (2004): 2122-32. [PubMed Link] | [ Full text ]
Elsayed, Y.A.;Altscher, A.;Hillard, B.;Doyle-Lindrud, S.;Teller, E.;Goodin, S.;Shih, W.J.;Rubin, E.H.;DiPaola, R.S. "A phase I/II trial of 13-cis retinoic acid, alpha interferon, docetaxel, and estramustine (R.I.T.E.) for the treatment of hormone refractory prostate cancer (HRPC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14_suppl (2004): 4707. [PubMed Link] |
DiPaola, R.S.;Manola, J.;Li, S.;Vaughn, D.;Roth, B.;Wilding, G. "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic hormone refractory prostate cancer: results of ECOG 3899." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14_suppl (2004): 4594. [PubMed Link] |
Hussain, A.;DiPaola, R.S.;Baron, A.D.;Higano, C.S.;Tchekmediyan, N.S.;Miller, J.A.;Rothermel, J.D. "A Phase IIa trial of weekly EPO906 in patients with hormone-refractory prostate cancer (HPRC)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14_suppl (2004): 4563. [PubMed Link] |
Rosenbaum, E.;Kibel, A.;Roth, B.J.;Wilding, G.;Dreicer, R.;Chatta, G.;Petrylak, D.;DiPaola, R.S.;Beer, T.M.;Eisenberger, M.A. "Adjuvant weekly docetaxel (D) for high-risk prostate cancer patients (pts) after radical prostatectomy (RP): Preliminary data of a multicenter pilot trial." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14_suppl (2004): 4649. [PubMed Link] |
Wojtowicz, M.;Rothermel, J.D.;Anderson, J.;Todd, M.;Rubin, E.H.;DiPaola, R.S. "Phase I dose-escalation trial investigating the safety and tolerability of EPO906 plus estramustine in patients with advanced cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14_suppl (2004): 4623. [PubMed Link] |
Morganstein, N.;Doyle-Lindrud, S.;Goodin, S.;Shih, J.;Altscher, A.;Teller, E.;Zager, R.;Todd, M.;Durivage, H.;DiPaola, R.S. "A phase II salvage trial of transdermal estradiol in the treatment of hormone and chemotherapy refractory prostate cancer: A Cancer Institute of New Jersey Oncology Group Study NJ1803." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14_suppl (2004): 4695. [PubMed Link] |
Strair, R.K.;Schaar, D.;Medina, D.;Todd, M.B.;Aisner, J.;DiPaola, R.S.;Manago, J.;Knox, B.;Jenkinson, A.;Senzon, R.;Baker, C.;Liesel, D.;Ciardella, M.;Kuriyan, M.;Rubin, A.;Lattime, E.C. "Antineoplastic effects of partially HLA-matched irradiated blood mononuclear cells in patients with renal cell carcinoma." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21, 20 (2003): 3785-91. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Durivage, H.J.;Kamen, B.A. "High time for low-dose prospective clinical trials." Cancer 98, 8 (2003): 1559-61. [PubMed Link] | [ Full text ]
Yao, S.L.;DiPaola, R.S. "An evidence-based approach to prostate cancer follow-up." Seminars in oncology 30, 3 (2003): 390-400. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Rubin, E.;Toppmeyer, D.;Eid, J.;Butzbach, D.;Dvorzhinski, D.;Capanna, T.;Cairdella, M.;Shih, J.W.;Goodin, S.;Todd, M.B. "Gemcitabine combined with sequential paclitaxel and carboplatin in patients with urothelial cancers and other advanced malignancies." Medical science monitor : international medical journal of experimental and clinical research 9, 2 (2003): PI5-11. [PubMed Link] | [ Full text ]
Thalasila, A.;Poplin, E.;Shih, J.;Dvorzhinski, D.;Capanna, T.;Doyle-Lindrud, S.;Beers, S.;Goodin, S.;Rubin, E.;DiPaola, R.S. "A phase I trial of weekly paclitaxel, 13- cis-retinoic acid, and interferon alpha in patients with prostate cancer and other advanced malignancies." Cancer chemotherapy and pharmacology 52, 2 (2003): 119-24. [PubMed Link] | [ Full text ]
