Samir Softic, MD

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samir.softic@uky.edu

(859) 218-1379

527 C.T. Wethington Bldg, 900 S Limestone St, Lexington, KY 40536-0200

Softic Lab

Position(s):

Assistant Professor of Pediatrics

Affiliation(s):

Pediatrics

Other Affiliation(s):

Pediatrics - Gastroenterology

Pharmacology and Nutritional Sciences - Joint Faculty

Nutritional Sciences Graduate Faculty

Interests / Specialties:

Pediatric fatty liver disease

Bio / Education:

Degree: (2007)
Wright State University, Boonshoft School of Medicine, Dayton, Ohio
Residency: (2012)
Pediatrics, Riley Hospital for Children, Indiana University, Indianapolis
Pediatric Research, Fatty Liver Disease, Cincinnati Children's Hospital Medical Center, Cincinnati
Fellowship: (2015)
Pediatric Gastroenterology, Boston Children’s Hospital, Harvard Medical School, Boston, Mass.
Research Fellow, Obesity & Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Mass.
Certifications and Special Training:
American Board of Pediatrics, Pediatrics
American Board of Pediatrics, Pediatric Gastroenterology

Selected Publications:

https://www.ncbi.nlm.nih.gov/myncbi/1NOehAHnCaBQN/bibliography/public/

PubMed Publications:

Attia, SL ; Softic, S ; Mouzaki, M "Evolving Role for Pharmacotherapy in NAFLD/NASH." Clinical and translational science 14, 1 (2021): 11-19. [PubMed Link] | [ Full text ]
Helsley, RN ; Moreau, F.; Gupta, MK ; Radulescu, A.; DeBosch, B ; Softic, S "Tissue-Specific Fructose Metabolism in Obesity and Diabetes." Current diabetes reports 20, 11 (2020): 64. [PubMed Link] | [ Full text ]
Gupta, MK ; Vethe, H ; Softic, S ; Rao, TN ; Wagh, V ; Shirakawa, J ; Barsnes, H.; Vaudel, M.; Takatani, T ; Kahraman, S ; Sakaguchi, M ; Martinez, R.; Hu, J.; Bjørlykke, Y ; Raeder, H ; Kulkarni, RN "Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells." Stem cell reports 15, 5 (2020): 1067-1079. [PubMed Link] | [ Full text ]
Wang, G.; Yu, Y.; Cai, W.; Batista, TM ; Suk, S ; Noh, HL ; Hirshman, M ; Nigro, P ; Li, ME ; Softic, S ; Goodyear, L ; Kim, JK ; Kahn, CR "Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance." Diabetes 69, 11 (2020): 2294-2309. [PubMed Link] | [ Full text ]
Mooring, M ; Fowl, BH ; Lum, SZC ; Liu, Y.; Yao, K.; Softic, S ; Kirchner, R ; Bernstein, A.; Singhi, AD ; Jay, DG ; Kahn, CR ; Camargo, FD ; Yimlamai, D "Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis." Hepatology (Baltimore, Md.) 71, 5 (2020): 1813-1830. [PubMed Link] | [ Full text ]
Helsley, RN ; Softic, S "Fructose metabolism by the guts cuts liver fat." Journal of molecular medicine (Berlin, Germany) 98, 5 (2020): 733-734. [PubMed Link] |
Saif, M ; Kwanten, WJ ; Carr, JA ; Chen, IX ; Posada, JM ; Srivastava, A.; Zhang, J.; Zheng, Y.; Pinter, M ; Chatterjee, S.; Softic, S ; Kahn, CR ; Leyen, K.; Bruns, OT ; Jain, RK ; Bawendi, MG "Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin." Nature biomedical engineering 4, 12 (2020): 1222. [PubMed Link] | [ Full text ]
Softic, S ; Stanhope, KL ; Boucher, J ; Divanovic, S ; Lanaspa, MA ; Johnson, RJ ; Kahn, CR "Fructose and hepatic insulin resistance." Critical reviews in clinical laboratory sciences 57, 5 (2020): 308-322. [PubMed Link] | [ Full text ]
Saif, M ; Kwanten, WJ ; Carr, JA ; Chen, IX ; Posada, JM ; Srivastava, A.; Zhang, J.; Zheng, Y.; Pinter, M ; Chatterjee, S.; Softic, S ; Kahn, CR ; Leyen, K.; Bruns, OT ; Jain, RK ; Bawendi, MG "Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin." Nature biomedical engineering 4, 8 (2020): 801-813. [PubMed Link] | [ Full text ]
Softic, S ; Meyer, JG ; Wang, GX ; Gupta, MK ; Batista, TM ; Lauritzen, HPMM ; Fujisaka, S ; Serra, D.; Herrero, L ; Willoughby, J ; Fitzgerald, K.; Ilkayeva, O ; Newgard, CB ; Gibson, BW ; Schilling, B ; Cohen, DE ; Kahn, CR "Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins." Cell metabolism 30, 4 (2019): 735-753.e4. [PubMed Link] | [ Full text ]
Wang, G.; Meyer, JG ; Cai, W.; Softic, S ; Li, ME ; Verdin, E.; Newgard, C ; Schilling, B ; Kahn, CR "Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation." Molecular cell 74, 4 (2019): 844-857.e7. [PubMed Link] | [ Full text ]
Li, ME ; Lauritzen, HPMM ; O'Neill, BT ; Wang, CH ; Cai, W.; Brandao, BB ; Sakaguchi, M ; Tao, R.; Hirshman, MF ; Softic, S ; Kahn, CR "Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism." Nature communications 10, 1 (2019): 3412. [PubMed Link] | [ Full text ]
Lekbua, A ; Ouahed, J ; O'Connell, AE ; Kahn, SA ; Goldsmith, JD ; Imamura, T.; Duncan, CN ; , ; Worthey, E ; Snapper, SB ; Softic, S "Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review." Journal of pediatric gastroenterology and nutrition 69, 1 (2019): e13-e18. [PubMed Link] | [ Full text ]
Softic, S ; Kahn, CR "Fatty liver disease: is it nonalcoholic fatty liver disease or obesity-associated fatty liver disease?" European journal of gastroenterology & hepatology 31, 1 (2019): 143. [PubMed Link] | [ Full text ]
Garcia-Castillo, MD ; Chinnapen, DJ ; Welscher, YM Te; Gonzalez, RJ ; Softic, S ; Pacheco, M ; Mrsny, RJ ; Kahn, CR ; von Andrian, UH ; Lau, J.; Pentelute, BL ; Lencer, WI "Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids." eLife 7, (2018): [PubMed Link] | [ Full text ]
Softic, S ; Gupta, MK ; Wang, GX ; Fujisaka, S ; O'Neill, BT ; Rao, TN ; Willoughby, J ; Harbison, C ; Fitzgerald, K.; Ilkayeva, O ; Newgard, CB ; Cohen, DE ; Kahn, CR "Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling." The Journal of clinical investigation 128, 3 (2018): 1199. [PubMed Link] | [ Full text ]
Rao, TN ; Gupta, MK ; Softic, S ; Wang, LD ; Jang, YC ; Thomou, T ; Bezy, O ; Kulkarni, RN ; Kahn, CR ; Wagers, AJ "Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors." The EMBO journal 37, 24 (2018): [PubMed Link] | [ Full text ]
Meyer, JG ; Softic, S ; Basisty, N ; Rardin, MJ ; Verdin, E.; Gibson, BW ; Ilkayeva, O ; Newgard, CB ; Kahn, CR ; Schilling, B "Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose." PloS one 13, 12 (2018): e0208973. [PubMed Link] | [ Full text ]