Marks, L.S.;DiPaola, R.S.;Nelson, P.;Chen, S.;Heber, D.;Belldegrun, A.S.;Lowe, F.C.;Fan, J.;Leaders FE, J.;Pantuck, A.J.;Tyler, V.E. "PC-SPES: herbal formulation for prostate cancer." Urology 60, 3 (2002): 369-75; discussion 376-7. [PubMed Link] | [ Full text ]
DiPaola, R.S. "To arrest or not to G(2)-M Cell-cycle arrest : commentary re: A. K. Tyagi et al., Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G(2)-M arrest, and apoptosis. Clin. cancer res., 8:..." Clinical cancer research : an official journal of the American Association for Cancer Research 8, 11 (2002): 3311-4. [PubMed Link] | [ Full text ]
Morris, M.J.;Tong, W.P.;Cordon-Cardo, C.;Drobnjak, M.;Kelly, W.K.;Slovin, S.F.;Terry, K.L.;Siedlecki, K.;Swanson, P.;Rafi, M.;DiPaola, R.S.;Rosen, N.;Scher, H.I. "Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 8, 3 (2002): 679-83. [PubMed Link] | [ Full text ]
Rafi, M.M.;Vastano, B.C.;Zhu, N.;Ho, C.T.;Ghai, G.;Rosen, R.T.;Gallo, M.A.;DiPaola, R.S. "Novel polyphenol molecule isolated from licorice root (Glycrrhiza glabra) induces apoptosis, G2/M cell cycle arrest, and Bcl-2 phosphorylation in tumor cell lines." Journal of agricultural and food chemistry 50, 4 (2002): 677-84. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Rinehart, J.;Nemunaitis, J.;Ebbinghaus, S.;Rubin, E.;Capanna, T.;Ciardella, M.;Doyle-Lindrud, S.;Goodwin, S.;Fontaine, M.;Adams, N.;Williams, A.;Schwartz, M.;Winchell, G.;Wickersham, K.;Deutsch, P.;Yao, S.L. "Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20, 7 (2002): 1874-9. [PubMed Link] | [ Full text ]
Goodin, S.;Rao, K.V.;DiPaola, R.S. "State-of-the-art treatment of metastatic hormone-refractory prostate cancer." The oncologist 7, 4 (2002): 360-70. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Chenven, E.S.;Shih, W.J.;Lin, Y.;Amenta, P.;Goodin, S.;Shumate, A.;Capanna, T.;Cardiella, M.;Cummings, K.B.;Aisner, J.;Todd, M.B. "Mitoxantrone in patients with prostate specific antigen progression after local therapy for prostate carcinoma." Cancer 92, 8 (2001): 2065-71. [PubMed Link] |
Zhu, N.;Kikuzaki, H.;Sheng, S.;Sang, S.;Rafi, M.M.;Wang, M.;Nakatani, N.;DiPaola, R.S.;Rosen, R.T.;Ho, C.T. "Furanosesquiterpenoids of Commiphora myrrha." Journal of natural products 64, 11 (2001): 1460-2. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Patel, J.;Rafi, M.M. "Targeting apoptosis in prostate cancer." Hematology/oncology clinics of North America 15, 3 (2001): 509-24. [PubMed Link] |
Ankem, M.K.;Hartanto, V.H.;Han, K.R.;Ferlise, V.J.;Bancila, E.;Cummings, K.B.;DiPaola, R.S. "Metastatic renal cell carcinoma presenting as an oral tumor." The Canadian journal of urology 8, 3 (2001): 1295-6. [PubMed Link] |
DiPaola, R.S.;Kumar, P.;Hait, W.N.;Weiss, R.E. "State-of-the-art prostate cancer treatment and research. A report from the Cancer Institute of New Jersey." New Jersey medicine : the journal of the Medical Society of New Jersey 98, 2 (2001): 23-33. [PubMed Link] |
Zhu, N.;Rafi, M.M.;DiPaola, R.S.;Xin, J.;Chin, C.K.;Badmaev, V.;Ghai, G.;Rosen, R.T.;Ho, C.T. "Bioactive constituents from gum guggul (Commiphora wightii)." Phytochemistry 56, 7 (2001): 723-7. [PubMed Link] | [ Full text ]
Cvijic, M.E.;Kita, T.;Shih, W.;DiPaola, R.S.;Chin, K.V. "Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 6, 6 (2000): 2309-17. [PubMed Link] | [ Full text ]
Rafi, M.M.;Rosen, R.T.;Vassil, A.;Ho, C.T.;Zhang, H.;Ghai, G.;Lambert, G.;DiPaola, R.S. "Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid." Anticancer research 20, 4 (2000): 2653-8. [PubMed Link] |