Giles, DA ; Moreno-Fernandez, ME ; Stankiewicz, TE ; Graspeuntner, S ; Cappelletti, M ; Wu, D.; Mukherjee, R ; Chan, CC ; Lawson, MJ ; Klarquist, J ; Sünderhauf, A ; Softic, S ; Kahn, CR ; Stemmer, K ; Iwakura, Y.; Aronow, BJ ; Karns, R ; Steinbrecher, KA ; Karp, CL ; Sheridan, R ; Shanmukhappa, SK ; Reynaud, D ; Haslam, DB ; Sina, C ; Rupp, J ; Hogan, SP ; Divanovic, S "Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling." Nature medicine 23, 10 (2017): 1241. [PubMed Link] | [ Full text ]
Softic, S ; Gupta, MK ; Wang, GX ; Fujisaka, S ; O'Neill, BT ; Rao, TN ; Willoughby, J ; Harbison, C ; Fitzgerald, K.; Ilkayeva, O ; Newgard, CB ; Cohen, DE ; Kahn, CR "Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling." The Journal of clinical investigation 127, 11 (2017): 4059-4074. [PubMed Link] | [ Full text ]
Bhattacharjee, J ; Kirby, M.; Softic, S ; Miles, L ; Salazar-Gonzalez, RM ; Shivakumar, P ; Kohli, R "Hepatic Natural Killer T-cell and CD8+ T-cell Signatures in Mice with Nonalcoholic Steatohepatitis." Hepatology communications 1, 4 (2017): 299-310. [PubMed Link] | [ Full text ]
Giles, DA ; Moreno-Fernandez, ME ; Stankiewicz, TE ; Graspeuntner, S ; Cappelletti, M ; Wu, D.; Mukherjee, R ; Chan, CC ; Lawson, MJ ; Klarquist, J ; Sünderhauf, A ; Softic, S ; Kahn, CR ; Stemmer, K ; Iwakura, Y.; Aronow, BJ ; Karns, R ; Steinbrecher, KA ; Karp, CL ; Sheridan, R ; Shanmukhappa, SK ; Reynaud, D ; Haslam, DB ; Sina, C ; Rupp, J ; Hogan, SP ; Divanovic, S "Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling." Nature medicine 23, 7 (2017): 829-838. [PubMed Link] | [ Full text ]
O'Neill, BT ; Lee, KY ; Klaus, K ; Softic, S ; Krumpoch, MT ; Fentz, J ; Stanford, KI ; Robinson, MM ; Cai, W.; Kleinridders, A ; Pereira, RO ; Hirshman, MF ; Abel, ED ; Accili, D.; Goodyear, LJ ; Nair, KS ; Kahn, CR "Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis." The Journal of clinical investigation 126, 9 (2016): 3433-46. [PubMed Link] | [ Full text ]
Softic, S ; Cohen, DE ; Kahn, CR "Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease." Digestive diseases and sciences 61, 5 (2016): 1282-93. [PubMed Link] | [ Full text ]
Fujisaka, S ; Ussar, S ; Clish, C ; Devkota, S ; Dreyfuss, JM ; Sakaguchi, M ; Soto, M.; Konishi, M ; Softic, S ; Altindis, E ; Li, N.; Gerber, G.; Bry, L ; Kahn, CR "Antibiotic effects on gut microbiota and metabolism are host dependent." The Journal of clinical investigation 126, 12 (2016): 4430-4443. [PubMed Link] | [ Full text ]
Boucher, J ; Softic, S ; Ouaamari, El ; Krumpoch, MT ; Kleinridders, A ; Kulkarni, RN ; O'Neill, BT ; Kahn, CR "Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function." Diabetes 65, 8 (2016): 2201-13. [PubMed Link] | [ Full text ]
Softic, S ; Boucher, J ; Solheim, MH ; Fujisaka, S ; Haering, MF ; Homan, EP ; Winnay, J ; Perez-Atayde, AR ; Kahn, CR "Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD." Diabetes 65, 8 (2016): 2187-200. [PubMed Link] | [ Full text ]
Ussar, S ; Griffin, NW ; Bezy, O ; Fujisaka, S ; Vienberg, S ; Softic, S ; Deng, L.; Bry, L ; Gordon, JI ; Kahn, CR "Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome." Cell metabolism 22, 3 (2015): 516-530. [PubMed Link] |
Harley, IT ; Stankiewicz, TE ; Giles, DA ; Softic, S ; Flick, LM ; Cappelletti, M ; Sheridan, R ; Xanthakos, SA ; Steinbrecher, KA ; Sartor, RB ; Kohli, R ; Karp, CL ; Divanovic, S "IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice." Hepatology (Baltimore, Md.) 59, 5 (2014): 1830-9. [PubMed Link] | [ Full text ]
Foster, MT ; Softic, S ; Caldwell, J.; Kohli, R ; de Kloet, AD ; Seeley, RJ "Subcutaneous Adipose Tissue Transplantation in Diet-Induced Obese Mice Attenuates Metabolic Dysregulation While Removal Exacerbates It." Physiological reports 1, 2 (2013): [PubMed Link] | [ Full text ]
Softic, S ; Kirby, M.; Berger, NG ; Shroyer, NF ; Woods, SC ; Kohli, R "Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins." PloS one 7, 6 (2012): e38952. [PubMed Link] | [ Full text ]
Foster, MT ; Shi, H.; Softic, S ; Kohli, R ; Seeley, RJ ; Woods, SC "Transplantation of non-visceral fat to the visceral cavity improves glucose tolerance in mice: investigation of hepatic lipids and insulin sensitivity." Diabetologia 54, 11 (2011): 2890-9. [PubMed Link] | [ Full text ]
Kohli, R ; Kirby, M.; Xanthakos, SA ; Softic, S ; Feldstein, AE ; Saxena, V ; Tang, PH ; Miles, L ; Miles, MV ; Balistreri, WF ; Woods, SC ; Seeley, RJ "High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 52, 3 (2010): 934-44. [PubMed Link] | [ Full text ]
Karp, CL ; Flick, LM ; Park, KW ; Softic, S ; Greer, TM ; Keledjian, R.; Yang, R.; Uddin, J ; Guggino, WB ; Atabani, SF ; Belkaid, Y ; Xu, Y.; Whitsett, JA ; Accurso, FJ ; Wills-Karp, M.; Petasis, NA "Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway." Nature immunology 5, 4 (2004): 388-92. [PubMed Link] | [ Full text ]
Softic, S " A single dispatch center and communication system ." Medicinski arhiv 54, 4 (2000): 227-9. [PubMed Link] |

Lab Website

https://softiclab.ukhc.org/