DiPaola, R.S. "Approaches to the treatment of patients with hormone-sensitive prostate cancer." Seminars in oncology 26, 5 Suppl 17 (1999): 24-7. [PubMed Link] |
DiPaola, R.S.;Rafi, M.M.;Vyas, V.;Toppmeyer, D.;Rubin, E.;Patel, J.;Goodin, S.;Medina, M.;Medina, P.;Zamek, R.;Zhang, C.;White, E.;Gupta, E.;Hait, W.N. "Phase I clinical and pharmacologic study of 13-cis-retinoic acid, interferon alfa, and paclitaxel in patients with prostate cancer and other advanced malignancies." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 17, 7 (1999): 2213-8. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Aisner, J. "Overcoming bcl-2- and p53-mediated resistance in prostate cancer." Seminars in oncology 26, 1 Suppl 2 (1999): 112-6. [PubMed Link] |
DiPaola, R.S.;Schuchter, L. "Neurologic protection by amifostine." Seminars in oncology 26, 2 Suppl 7 (1999): 82-8. [PubMed Link] |
DiPaola, R.S.;Zhang, H.;Lambert, G.H.;Meeker, R.;Licitra, E.;Rafi, M.M.;Zhu, B.T.;Spaulding, H.;Goodin, S.;Toledano, M.B.;Hait, W.N.;Gallo, M.A. "Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer." The New England journal of medicine 339, 12 (1998): 785-91. [PubMed Link] | [ Full text ]
Silber, J.H.;Fridman, M.;DiPaola, R.S.;Erder, M.H.;Pauly, M.V.;Fox, K.R. "First-cycle blood counts and subsequent neutropenia, dose reduction, or delay in early-stage breast cancer therapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 16, 7 (1998): 2392-400. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Goodin, S.;Ratzell, M.;Florczyk, M.;Karp, G.;Ravikumar, T.S. "Chemotherapy for metastatic melanoma during pregnancy." Gynecologic oncology 66, 3 (1997): 526-30. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Weiss, R.E.;Cummings, K.B.;Kong, F.M.;Jirtle, R.L.;Anscher, M.;Gallo, J.;Goodin, S.;Thompson, S.;Rasheed, Z.;Aisner, J.;Todd, M.B. "Effect of 13-cis-retinoic acid and alpha-interferon on transforming growth factor beta1 in patients with rising prostate-specific antigen." Clinical cancer research : an official journal of the American Association for Cancer Research 3, 11 (1997): 1999-2004. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Kuczynski, W.I.;Onodera, K.;Ratajczak, M.Z.;Hijiya, N.;Moore, J.;Gewirtz, A.M. "Evidence for a functional kit receptor in melanoma, breast, and lung carcinoma cells." Cancer gene therapy 4, 3 (1997): 176-82. [PubMed Link] |
Salhany, K.E.;Feldman, M.;Kahn, M.J.;Peritt, D.;Schretzenmair, R.D.;Wilson, D.M.;DiPaola, R.S.;Glick, A.D.;Kant, J.A.;Nowell, P.C.;Kamoun, M. "Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation." Human pathology 28, 6 (1997): 674-85. [PubMed Link] |
August, D.A.;DiPaola, R.S.;Kearney, T.;Hait, W. "Model of comprehensive diagnosis and care for breast cancer patients." New Jersey medicine : the journal of the Medical Society of New Jersey 93, 5 (1996): 27-34. [PubMed Link] |
DiPaola, R.S.;Kaufman, A.;Mikhail, M.M. "Treatment of advanced breast cancer: How much chemotherapy is enough?" Seminars in oncology 23, 3 (1996): xv-xxii; discussion xxii-xxiv. [PubMed Link] |
Luger, S.M.;Ratajczak, J.;Ratajczak, M.Z.;Kuczynski, W.I.;DiPaola, R.S.;Ngo, W.;Clevenger, C.V.;Gewirtz, A.M. "A functional analysis of protooncogene Vav's role in adult human hematopoiesis." Blood 87, 4 (1996): 1326-34. [PubMed Link] | [ Full text ]
DiPaola, R.S.;Orel, S.G.;Fowble, B.L. "Ipsilateral breast tumor recurrence following conservative surgery and radiation therapy." Oncology (Williston Park, N.Y.) 8, 12 (1994): 59-68; discussion 71, 75-6. [PubMed Link] |